Initial Liberation of Biogenic Amines and Effect of Further Mediators Following Application of Endotoxins

  • A. Schauer


In shock sensitive species shock symptoms develop very quickly after the application of endotoxins. This phenomenon has led to extensive comparisons of anaphylactic and endotoxin shocks (4). The anaphylactic shock clearly results from a massive liberation of histamine from tissue mast cells. According to Becker and Austen (3) this takes place under the influence of so-called homocytotropic antibodies after sensibilization of the mast cells, as shown in experiments with rats. In contrast to this relatively simple mechanism, the factors leading to endotoxin shock are many-faceted and much more complex.


Mast Cell Biogenic Amine Anaphylactic Shock Histamine Level Kinin Level 
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© Springer-Verlag/Wien 1975

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  • A. Schauer

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