Nature and Specificity of Human Erythrocyte Membrane Receptor for Bacterial Endotoxins

  • G. F. Springer
  • J. C. Adye
  • A. Bezkorovainy
  • B. Jirgensons


Endotoxin (= lipopolysaccharide = LPS1 or O antigen) of gram-negative bacteria in minute quantities produces numerous noxious effects (2, 11), for which attachment to host tissue is a prerequisite. LPS has the ability to fix to human red cells in vitro (cf. 14) and under extreme conditions in vivo (1, 3, 15). A receptor for LPS attachment has been isolated for the first time from the membrane of erythrocytes (17, 18, 19). It interacts with all LPS preparations tested and with the related Kunin antigen but not with other antigens of gram-negative or gram-positive bacteria and hereafter is referred to as LPS-receptor. Other compounds, such as glycolipids, lipoproteins and basic proteins also combine with LPS but are less active and so far as investigated non-specific (23).


Sodium Dodecyl Sulfate Sialic Acid Peptide Part Conformational Order Microbial Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Boyden, S. V.: Nature (London) 171: 402 (1953).CrossRefGoogle Scholar
  2. 2.
    Braude, A.I., Carey, F. J., Zalesky, M.: J. clinical Invest. 34: 858 (1955).CrossRefGoogle Scholar
  3. 3.
    Buxton, A.: Immunology 2: 203 (1959).PubMedGoogle Scholar
  4. 4.
    Crawford, J. L., Lipscomb, W. N., Schellman, Ch. G.: Proc. Natl. Acad. Sci. U.S. 70: 538 (1973).CrossRefGoogle Scholar
  5. 5.
    French, D., Edsall, J. T.: Advan. Protein Chem. 2: 278 (1945).Google Scholar
  6. 6.
    Gewurz, H., Snyderman, R., Mergenhagen, S. E., Shin, H. S. In: Kadis, S., Weinbaum, G., Ajl, S.: Microbial Toxins, Vol. V., p.127 (Academic Press, New York, N.Y. 1971 ).Google Scholar
  7. 7.
    Gilbert, V.E., Braude, A.E.: J. Exptl. Med. 116: 447 (1962).CrossRefGoogle Scholar
  8. 8.
    Kabat, E. A., Lloyd, K. O., Beychok, S.: Biochemistry 8: 747 (1969).PubMedCrossRefGoogle Scholar
  9. 9.
    Kim, Y.B., Watson, D.W.: Ann. N.Y. Acad. Sci. 133: 727 (1966).PubMedCrossRefGoogle Scholar
  10. 10.
    Lüderitz, O., Galanos, C., Lehmann, V., Nurminen, M., Rietschel, E. T., Rosenfelder, E. T., Simon, M., Westphal, O.: J. Infect. Dis. 128: S17 (1973).CrossRefGoogle Scholar
  11. 11.
    Kadis, S., Weinbaum, G., Ajl, S. J., Ed.: Microbial Toxins, Vol. V., Bacterial Endotoxins (Academic Press, New York, N.Y. 1971 ).Google Scholar
  12. 12.
    Milner, K. C., Rudbach, J.A., Ribi, E.: In: Microbial Toxins, Vol. IV, p 1 (1971).Google Scholar
  13. 13.
    Nakagawa, Y., Capetillo, S., Jirgensons, B.: J. Biol. Chem. 247: 5703 (1972).PubMedGoogle Scholar
  14. 14.
    Neter, E.: Bacteriol. Rev. 20: 166 (1956).PubMedGoogle Scholar
  15. 15.
    Springer, G. F., Horton, R. E.: J. Gen. Physiol. 47: 1229 (1964).PubMedCrossRefGoogle Scholar
  16. 16.
    Springer, G. F., Nagai, Y., Tegtmeyer, H.: Biochemistry 5: 3254 (1966).PubMedCrossRefGoogle Scholar
  17. 17.
    Springer, G. F., Wang, E. T., Nichols, J. H., Shear, J. M.: Ann. N.Y. Acad. Sci. 133 (2): 566 (1966).PubMedCrossRefGoogle Scholar
  18. 18.
    Springer, G. F., Huprikar, S. V., Neter, E.: Infection and Immunity 1: 98 (1970).PubMedGoogle Scholar
  19. 19.
    Springer, G. F., Adye, J. C., Bezkorovainy, A., Murthy, J. R.: J. Infect. Diseases 128: S202 (1973).CrossRefGoogle Scholar
  20. 20.
    Springer, G. F., Adye, J. C., Bezkorovainy, A., Jirgensons, B.: Biochemistry, in press (1973).Google Scholar
  21. 21.
    U.S. Pharmacopoeia XVIII: 886 (1970).Google Scholar
  22. 22.
    Weber, K., Osborn, M.: J. Biol. Chem. 244: 4406 (1969).PubMedGoogle Scholar
  23. 23.
    Whang, H. Y., Neter, E., Springer, G. F.: Z. ImmunForsch. 140: 298 (1970).Google Scholar

Copyright information

© Springer-Verlag/Wien 1975

Authors and Affiliations

  • G. F. Springer
  • J. C. Adye
  • A. Bezkorovainy
  • B. Jirgensons

There are no affiliations available

Personalised recommendations