Binding of Tetracyclines and Other Antibiotics to Ribosomes

  • H. Kersten
Conference paper
Part of the Topics in Infectious Diseases book series (TIDIS, volume 1)


Tetracyclines inhibit ribosomal functions. From the observed interference of the antibiotics with initiation and elongation steps in cell-free systems of peptide synthesis, it was concluded that tetracyclines block the A-site of the 30S ribosomal subunit (see Pestka, 1971, for summarizing references).


Ribosomal Subunit Fluorescence Enhancement tRNA Species Tetracycline Derivative Ribosomal Particle 
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© Springer-Verlag/Wien 1975

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  • H. Kersten

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