Effect of Endotoxin on Metabolism and the Metabolic Changes in Bacterial Shock

  • L. J. Berry
  • M. W. Laney
  • R. N. Moore


At the Airlie House conference in May 1972, I reported (2) that endotoxin inhibits the synthesis of phosphoenolpyruvate carboxykinase (PEPCK). This enzyme more than doubles in activity and in amount following an injection of hydrocortisone or the stress of fasting. The increase in amount of enzyme is blocked by either endotoxin or actinomycin D as demonstrated by radial immunodiffusion (12). More recently, Rippe and Berry (13) have found a similar effect of endotoxin on a second inducible hepatic enzyme, trytophan oxygenase (TO). Because isotopically labeled endotoxin has not been found to localize in liver parenchymal cells which contain the inducible enzymes (3, 10), it has been assumed that the observed inhibition of enzyme synthesis is mediated rather than the result of direct action.


Sodium Chloride Solution Liver Glycogen Phosphoenolpyruvate Carboxykinase Liver Parenchymal Cell Radial Immunodiffusion 
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  1. 1.
    Beeson, P. B.: J. exp. Med. 86: 39 (1947).PubMedCrossRefGoogle Scholar
  2. 2.
    Berry, L. J., Rippe, D. F.: J. infect. Dis. 128: S118 (1973).CrossRefGoogle Scholar
  3. 3.
    Braude, A. I., Carey, F. J., Zalesky, M.: J. clin. Invest. 34: 858 (1955).PubMedCrossRefGoogle Scholar
  4. 4.
    Fox, A. E., Gawlik, D. L., Ballantyne, D. L., Jr., Freedman, H. H.: Influence of oxisuran, a differential inhibitor of cell-mediated hypersensitivity, an allograft survival and humoral immunity. Unpublished.Google Scholar
  5. 5.
    Freedman, H. H.: J. exp, Med. 111: 453 (1960).CrossRefGoogle Scholar
  6. 6.
    Freedman, H. H., Fox, A. E., Shavel, J., Jr., Morrison, G. C.: Proc. Soc. exp. Biol. Med. 139: 909 (1972).Google Scholar
  7. 7.
    Kemp, A., Kits van Heijningen, A. J. M.: Biochem. J. 56: 646 (1954).PubMedGoogle Scholar
  8. 8.
    Knox, W. E., Auerbach, V.H.: J. biol. Chem. 214: 307 (1955).PubMedGoogle Scholar
  9. 9.
    Nowotny, A.: Basis Exercises in Immunochemistry, p. 26 ( Springer, New York 1969 ).Google Scholar
  10. 10.
    Noyes, H. E., Mclnturf, C. R., Blahuta, G. J.: Proc. Soc. exp. Biol. Med. 100: 65 (1959).Google Scholar
  11. 11.
    Phillips, L. J., Berry, L. J.: Amer. J. Physiol. 218: 1140 (1970).Google Scholar
  12. 12.
    Rippe, D. F., Berry, L. J.: Infect. Immunity 6: 766 (1972).Google Scholar
  13. 13.
    Rippe, D. F., Berry, L. J.: Immunological quantitation of hepatic tryptophan oxygenase in endotoxin-poisoned mice. Infect. Immunity. In press 1973.Google Scholar
  14. 14.
    Stockman, G. D., Heim, L. R., South, M. A., Trentin, J. J.: J. Immunol. 110: 277 (1973).PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1975

Authors and Affiliations

  • L. J. Berry
  • M. W. Laney
  • R. N. Moore

There are no affiliations available

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