The Role of Humoral and Cellular Factors in the Stimulation of Nonspecific Resistance Induced by Endotoxin

  • Zs. Pusztai-Markos


The ability of bacterial endotoxins (ET) to alter the course of experimental infections is well-known. The transient increase in homologous and heterologous resistance that develops within hours after ET administration may be related to enhanced macrophage and reticuloendothelial activity (1, 2) and/or to enhancement of preexisting specific antibody titres according to published observations (3, 4). Furthermore, it has been suggested that at least a part of the biological activities provoked by ET are based on a hypersensitivity state of the host (5, 6).


Migration Inhibition Nonspecific Resistance Specific Antibody Titre Male Mouse NMRI Hypersensitivity State 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Biozzi, G.,Benacerraf, B., Halpern, B. N.:Brit. J. exp. Path. 36: 226 (1955).PubMedGoogle Scholar
  2. 2.
    Rowley, D.,: Adv. Immunol 2: 241 (1962).CrossRefGoogle Scholar
  3. 3.
    Michael, J., G., Whitby, J. L., Landy, M.: Nature 191: 296 (1961).PubMedCrossRefGoogle Scholar
  4. 4.
    Michael, J.,G.: J. exp. Med. 123: 205 (1966).PubMedCrossRefGoogle Scholar
  5. 5.
    Braude, A., I., Siemienski, J.: Bull. N. Y. Acad. Med. 37: 448 (1961).Google Scholar
  6. 6.
    Gingold, J. L., Freedman, H. H.: Proc. Soc. exp. Biol. Med. 128: 599 (1967).Google Scholar
  7. 7.
    David, J. R., David, R. In: In vitro method in cell-mediated immunity, ( Academic Press, New York 1971 ).Google Scholar
  8. 8.
    Britton, S.: Immunology 16: 513 (1969).PubMedGoogle Scholar
  9. 9.
    Collins, F. M., MacKaness, G. B.: J. of Immunol. 101: 830 (1968).Google Scholar
  10. 10.
    Kessel, R. W., Braun, W.: Austr. J. exp. Biol. Med. Sci. 43: 511 (1965).CrossRefGoogle Scholar
  11. 11.
    Heilman, D. H., Bast, R. C.: J. Bact. 93: 15 (1967).PubMedGoogle Scholar
  12. 12.
    Andersson, J., Melchers, F., Galanos, C., Luderitz, O.: J. exp. Med. 137: 943 (1973).PubMedCrossRefGoogle Scholar
  13. 13.
    Peavny, D. I., Shands, J. W., Adler, W. H., Smith, R. T.: J. Immunol. 111: 352 (1973).Google Scholar

Copyright information

© Springer-Verlag/Wien 1975

Authors and Affiliations

  • Zs. Pusztai-Markos

There are no affiliations available

Personalised recommendations