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Interaction between Adrenergic and Cholinergic Systems: Presynaptic Inhibitory Effect of Noradrenaline on Acetylcholine Release

  • Conference paper
Neurovegetative Transmission Mechanisms

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 11))

Summary

Noradrenaline and adrenaline inhibit acetylcholine release due to nerve activity, through α-adrenoceptors. The inhibition of acetylcholine release by the adrenergic transmitters is, in fact, a rather economical way for the adrenergic (orthosympathetic) nervous system to counteract the parasympathetic nervous system. It is shown that there is a permanent adrenergic control of acetylcholine output. The increase in acetylcholine output after catecholamine depletion or α-blockade of nervous tissue only represents partial removal of an adrenergic restraint. The modulatory role of catecholamines on acetylcholine release mechanism seems to be of physiological importance. Furthermore, it is also shown that acetylcholine may regulate its own release by a negative feedback mechanism. Although this mechanism operates in brain cortex, no such phenomenon, however, was found in the Auerbach plexus.

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References

  • Beani, L., C. Bianchi, and A. Crema: The effect of catecholamines and sympathetic stimulation on the release of acetylcholine from the guinea-pig colon. Br. J. Pharmacol. 36, 1–17 (1968).

    Google Scholar 

  • Bourdois, P. S., J. F. Mitchell, and J. C. Szerb: Effect of atropine on acetylcholine release from cerebral cortical slices stimulated at different frequencies. Br. J. Pharmacol. 42, 640–641 (1971).

    Google Scholar 

  • Bowman, W. C., and C. Raper: Adrenotropic receptors in skeletal muscle. Ann. N.Y. Acad. Sci. 139, 741–753 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Christ, D. D., and S. Nishi: Site of adrenaline blockade in the superior cervical ganglion of the rabbit. J. Physiol. (London) 213, 107–117 (1971).

    CAS  Google Scholar 

  • Chubb, I. W., W. P. De Porter,and A. F. De Schaepdryver: Storage of noradrenaline in sympathetic ganglia. Life Sci. (in press) cit. from De Porter et al. (1972).

    Google Scholar 

  • Dawes, P. M., and E. S. Vizi: Acetylcholine release from the rabbit isolated superior cervical ganglion preparation. Br. J. Pharmacol. 48, 225–232 (1973).

    PubMed  CAS  Google Scholar 

  • Dudar, J. D., and J. C. Szerb: The effect of topically applied atropine on resting and evoked cortical acetylcholine release. J. Physiol. (London) 203, 741–762 (1969).

    CAS  Google Scholar 

  • de Groat, W. C., and W. R. Saum: Sympathetic inhibition of the urinary bladder and of pelvic ganglionic transmission in the cat. J. Physiol. (London) 220, 297–314 (1972).

    Google Scholar 

  • Hadbázy, P.: Effects of isoprenaline and aminophylline on the chronotropic responses of the isolated guinea-pig heart to vagal stimulation and acetylcholine. Br. J. Pharmacol. 42, 364–370 (1971).

    Google Scholar 

  • Hadbázy, P.: “Anticholinergic” action of aminophylline in isolated guinea-pig atria. Eur. J. Pharmacol. 20, 284–286 (1972).

    Article  Google Scholar 

  • Hadbázy, P., and E. S. Vizi: The inhibitory action of noradrenaline on the chronotropic responses to vagal stimulation. (In press.)

    Google Scholar 

  • Hörtnagel, A., H. Hörtnagel, and H. Winkler: Bovine splenic nerve: characterization of noradrenaline-containing vesicles and other cell organelles by density gradient centrfugation. J. Physiol. (London) 205, 103–114 (1969).

    Google Scholar 

  • Kazic, T.: Effect of adrenergic factors on peristalsis and acetylcholine release. Eur. J. Pharmacol. 16, 367–373 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Knoll, J., and E. S. Vizi: Presynaptic inhibition of acetylcholine release by endogenous and exogenous noradrenaline at high rate of stimulation. Br. J. Pharmacol. 40, 554–555 (1970).

