Recent Developments Especially Significant for Ascertaining the Mechanisms of Endotoxin-Enhanced Nonspecific Resistance

  • M. Landy


Of the multitude of effects on the host elicited by endotoxin none have attracted more attention and experimental work than the rapid rise in resistance to a wide variety of microbial pathogens. This enhanced nonspecific resistance to infection can to varying degree be mimicked by agents as diverse as colloidal sulfur, zymosan, heat-aggregated HSA, lipid A, starch granules and the double-stranded polynucleotide poly I C. It is suspected that while particle size and physical characteristics of these diverse agents may be as important for their effects as their composition - as yet no single characteristic of these materials has provided an acceptable explanation for their effects on host resistance. By all criteria — endotoxin displays the most striking effects quantitatively and as its composition, structure and other attributes were well-known and it was widely available it became the most extensive employed agent to study this precocious immunity. The effects of endotoxin on resistance have been shown in infections with fungi, parasites, viruses, Mycobacteria and with gram-positive and gram-negative bacterial pathogens.


Host Resistance Colloidal Sulfur Brucella Abortus Endotoxin Action Thymic Lymphocyte 
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© Springer-Verlag/Wien 1975

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  • M. Landy

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