On the Escape of Endotoxin from the Intestine
We became interested in endotoxin as a result of our work on liver failure. We noted during experimentally induced acute hepatic insufficiency in the dog a number of changes (1, 2) which could be attributed to the development of gram-negative sepsis of enteric origin (3). Subsequent reports, notably those by Bjørneboe (4) and by Triger (5), indicate that in patients with liver cirrhosis E. coli antibody titers are markedly increased. This suggests that during hepatic insufficiency in man enteric organisms or their products are also able to escape from the intestine (6).
KeywordsPortal Vein Thoracic Duct Lead Acetate Hepatic Insufficiency Hypertonic Solution
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