    Google Scholar 

  • Knoll, J., and E. S. Vizi: Effect of frequency of stimulation on the inhibition by noradrenaline of the acetylcholine output from parasympathetic nerve terminals. Br. J. Pharmacol. 42, 263–272 (1971).

    PubMed  CAS  Google Scholar 

  • Kosterlitz, H. W., R. J. Lydon, and A. J. Watt: The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α-and β-receptors in the longitudinal muscle of the guinea-pig ileum. Br. J. Pharmacol. 39, 398–413 (1970).

    PubMed  CAS  Google Scholar 

  • Kroneberg, G., A. Oberdorf, and F. Hoffineister: Zur Pharmakologie von 2(2, 6-Dimethylphenylamino)-4H-5,-6-Dihydro-1, 3-thiazin (Bayer 1470), eines Hemmstoff es adrenergischer und cholinergischer Neurone. NaunynSchmiedebergs Arch. Pharmac. exp. Path. 256, 257–280 (1967).

    CAS  Google Scholar 

  • Kuba, K.: Effects of catecholamines on the neuromuscular junction in the rat diaphragm. J. Physiol. 211, 551–570 (1970).

    PubMed  CAS  Google Scholar 

  • Levy, M. N.: Sympathetic-parasympathetic interactions in the heart. Circulation Res. 29, 437–445 (1971).

    PubMed  CAS  Google Scholar 

  • Lindmar, R., K. Löffelholz, and E. Muscholl: Muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents. Br. J. Pharmacol. 32, 280–294 (1968).

    CAS  Google Scholar 

  • Lisscák, K.: Effects of extracts of adrenergic fibers on frog heart. Amer. J. Physiol. 125,778–785 (1939 a).

    Google Scholar 

  • Lissák, K.: Liberation of acetylcholine and adrenaline by stimulating isolated nerves. Amer. J. Physiol. 127,263–271 (1939 b).

    Google Scholar 

  • Malcolm, J. L., P. Saraiva, and J. Spear Phyllis: Cholinergic and adrenergic inhibition in the rat cerebral cortex. Int. J. Neuropharm. 6, 509–527 (1967).

    Article  CAS  Google Scholar 

  • Mitchell, J. F.: The spontaneous and evoked release of acetylcholine from the cerebral cortex. J. Physiol. 165, 98–116 (1963).

    PubMed  CAS  Google Scholar 

  • Paton, W. D. M., and E. S. Vizi: The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip. Br. J. Pharmacol. 35, 10–28 (1969).

    PubMed  CAS  Google Scholar 

  • Polak, R. L.: Effect of hyoscine on the output of acetylcholine into perfused cerebral ventricle of cats. J. Physiol. 181, 317–323 (1965).

    PubMed  CAS  Google Scholar 

  • Porter, W. P., 1. W. De Chubb, and A. F. De Schaepdryver: Pharmacological aspects of peripheral noradrenergic transmission. Arch. Pharmacodyn. 196, suppl., 258–287 (1972).

    Google Scholar 

  • Roth, R. H., L. Stjärne, F. E. Bloom, and N. J. Giarman: Light and heavy norepinephrine storage particles in the rat heart and in bovine splenic nerve. J. Pharmacol. 162, 203–212 (1968).

    CAS  Google Scholar 

  • Scbümann, H. J., K. Schmidt, and A. Philippu: Storage of norpinephrine in sympathetic ganglia. Life Sci. 51, 1809–1815 (1966).

    Article  Google Scholar 

  • Starke, K.: Alpha sympathetic inhibition of adrenergic and cholinergic transmission in the rabbit heart. Arch. Pharmacol. 274, 18–45 (1972).

    Article  CAS  Google Scholar 

  • Szabolcsi, T., E. S. Vizi, and J. Knoll: Inhibition by different drugs of neurochemical transmission in the guinea-pig oesophagus; morphological and functional study. (In press.)

