Some of the manifold biological activities of endotoxins of gram-negative bacteria would be very interesting for therapeutic use in human patients. The following are the phenomena which have already been extensively studied in animal experiments:
  1. 1.

    Considerable protection against severe and eventually lethal side-effects of radiotherapy or chemotherapeutic agents by the stimulation of granulopoiesis.

  2. 2.

    The necrotizing effect of endotoxins on malignant tumors.

  3. 3.

    The pyrogenic effect of endotoxins.

  4. 4.

    The development of tolerance during repeated treatment with endotoxins.



Osteogenic Sarcoma Chemotherapeutic Agent Solid Malignant Tumor Endotoxin Tolerance Bone Marrow Depression 
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  1. 1.
    Atkins, E.: Pathogenesis of fever. Physiol. Rev. 40: 580 (1960).Google Scholar
  2. 2.
    Beeson, P. B.: J. clin. Invest. 27: 524 (1948).PubMedGoogle Scholar
  3. 3.
    Fritsch, H., Krecke, H. -J., Becker, B., Urbaschek, B., Nowotny, A.: Verh. dtsch. Ges. inn. Med. 74: 1151 (1968).Google Scholar
  4. 4.
    Havas, H. F., Donelly, A. J., Levim, S.I.: Cancer Res. 20: 393 (1960).PubMedGoogle Scholar
  5. 5.
    Nowotny, A.: Nature (London) 197: 721 (1963).CrossRefGoogle Scholar
  6. 6.
    Nowotny, A., Golub, S., Key, B.: Proc. Soc. exp. Biol. Med. 136: 66 (1971).Google Scholar
  7. 7.
    Ostlund, R. E., Biskop, C. R., Athens, J. W.: Proc. Soc. exp. Biol. Med. 137: 763 (1971).Google Scholar
  8. 8.
    Perrault, A., Shear, M. J.: Cancer Res. 9: 626 (1949).Google Scholar
  9. 9.
    Ringert, R.H.: Untersuchungen zum Wirkungsmechanismus des Strahlenschutzes eines detoxifizierten Endotoxins. Inaug. Dis s. Universität Heidelberg (1971).Google Scholar
  10. 10.
    Urbaschek, B., Nowotny, A.: Endotoxin tolerance induced by endotoxoid. In:Chedid, M. L.: La structure et les effets biologiques des produits bactériens provenant de germes gram-négatifs, p. 357 (Editions du Centre National de la Recherche Scientifique 1969 ).Google Scholar
  11. 11.
    Urbaschek, B., Urbaschek, R., Mauff, G., Gerrlach, Ch., Huth, K., Jung, F., Ringert, R. H., Nowotny, A., Fritsch, H.: Experientia 27: 803 (1971).PubMedCrossRefGoogle Scholar
  12. 12.
    Urbaschek, B.: Zur Frage des Wirkungsmechanismus bakterieller Endotoxine und seiner Beeinflussung. Habilitationsschrift Universität Heidelberg (1967).Google Scholar
  13. 13.
    Urbaschek, B., Ringert, R.H.: Influence of a detoxified endotoxin on the bone marrow. In this volume.Google Scholar
  14. 14.
    Wolff, Sh. M., Rubenstein, M., Mulholland, J. H., Alling, D. W.: Blood 26: 190 (1965).PubMedGoogle Scholar

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© Springer-Verlag/Wien 1975

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  • E. F. Huth

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