Endotoxin-Induced Tumor Resistance
That bacterial infection leads to tumor regression was first reported by Busch(3). The same observation was made by Coley (5), who artificially infected patients with live Stretococci in order to make their tumors undergo necrosis. A tumor necrotizing preparation was isolated from Serratia marcescens by Shear (17) and from E. coli by Ikawa et al. (8). Very recently, infections with live BCG bacteria were used for combined immuno- and chemotherapy of leukemia by Mathe et al. (11).
KeywordsSpleen Cell Adoptive Transfer Serratia Marcescens Tumor Resistance Peritoneal Exudate Cell
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- 2.Anderson, J., Sjöberg, O., Möller, G.: Transpl. Rev. 11: 131 (1972).Google Scholar
- 3.Busch: Berl. Klin. Wschr. 3: 245 (1866).Google Scholar
- 11.Maths, G., Amiel, J. -L., Schwarzenberg, L., Schneider, M.: J. roy. Coll. Physicians Lond. 5: 62 (1970).Google Scholar
- 15.Perlmann, P., Perlmann, H., Wigzell, H.: Transpl. Rev. 13: 91 (1972).Google Scholar
- 17.Shear, M. J.: Cancer Res. 1: 731 (1941).Google Scholar