Altered Methylation of Ribosomal RNA in Erythromycin-Resistant Staphylococcus Aureus

  • Bernard Weisblum
Conference paper
Part of the Topics in Infectious Diseases book series (TIDIS, volume 1)


Methylation of 23S ribosomal RNA, a structural component of the 50S ribosome subunit, the receptor for macrolide and lincosamide and streptogramin-B type (“MLS”) antibiotics has been identified as the chemical change responsible for resistance to these antibiotics in clinical isolates of Staphylococcus aureus and Streptococcus pyogenes. In this work, I would like to review microbiological, biochemical, and genetic studies of resistance to these antibiotics. This review is organized under four main headings:
  1. (A)

    Conclusions regarding rRNA methylation and erythromycin resistance.

  2. (B)

    A summary of works of previous investigators interpreted in terms of the methylation reaction.

  3. (C)

    A summary of work on which the conclusions regarding rRNA methylation are based.

  4. (D)

    Epidemiological and clinical implications of these studies.



Resistant Cell Macrolide Antibiotic Erythromycin Resistance Altered Methylation Adenine Methylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used are


macrolide and lincosamide and streptogramin-B type antibiotics.


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© Springer-Verlag/Wien 1975

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  • Bernard Weisblum

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