    Google Scholar 

  • Szerb, J. C.: The effect of tertiary and quaternary atropine on cortical acetylcholine output and on the electroencephalogram in cats. Can. J. Physiol. Pharmacol. 42, 303–314 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Szerb, J. C., H. Malik, and E. G. Hunter: Relationship between acetylcholine content and release in the cats cerebral cortex. Can. J. Physiol. Pharmacol. 48, 780–790 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Szerb, J. C., and G. T. Somogyi: Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine. Nature (Biol.) 241, 121–122 (1973).

    CAS  Google Scholar 

  • Tacca, M. Del, S. Lecchini, C. M. Frigo, A. Crema, and C. Benzi: Antagonism of atropine towards endogenous and exogenous acetylcholine before and after sympathetic system blockade in isolated distat guinea-pig colon. Eur. J. Pharmacol. 4, 188–197 (1968).

    Article  PubMed  Google Scholar 

  • Tacca, M. Del, G. Soldani, M. Selli, and A. Crema: Action of catecholamines on release of acetylcholine from human taenia coli. Eur. J. Pharmacol. 9, 80–84 (1970).

    Article  PubMed  Google Scholar 

  • Vizi, E. S.: The inhibitory action of noradrenaline on release of acetylcholine from guinea-pig ileum longitudinal strips. Arch. Pharmacol. 259, 199–200 (1968).

    CAS  Google Scholar 

  • Vizi, E. S.: Inhibition of acetylcholine release by noradrenaline released from sympathetic nerve terminals. In: Abstracts (The 34th Annual Conference of the Hungarian Physiological Society. Debrecen 1968), p. 55. Budapest: Akadémiai Kiadó. 1970.

    Google Scholar 

  • Vizi, E. S.: Stimulation, by inhibition of (Na+-K+-Mg2+)-activated ATP-ase, of acetylcholine release in cortical slices from rat brain. J. Physiol. 226, 95–117 (1972).

    PubMed  CAS  Google Scholar 

  • Vizi, E. S.: Acetylcholine release from guinea-pig ileum by parasympathetic ganglion stimulants and gastrin-like polypeptides. Br. J. Pharmacol. 47, 765–777 (1973).

    PubMed  CAS  Google Scholar 

  • Vizi, E. S., G. Bertaccini, M. Impicciatore, and J. Knoll: Acetylcholine-releasing effect of gastrin and related polypeptides. Eur. J. Pharmacol. 17,175–178 (1972 a).

    Article  PubMed  CAS  Google Scholar 

  • Vizi, E. S., G. Bertaccini, M. Impicciatore, and J. Knoll: Evidence that acetylcholine released by gastrin and related polypeptides contributes to their effect on gastrointestinal motility. Gastroenterology 64, 268 to 277 (1973).

    PubMed  CAS  Google Scholar 

  • Vizi, E. S., and J. Knoll: The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuroeffector transmission; the inhibition of acetylcholine release. J. Pharm. Pharmacol. 23, 918–925 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Vizi, E. S., and J. Knoll: The mechanism of acetylcholine release by nicotine. In: Proc. of symposium on “Experimental tremor” Sarajevo, 1971, pp. 131–150. Sarajevo: Academia of Bosnia and Herzegovina. 1972.

    Google Scholar 

  • Weisbrodt, N. W., C. C. Hug, and P. BassS: Separation of the effects of alpha and beta adrenergic receptor stimulation on taenia coli. J. of Pharmacol. 170, 272–280 (1969).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Semmelweis University of Medicine, H-1085, Budapest, Hungary

    Dr. E. S. Vizi

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  1. Dr. E. S. Vizi
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Editors and Affiliations

  1. Amsterdam, The Netherlands

    J. Ariëns Kappers

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© 1974 Springer-Verlag

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Vizi, E.S. (1974). Interaction between Adrenergic and Cholinergic Systems: Presynaptic Inhibitory Effect of Noradrenaline on Acetylcholine Release. In: Csillik, B., Kappers, J.A. (eds) Neurovegetative Transmission Mechanisms. Journal of Neural Transmission, vol 11. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8341-0_4

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  • DOI: https://doi.org/10.1007/978-3-7091-8341-0_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-8343-4

  • Online ISBN: 978-3-7091-8341-0

  • eBook Packages: Springer Book Archive

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