The Role of Humoral and Cellular Factors in the Stimulation of Nonspecific Resistance Induced by Endotoxin

  • Zs. Pusztai-Markos


The ability of bacterial endotoxins (ET) to alter the course of experimental infections is well-known. The transient increase in homologous and heterologous resistance that develops within hours after ET administration may be related to enhanced macrophage and reticuloendothelial activity (1, 2) and/or to enhancement of preexisting specific antibody titres according to published observations (3, 4). Furthermore, it has been suggested that at least a part of the biological activities provoked by ET are based on a hypersensitivity state of the host (5, 6).


Migration Inhibition Nonspecific Resistance Specific Antibody Titre Male Mouse NMRI Hypersensitivity State 
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© Springer-Verlag/Wien 1975

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  • Zs. Pusztai-Markos

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