GABA as a Transmitter in the Central Nervous System of Vertebrates

  • J. Storm-Mathisen
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 11)


The topographical and subcellular distribution of GAD has been studied in Deiters’ nucleus, the cerebellum, hippocampus and substantia nigra, and the effect of lesions of nerve pathways has been examined. The results showed that GAD is localized in Purkinje cells and probably also in neurones confined to the cerebellar cortex. In the hippocampus GAD is localized in intrinsic neurones, some of which are likely to be the basket cells. In the substantia nigra GAD is localized in nerve terminals the density of which may be highest in the pars compacta. The axons to which these terminals belong probably originate in the neostriatum or globus pallidus.

All the available data put together go far towards proving that GABA is the transmitter of the Purkinje cells. They indicate that the same is true for the cerebellar stellate, basket and Golgi cells, the basket cells of the hippocampus, local inhibitory neurones in the cerebral cortex and the striato-nigral fibres. These may be but a small selection of all GABAneurones.


Purkinje Cell Nerve Terminal Cerebellar Cortex Globus Pallidus Mossy Fibre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





choline acetyltransferase




γ-aminobutyric acid


glutamate decarboxylase


inhibitory postsynaptic potential


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. Storm-Mathisen
    • 1
  1. 1.Division for ToxicologyNorwegian Defence Research EstablishmentKjellerNorway

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