Carbohydrate Metabolism during Experimental Endotoxemia
For many years experimental mouse typhoid has served as a model for studying host metabolism during progressive infectious bacterial disease (2). Although the intracellular parasitism of Salmonella typhimurium has been studied with this system, by far, the most work has been concerned with the exact role of endotoxin in pathogenesis of gram-negative sepsis. One of the first metabolic alterations noted to occur in experimentally infected animals as well as those given an injection of endotoxin was the rapid depletion of total body carbohydrate (2). This particular response to endotoxin has been observed by many investigators, yet its exact cause(s) remains to be elucidated.
KeywordsGlycogen Synthesis Glycogen Metabolism Phosphatase Reaction Carbohydrate Loss Liver Glycogen Phosphorylase
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