Binding of Tetracyclines and Other Antibiotics to Ribosomes
Tetracyclines inhibit ribosomal functions. From the observed interference of the antibiotics with initiation and elongation steps in cell-free systems of peptide synthesis, it was concluded that tetracyclines block the A-site of the 30S ribosomal subunit (see Pestka, 1971, for summarizing references).
KeywordsRibosomal Subunit Fluorescence Enhancement tRNA Species Tetracycline Derivative Ribosomal Particle
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