Abstract
Generalized spike and wave discharge is one of the most characteristic features of the clinical electroencephalogram. In its classical, regular 3 c/sec form it represents the concomitant of a common form of generalized seizures, the absence attack, which is characterized by a very variable degree of clouding of consciousness and sometimes by minor bilateral motor and autonomic phenomena. No one looking at the electroencephalographic record of such a seizure, be he an expert or a novice, can fail to be impressed by the suddenness with which virtually simultaneously the resting pattern of the electroencephalogram is replaced by high voltage generalized, bilaterally synchronous, rhythmic spike and wave discharge. The cessation of this pattern is equally impressive and so is, often, the symmetry of the waveforms in homologous areas of the hemispheres. Even though the finer analysis of time sequences reveals some lack of perfect synchronization between various areas of the cortex (Petsche 1962), one cannot fail to be impressed by the relative synchronicity of the electrical events. This must imply that a system is being activated which is capable of phase-locking within a relatively narrow range of time-dispersion the discharges of a great number of neurons in widely disparate areas of the brain.
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References
Ajmone Marsan, C., and W. R. Lewis: Pathological findings in patients with “centrencephalic” electroencephalographic patterns. Neurol. 10, 922–930 (1960).
Andersen, P., and J. C. Eccles: Inhibitory phasing of neuronal discharge. Nature (London) 196, 645–647 (1962).
Daly, D., J. L. Whelan, R. G. Bickford, and C. S. Maccarty: The electroencephalogram in cases of tumors of the posterior fossa and third ventricle. Electroenceph. clin. Neurophysiol. 5, 203–216 (1953).
Garretson, H., P. Gloor, and T. Rasmussen: Intracarotid amobarbital and metrazol test for the study of epileptiform discharges in man: a note on its technique. Electroenceph. clin. Neurophysiol. 21, 607–610 (1966).
Gibbs, F. A., and E. L. Gibbs: Atlas of Electroencephalography, Vol. 2. Cambridge, Mass.: Addison-Wesley Press Inc. 1952.
Gloor, P.: Generalized cortico-reticular epilepsies. Some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge. Epilepsia 9, 249–263 (1968).
Gloor, P.: Neurophysiological bases of generalized seizures termed centrencephalic. In: Gastaut, H., H. Jasper, J. Bancaud, and A. Waltregny (eds.), The Physiopathogenesis of the Epilepsies, chapter 18, pp. 209–236. Springfield, Ill.: Charles C. Thomas. 1969.
Gloor, P., O. Kalabay, and N. Giard: The electroencephalogram in diffuse encéphalopathies: electroencephalographic correlates of grey and white matter lesions. Brain 91, 779–802 (1968).
Gloor, P., T. Rasmussen, H. Garretson, and F. Maroun: Fractionized intracarotid Metrazol injection. A new diagnostic method in electroencephalography. Electroenceph. clin. Neurophysiol. 17, 322–327 (1964).
Guerrero-Figueroa, R., A. Barros, F. De Balbian Verster, and R. G. Heath: Experimental “Petit Mal” in kittens. Arch. Neurol. 9, 297–306 (1963).
Hayne, R. A., L. Belinson, and F. A. Gibbs: Electrical activity of subcortical areas in epilepsy. Electroenceph. clin. Neurophysiol. 1, 437–445 (1949).
Hunter, J., and H. H. Jasper: Effects of thalamic stimulation in unanaesthetized animals. Electroenceph. clin. Neurophysiol. 1, 305–324 (1949).
Jasper, H. H., and J. Droogleever-Fortuyn: Experimental studies on the functional anatomy of petit mal epilepsy. Res. Publ. Ass. Nerv. ment. Dis. 26, 272–298 (1947).
Jung, R.: Correlation of bioelectrical and autonomic phenomena with alterations of consciousness and arousal in man. Brain Mechanisms and Consciousness, pp. 310–344. Oxford: Blackwell. 1954.
Kaplan, H., and D. H. Ford: The brain vascular system. Amsterdam: Elsevier. 1966.
Lennox, W. G., E. L. Gibbs, and F. A. Gibbs: Effect on the electroencephalogram of drugs and conditions which influence seizures. Arch. Neurol. Psychiat. 36, 1236–1245 (1936).
Li, C. L., H. Jasper, and L. Henderson: The effect of arousal mechanisms on various forms of abnormality in the electroencephalogram. Electroenceph. clin. Neurophysiol. 4, 512–526 (1952).
Marcus, E. M., and C. W. Watson: Bilateral synchronous spike wave electrographic patterns in the cat. (Interaction of bilateral cortical foci in the intact, the bilateral cortico-callosal and adiencephalic preparation). Arch. Neurol. 14, 601–610 (1966).
Marcus, E. M., and C. W. Watson: Symmetrical epileptogenic foci in monkey cerebral cortex. Arch. Neurol. 19, 99–116 (1968).
Marcus, E. M., C. W. Watson and S. A. Simon: An experimental model of some varieties of petit mal epilepsy. Electrical-behavioral correlations of acute bilateral epileptogenic foci in cerebral cortex. Epilepsia 9, 233–248 (1968a).
Marcus, E. M., C. W. Watson and S. A. Simon: Behavioral correlates of acute bilateral symmetrical epileptogenic foci in monkey cerebral cortex. Brain Res. 9, 370–373 (1968b).
Penfield, W., and H. Jasper: Epilepsy and the functional anatomy of the human brain. Boston: Little, Brown & Co. 1954.
Perot, P.: Mesencephalic-thalamic relations in wave and spike mechanisms, pp. 220. Montreal: Ph. D. Thesis, McGill University. 1963.
Petsche, H.: Pathophysiologie and Klinik des Petit Mals. Toposkopische Untersuchungen zur Phänomenologie des Spike-Wave-Musters. Wien. Z. Nervenh. Grenzgeb. 19, 345–442 (1962).
Pollen, D. A.: Intracellular studies of cortical neurons during thalamic induced wave and spike. Electroenceph. clin. Neurophysiol. 17, 398–404 (1964).
Pollen, D. A., P. Perot, and K. H. Reid: Experimental bilateral wave and spike from thalamic stimulation in relation to level of arousal. Electroenceph. clin. Neurophysiol. 15, 1017–1028 (1963).
Pollen, D. A., K. H. Reid, and P. Perot: Microelectrode studies of experimental 3/sec wave and spike in the cat. Electroenceph. clin. Neurophysiol. 17, 57–67 (1964).
Pollen, D. A. and P. G. Sie: Analysis of thalamic induced wave and spike by modification in cortical excitability. Electroenceph. clin. Neurophysiol. 17, 154–163 (1964).
Prince, D., and D. Farrell: “Centrencephalic” spike-wave discharges following parenteral penicillin injection in the cat. Neurol. 19, 309–310 (1969). (Abstract.)
Rovit, R., P. Gloor, and T. