Carbohydrate Metabolism during Experimental Endotoxemia

  • R. E. McCallum


For many years experimental mouse typhoid has served as a model for studying host metabolism during progressive infectious bacterial disease (2). Although the intracellular parasitism of Salmonella typhimurium has been studied with this system, by far, the most work has been concerned with the exact role of endotoxin in pathogenesis of gram-negative sepsis. One of the first metabolic alterations noted to occur in experimentally infected animals as well as those given an injection of endotoxin was the rapid depletion of total body carbohydrate (2). This particular response to endotoxin has been observed by many investigators, yet its exact cause(s) remains to be elucidated.


Glycogen Synthesis Glycogen Metabolism Phosphatase Reaction Carbohydrate Loss Liver Glycogen Phosphorylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Berry, L. J., Rippe, D. F.: J. infect. Dis., Suppl. 128: S 118 (1973).CrossRefGoogle Scholar
  2. 2.
    Berry, L. J., Smythe, D. S.: Ann. N. Y. Acad. Sci. 88: 1278 (1960).CrossRefGoogle Scholar
  3. 3.
    Bitensky, M. W., Gorman, R. E., Thomas, L.: Proc. Soc. exp. Biol. Med. 138: 773 (1971).PubMedGoogle Scholar
  4. 4.
    De Wulf, H., Hers, H. G.: Eur. J. Biochem. 6: 552 (1968).PubMedCrossRefGoogle Scholar
  5. 5.
    Hamosh, M., Shapiro, B.: Brit. J. exp. Path. 41: 372 (1960).Google Scholar
  6. 6.
    Hickenbottom, R. S., Hornbrook, K. R.: J. Pharmacol. exp. Ther. 178: 383 (1971).PubMedGoogle Scholar
  7. 7.
    Lewis, A. E.: Biostatistics. ( Reinhold Publishing Corp., New York 1966 ).Google Scholar
  8. 8.
    McCallum, R. E., Berry, L. J.: Infect. Immunity 7: 642 (1973).Google Scholar
  9. 9.
    Reed, L. J., Muench, H. A.: Amer. J. Hyg. 27: 493 (1938).Google Scholar
  10. 10.
    Segal, H. L.: Science 180: 25 (1973).CrossRefGoogle Scholar
  11. 11.
    Stalmans, W., De Wulf, H., Hers, H. G.: Eur. J. Biochem. 18: 582 (1971).PubMedCrossRefGoogle Scholar
  12. 12.
    Thomas, J. A., Schlender, K. K., Lamer, J.: Anal. Biochem. 25: 486 (1968).CrossRefGoogle Scholar
  13. 13.
    Wilcoxon, F., Wilcox, R. A.: Some rapid approximate statistical procedures. ( American Cyanimide Co., New York 1949 ).Google Scholar
  14. 14.
    Zwadyk, P. Jr., Snyder, I. S.: Proc. Soc. exp. Biol. Med. 142: 299 (1973).PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1975

Authors and Affiliations

  • R. E. McCallum

There are no affiliations available

Personalised recommendations