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Binding of Tetracyclines and Other Antibiotics to Ribosomes

  • H. Kersten
Conference paper
Part of the Topics in Infectious Diseases book series (TIDIS, volume 1)

Abstract

Tetracyclines inhibit ribosomal functions. From the observed interference of the antibiotics with initiation and elongation steps in cell-free systems of peptide synthesis, it was concluded that tetracyclines block the A-site of the 30S ribosomal subunit (see Pestka, 1971, for summarizing references).

Keywords

Ribosomal Subunit Fluorescence Enhancement tRNA Species Tetracycline Derivative Ribosomal Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. FEY, G., M. REISS, and H. KERSTEN: Interaction of tetracyclines with ribosomal subunits from Escherichia coli. A fluorometric investigation. Biochemistry 12, 1160–1164 (1973).PubMedCrossRefGoogle Scholar
  2. HASELTINE, W.A., and R BLOCK: Synthesis of guanosine tetra-and pentaphosphate requires the presence of a codon-specific, uncharged transfer ribonucleic acid in the acceptor site of ribosomes. Proc. Nat. Acad. Sci. USA 70, 1564–1568 (1973)PubMedCrossRefGoogle Scholar
  3. KERSTEN, H.: Changes in the properties of ribosomes and transfer RNA induced by inhibitors of protein synthesis. In: Progress in Molecular and Subcellular Biology, Vol. 2, (Hahn, F.E., ed.) pp. 58–68, Berlin-Heidelberg-New York: Springer 1971.Google Scholar
  4. LUND, E., and N.O. KJELDGAARD: Metabolism of guanosine tetraphosphate in Escherichia coli. Eur. J. Biochem. 28, 316–326 (1972).PubMedCrossRefGoogle Scholar
  5. MANN, M.B., and P.C. HUANG: Behavior of chloramphenicol-induced phenylalanine transfer ribonucleic acid during recovery from chloramphenicol treatment in Escherichia coli. Biochemistry 12, 5289–5294 (1973).PubMedCrossRefGoogle Scholar
  6. PESTKA, S.: Inhibitions of ribosome functions. Ann. Rev.Microbiol. 25, 487–562 (1971).CrossRefGoogle Scholar
  7. SCHELLBERGER, H., and H. KERSTEN: Arginine dependent occurrence of a new isoaccepting tRNA Phe in E. coli. Abstr. FEBS Meeting, Budapest 1974.Google Scholar
  8. WATERS, L.C., L. SHUGART, W.-K. YANG, and A.N. BEST: Some physical and biological properties of 4-thiouridine-and dihydro-uridinedeficient tRNA from chloramphenicol-treated Escherichia coli. Arch. Biochem. Biophys. 156, 780–793 (1973).Google Scholar
  9. WHITE, J.P., and C.R. CANTOR: Role of magnesium in the binding of tetracycline to Escherichia coli ribosomes. J. Mol. Biol. 58, 397–400 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1975

Authors and Affiliations

  • H. Kersten

There are no affiliations available

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