Skip to main content

The Role of Choline in Maintaining the Fine Structure of Nerve Terminals in the Superior Cervical Ganglion of Cat

  • Conference paper
  • 184 Accesses

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 11))

Summary

The fine structure of synapses was studied in the cat superior cervical ganglion under various experimental conditions. The presence of choline in the performed experiments was found to play an essential role not only in maintaining the intraganglionic nerve transmission, but also in preserving the normal fine structure of presynaptic terminals. Results obtained shed more light on other aspects of the vesicle hypothesis elucidating one of the cellular mechanisms by which the disappearance of synaptic vesicles in stimulated cholinergic nerve terminals could be interpreted.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Birks, R. I.: Effects of stimulation on synaptic vesicles in sympathetic ganglia, as shown by fixation in the presence of Mg’’. J. Physiol. 216, 26–28 P (1971).

    Google Scholar 

  • Bosmann, H. B., and B. A. Hemsworth: Synaptic vesicles. Incorporation of choline by isolated synaptosomes and synaptic vesicles. Biochem. Pharmacol. 19, 133–141 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Brown, G. L., and W. Feldberg: The acetylcholine metabolism of a sympathetic ganglion. J. Physiol. 88, 265–283 (1936).

    PubMed  CAS  Google Scholar 

  • Collier, B., and C. Lang: The metabolism of choline by a sympathetic ganglion. Canad. J. Physiol. Pharmacol. 47, 119–126 (1969).

    Article  CAS  Google Scholar 

  • Collier, B., and F. C. Macintosh: The source of choline for acetylcholine synthesis in a sympathetic ganglion. Canad. J. Physiol. Pharmacol. 47, 127–135 (1969).

    Article  CAS  Google Scholar 

  • Csillik, B., and S. Bense: Function-dependent alterations in the distribution of synaptic vesicles. Acta biol. Acad. Sci. hung. 22, 131–139 (1971).

    CAS  Google Scholar 

  • Csillik, B., and F. Jod: Effect of hemicholinium on the number of synaptic vesicles. Nature (London) 213, 508–509 (1967).

    Article  CAS  Google Scholar 

  • Del Castillo, J., and B. Katz: Biophysical aspects of neuromuscular transmission. Prog. Biophys. 6, 121–170 (1956).

    Google Scholar 

  • De Robertis, E., and A. V. Ferreira: Submicroscopic changes of the nerve endings in the adrenal medulla after stimulation of the splanchnic nerve. J. biophys. biochem. Cytol. 3, 611–614 (1957).

    Article  Google Scholar 

  • Dyachkowa, L. N., J. Hdmori, and L. Fedina:Ultrastructure of synapses in ganglion ciliare of birds after ortho-and antidromic electrical stimulation. Dokl. Acad. Sci. U.S.S.R. 172,957–959 (1967). (In Russian.)

    Google Scholar 

  • Friesen, A. J. D., and J. C. Khatter: Effect of stimulation on synaptic vesicles in the superior cervical ganglion of the cat. Experientia 27, 285–287 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Friesen, A. J. D., G. M. Ling, and M. Nagai: Choline and phospholipid choline in a sympathetic ganglion and their relationship to acetylcholine synthesis. Nature (London) 214, 722–724 (1967).

    Article  CAS  Google Scholar 

  • Hubbard, J. I., and S. Kwanbunbumpen: Evidence for the vesicle hypothesis.. J. Physiol. 194, 407–420 (1968).

    PubMed  CAS  Google Scholar 

  • Jones, S. F., and S. Kwanbunbumpen: The effects of nerve stimulation and hemicholinium on synaptic vesicles at the mammalian neuromuscular junction. J. Physiol. 207, 31–50 (1970).

    PubMed  CAS  Google Scholar 

  • Karnovsky, M. J.: Formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J. Cell Biol. 27, 137 A (1965).

    Google Scholar 

  • Kibjakov, A. V.: Über humorale Übertragung der Erregung von einem Neuron auf das andere. Arch. ges. Physiol. 232, 432–443 (1933).

    Article  Google Scholar 

  • Macintosh, F. C.: Synthesis and storage of acetylcholine in nervous tissue. Can. J. Biochem. Physiol. 41, 2555–2571 (1963).

    Article  CAS  Google Scholar 

  • Millonig, G.: Advantages of a phosphate buffer for 0s04 solutions in fixation. J. appl. Physics. 32, 1637 (1961).

    Google Scholar 

  • Nicolescu, P., M. Dolivo, C. Rouiller, and C. Foroglou-Kerameus: The effect of deprivation of glucose on the ultrastructure and function of the superior cervical ganglion of the rat in vitro. J. Cell Biol. 29, 267–286 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Pdrducz, A., and O. Fehér: Fine structural alterations of presynaptic endings in the superior cervical ganglion of the cat after exhausting preganglionic stimulation. Experientia 26, 629–630 (1970).

    Article  Google Scholar 

  • Pdrducz, A., O. Fehér, and F. Jod: Effects of stimulation and hemicholinium (HC-3) on the fine structure of nerve endings in the superior cervical ganglion of the cat. Brain Res. 34, 61–72 (1971).

    Article  Google Scholar 

  • Paton, W. D. M., and W. L. M. Perry: The relationship between depolarisation and block in the cat’s superior cervical ganglion. J. Physiol. 119, 43–57 (1953).

    PubMed  CAS  Google Scholar 

  • Perri, V., O. Sacchi, E. Raviola, and G. Raviola: Evaluation of the number and distribution of synaptic vesicles at cholinergie nerve-endings after sustained stimulation. Brain Res. 39, 526–529 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Reynolds, E. S.: The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Whittaker, V. P.: The vesicle hypothesis, in: Excitatory Synaptic Mechanisms (Andersen, P., and J. K. S. Jansen, eds.), pp. 67–76. Universitetsforlaget. 1970.

    Google Scholar 

  • Whittaker, V. P.: Origin and function of synaptic vesicles. Ann. New York Acad. Sci. 183, 21–32 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1974 Springer-Verlag

About this paper

Cite this paper

Párducz, Á., Joó, F., Fehér, O. (1974). The Role of Choline in Maintaining the Fine Structure of Nerve Terminals in the Superior Cervical Ganglion of Cat. In: Csillik, B., Kappers, J.A. (eds) Neurovegetative Transmission Mechanisms. Journal of Neural Transmission, vol 11. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8341-0_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-8341-0_18

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-8343-4

  • Online ISBN: 978-3-7091-8341-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics