The Clinical Relevance of Neurohistological Investigations of Intestinal Biopsies

  • G. Lassmann
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 11)


The results of neurohistological investigations of the intestine, performed during the last 2 ½ years are presented. The material is based on 98 rectum biopsies (including 43 showing a normal innervation, 28 of morbus Hirschsprung, 6 of atresia ani, 9 of morbus Down, one of Niemann-Pick, 5 of which cases were accompanied by different cerebral symptoms), 8 duodenal biopsies accompanied by different clinical symptoms, and one surgical specimen of the appendix. The clinical relevance and practical diagnostic value of neurohistological investigations on bioptic material of the intestine is discussed. Besides, the progress in research due to more specific techniques now available is demonstrated. Unsettled problems concerning the local organization of the intramural nervous system (nerve fibres, ganglion cells and enterochromaffin cells) and the neural control of bowel movement are discussed.


Ganglion Cell Rectum Biopsy Intestinal Biopsy Enterochromaffin Cell Afferent Ending 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • G. Lassmann
    • 1
  1. 1.Neurological InstituteUniversity of ViennaWienAustria

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