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Nature and Specificity of Human Erythrocyte Membrane Receptor for Bacterial Endotoxins

  • G. F. Springer
  • J. C. Adye
  • A. Bezkorovainy
  • B. Jirgensons

Abstract

Endotoxin (= lipopolysaccharide = LPS1 or O antigen) of gram-negative bacteria in minute quantities produces numerous noxious effects (2, 11), for which attachment to host tissue is a prerequisite. LPS has the ability to fix to human red cells in vitro (cf. 14) and under extreme conditions in vivo (1, 3, 15). A receptor for LPS attachment has been isolated for the first time from the membrane of erythrocytes (17, 18, 19). It interacts with all LPS preparations tested and with the related Kunin antigen but not with other antigens of gram-negative or gram-positive bacteria and hereafter is referred to as LPS-receptor. Other compounds, such as glycolipids, lipoproteins and basic proteins also combine with LPS but are less active and so far as investigated non-specific (23).

Keywords

Sodium Dodecyl Sulfate Sialic Acid Peptide Part Conformational Order Microbial Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1975

Authors and Affiliations

  • G. F. Springer
  • J. C. Adye
  • A. Bezkorovainy
  • B. Jirgensons

There are no affiliations available

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