High Molecular Weight Derivatives of Fibrinogen and their Relation to the Total Fibrinogen Content Following the Infusion of Endotoxin in Pregnant Rabbits

  • R. von Hugo
  • H. Graeff
  • G. Müller-Berghaus


High molecular weight derivatives of fibrinogen can be demonstrated in human cases of disseminated intravascular coagulation (DIC) (1, 2) in concentrations of up to 15 % of the total fibrinogen content (3). At least some of these derivatives could also be shown in uncomplicated human pregnancy (4) but the concentrations observed amounted only to 2–3% of the total fibrinogen content. No high molecular weight derivatives could be demonstrated with the methods applied in plasma of healthy male blood donors.


Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Elution Pattern Fibrinogen Content Fibrinogen Degradation Product 
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Copyright information

© Springer-Verlag/Wien 1975

Authors and Affiliations

  • R. von Hugo
  • H. Graeff
  • G. Müller-Berghaus

There are no affiliations available

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