Intra-Axonal Transport of Transmitters in Mammalian Neurons

  • Annica Dahlström
  • P. O. Heiwall
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 12)


In adrenergic as well as in cholinergic peripheral neurons a proximo-distal transport of the respective neurotransmitters, nor-adrenaline (NA) and acetylcholine (ACh), has been demonstrated (cf. Dahlström and Häggendal, 1966; Dahlström et al., 1974 a). This transport of transmitter molecules from more proximal levels of the neuron to the nerve endings is, in all likelyhood, not necessary to maintain the transmitter levels of the nerve terminals. Since many years it is known that adrenergic (cf. Iversen, 1967) as well as cholinergic (cf. Katz, 1966) nerve terminals possess the capacity for an efficient de novo synthesis of NA and ACh, respectively. The NA and ACh, which is transported distally along axons, may rather be regarded as markers for transported organelles or macromolecules. These organelles or macromolecules in turn may be essential for maintaining the nerve terminal functions, as is probably the case for adrenergic neurons (cf. Dahlström and Häggendal, 1973). Some evidence have recently been obtained in support of the view that similar mechanisms may operate also in cholinergic nerves, but more data need to be obtained. The aim of this presentation is to give a short review of results on neurotransmitter transport in adrenergic and cholinergic neurons.


Sciatic Nerve Nerve Terminal Adrenergic Nerve Adrenergic Neuron Crushed Sciatic Nerve 
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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Annica Dahlström
    • 1
  • P. O. Heiwall
    • 1
  1. 1.Institute of NeurobiologyUniversity of GöteborgGöteborg 33Sweden

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