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Gram-Negative Bacterial Infections and Mode of Endotoxin Actions pp 362–366Cite as

Trigger Mechanism of Endotoxin-Induced Intravascular Coagulation

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Abstract

According to the classical theory of blood coagulation, the in vitro activation of coagulation in the intrinsic pathway starts with the activation of factor XII (Hageman factor) and in the extrinsic pathway with release of tissue thromboplastin. In both pathways, platelets with their surface and their constituents play an important role as accelerators of coagulation activation. In this short review, I would like to concentrate on the significance of Hageman factor activation (intrinsic pathway), of tissue thromboplastin from leukocytes and/or endothelial cells (extrinsic pathway) and of platelets (extrinsic and intrinsic systems).

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Authors
  1. G. Müller-Berghaus
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Editors and Affiliations

  1. Abteilung für Immunologie und Serologie am Institut für Hygiene und Medizinische Mikrobiologie der Fakultät für Klinische Medizin Mannheim, Universität Heidelberg, Mannheim, Federal Republic of Germany

    Bernhard Urbaschek  & Renate Urbaschek  & 

  2. Departments of Microbiology and Pediatrics, State University of New York at Buffalo, Buffalo, N.Y., USA

    Erwin Neter M. D.

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© 1975 Springer-Verlag/Wien

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Müller-Berghaus, G. (1975). Trigger Mechanism of Endotoxin-Induced Intravascular Coagulation. In: Urbaschek, B., Urbaschek, R., Neter, E. (eds) Gram-Negative Bacterial Infections and Mode of Endotoxin Actions. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8396-0_47

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  • DOI: https://doi.org/10.1007/978-3-7091-8396-0_47

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-8398-4

  • Online ISBN: 978-3-7091-8396-0

  • eBook Packages: Springer Book Archive

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