Changes and Present Status of Resistance to Antimicrobial Drugs in Gram-Negative Bacteria
Apart from its natural (non-acquired) resistance the actual antibiotic sensitivity pattern of a pathogenic species of bacteria results from several different factors. These factors comprise not only features of the antimicrobial agent like chemical structure or mode of action or the special abilities of an individual microorganism. They also include method of application and dosage of the antibiotic substance, composition of case material, and epidemiologic and hygienic peculiarities. Therefore antibiotic sensitivity patterns are primarily of strictly local character and cannot be generalized without further considerations. Even when an evaluation of sensitivity patterns has been performed in an area, it is not easy to deduce changes in sensitivity or therapeutic plans from a single investigation because the situation can deteriorate very quickly by changes of the usual therapeutic schemes, by regrouping of the local spectrum of pathogens, or by acquisition of resistance factors. This is especially true for many of the gram-negative bacteria which are well-known as microbes with a high potential for increasing resistance to antibiotics. In order to obtain results of common interest in spite of the above-mentioned considerations, we tried to delineate basic types of changes in bacterial sensitivity in the region of Cologne with which the current antibiotic sensitivity patterns can be correlated.
KeywordsPseudomonas Aeruginosa Serratia Marcescens Antimicrobial Drug Sensitive Strain Average Sensitivity
Unable to display preview. Download preview PDF.