Influence of Lipid A and Various LPS-Preparations on the Third Component of Complement (C 3): Biological Significance of this Interaction
Endotoxic lipopolysaccharides (LPS) are known to interact with the complement system. This interaction, leading to the activation of C3, takes place in normal as well as in C4-deficient guinea pig serum and thus represents an example for the alternate pathway of C activation starting with C3. This does not exclude the activation of Cl, C4 and C2 provided a LPS-specific antibody is available.
KeywordsComplement System Cobra Venom Endotoxin Action Maximal Plateau Cobra Venom Factor
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