Interaction between Adrenergic and Cholinergic Systems: Presynaptic Inhibitory Effect of Noradrenaline on Acetylcholine Release

  • E. S. Vizi
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 11)


Noradrenaline and adrenaline inhibit acetylcholine release due to nerve activity, through α-adrenoceptors. The inhibition of acetylcholine release by the adrenergic transmitters is, in fact, a rather economical way for the adrenergic (orthosympathetic) nervous system to counteract the parasympathetic nervous system. It is shown that there is a permanent adrenergic control of acetylcholine output. The increase in acetylcholine output after catecholamine depletion or α-blockade of nervous tissue only represents partial removal of an adrenergic restraint. The modulatory role of catecholamines on acetylcholine release mechanism seems to be of physiological importance. Furthermore, it is also shown that acetylcholine may regulate its own release by a negative feedback mechanism. Although this mechanism operates in brain cortex, no such phenomenon, however, was found in the Auerbach plexus.


Nerve Terminal Vagal Stimulation Cholinergic System Superior Cervical Ganglion Acetylcholine Release 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • E. S. Vizi
    • 1
  1. 1.Department of PharmacologySemmelweis University of MedicineBudapestHungary

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