Abstract
Some of the manifold biological activities of endotoxins of gram-negative bacteria would be very interesting for therapeutic use in human patients. The following are the phenomena which have already been extensively studied in animal experiments:
-
1.
Considerable protection against severe and eventually lethal side-effects of radiotherapy or chemotherapeutic agents by the stimulation of granulopoiesis.
-
2.
The necrotizing effect of endotoxins on malignant tumors.
-
3.
The pyrogenic effect of endotoxins.
-
4.
The development of tolerance during repeated treatment with endotoxins.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Atkins, E.: Pathogenesis of fever. Physiol. Rev. 40: 580 (1960).
Beeson, P. B.: J. clin. Invest. 27: 524 (1948).
Fritsch, H., Krecke, H. -J., Becker, B., Urbaschek, B., Nowotny, A.: Verh. dtsch. Ges. inn. Med. 74: 1151 (1968).
Havas, H. F., Donelly, A. J., Levim, S.I.: Cancer Res. 20: 393 (1960).
Nowotny, A.: Nature (London) 197: 721 (1963).
Nowotny, A., Golub, S., Key, B.: Proc. Soc. exp. Biol. Med. 136: 66 (1971).
Ostlund, R. E., Biskop, C. R., Athens, J. W.: Proc. Soc. exp. Biol. Med. 137: 763 (1971).
Perrault, A., Shear, M. J.: Cancer Res. 9: 626 (1949).
Ringert, R.H.: Untersuchungen zum Wirkungsmechanismus des Strahlenschutzes eines detoxifizierten Endotoxins. Inaug. Dis s. Universität Heidelberg (1971).
Urbaschek, B., Nowotny, A.: Endotoxin tolerance induced by endotoxoid. In:Chedid, M. L.: La structure et les effets biologiques des produits bactériens provenant de germes gram-négatifs, p. 357 (Editions du Centre National de la Recherche Scientifique 1969 ).
Urbaschek, B., Urbaschek, R., Mauff, G., Gerrlach, Ch., Huth, K., Jung, F., Ringert, R. H., Nowotny, A., Fritsch, H.: Experientia 27: 803 (1971).
Urbaschek, B.: Zur Frage des Wirkungsmechanismus bakterieller Endotoxine und seiner Beeinflussung. Habilitationsschrift Universität Heidelberg (1967).
Urbaschek, B., Ringert, R.H.: Influence of a detoxified endotoxin on the bone marrow. In this volume.
Wolff, Sh. M., Rubenstein, M., Mulholland, J. H., Alling, D. W.: Blood 26: 190 (1965).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag/Wien
About this chapter
Cite this chapter
Huth, E.F. (1975). Clinical Use of Endotoxoid. In: Urbaschek, B., Urbaschek, R., Neter, E. (eds) Gram-Negative Bacterial Infections and Mode of Endotoxin Actions. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8396-0_57
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8396-0_57
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8398-4
Online ISBN: 978-3-7091-8396-0
eBook Packages: Springer Book Archive