Abstract
An outsider like myself is not able to give any news to the specialists attending this meeting but only to present you with my impressions from studying the literature. However, according to the conception of Dr. Urbaschek, representatives of pharmacology and pathology are to be involved in the discussion on endotoxemia and on pathophysiology of gram-negative infections. As a pharmacologist I am interested especially in the pharmacology of the mediators of endotoxin shock. There is no doubt that in shock some highly effective substances, for instance histamine, bradykinin or catecholamines, are released from stores or freshly produced from precursors as in the case of anaphylactic shock. Furthermore, certain chain reactions are activated of which only the complement activation should be considered.
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References
Bhagat, B., Cavanagh, D., Merrild, B. N., Rana, M. W., Rao, P. S.: Brit. J. Pharmacol. 39: 688 (1970).
Bitensky, M. W., Gorman, R. E., Thomas, L.: Proc. 138: 773 (1971).
Brobmann, G. F., Ulano, H. B., Hinshaw, L. B., Jacobson, E. D.: Amer. J. Physiol. 219: 1464 (1970).
Brown, D. L., Lachmann, P. J.: Int. Arch. Allergy 45: 193 (1973).
Carretero, O.A., Nasjletti, A., Fasciolo, J. C.: Experientia 26: 63 (1970).
Erdös, E.G., Miwa, I.: Fed. Proc. 27: 92 (1968).
Giertz, H.: Bildung und Freisetzung biologisch aktiver Substanzen unter besonderer Berücksichtigung des Histamins. In: Filipp, G.: Pathogenese und Therapie allergischer Reaktionen, p. 424 ( Ferdinand Enke Verlag, Stuttgart 1966 ).
Hall, R. C., Hodge, R. L.: J. Physiol. 213: 69 (1971).
Hinshaw, L. B.: Release of vasoactive agents and the vascular effects of endotoxin. In: Kadis, S., Weinbaum, G., Ajl, S. J.: Microbial toxins, Vol. 5, p. 209 ( Academic Press, New York and London 1971 ).
Hinshaw, L. B., Emerson, T. E., lampietro, P. F., Brake, C. M.: Amer. J. Physiol. 203: 600 (1972).
Hinshaw, L. B., Vick, J. A., Carlson, C. H., Fan, Y. -L.: Proc. Soc. exp. Biol. Med. 104: 379 (1960).
Johnson, K. J., Ward, P.A.: J. Immunol. 106: 1125 (1971).
Kane, M. A., May, J. E., Frank, M. M.: J. clin. Invest. 52: 370 (1973).
Kessler, E., Hughes, R. C., Bennett, E. N., Nadela, S. M.: J. Lab. clin. Med. 81: 85 (1973).
Krawczak, J. J., Brodie, B. B.: Pharmacology 3: 65 (1970).
Mergenhagen, S. E., Snyderman, R., Gewurz, H., Shin, H. S.: Curr. Topics Microbiol. Immunol. 50: 37 (1969).
Philips, J. K., Snyderman, R., Mergenhagen, S. E.: J. Immunol. 109: 334 (1972).
Pohorecky, L.A., Wurtman, R. J., Taam, D., Fine, J.: Proc. Soc. exp. Biol. Med. 140: 739 (1972).
Rao, P.S., Bhagat, B.D., Cavanagh, D.: Proc. Soc. exp. Biol. Med. 141: 412 (1972).
Schayer, R. W.: Amer. J. Physiol. 198: 1187 (1960).
Spink, W. W., Reddin, J., Zak, S. J., Peterson, M., Starzecki, B., Seljeskog, E.: J. clin. Invest. 45: 78 (1966).
Urbaschek, B.: Addendum - The effects of endotoxins in the microcirculation. In: Kadis, S., Weinbaum, G., Ajl, S. J.: Microbial toxins, Vol. 5, p. 261 ( Academic Press, New York and London 1971 ).
Vick, J. A., Mehlman, B., Heiffer, M.H.: Proc. Soc. exp. Biol. Med. 137: 902 (1971).
Weil, M. H., Spink, W. W.: J. Lab, clin. Med. 50: 501 (1957).
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Giertz, H. (1975). Pharmacological Aspects of Endotoxin Effects. In: Urbaschek, B., Urbaschek, R., Neter, E. (eds) Gram-Negative Bacterial Infections and Mode of Endotoxin Actions. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8396-0_39
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DOI: https://doi.org/10.1007/978-3-7091-8396-0_39
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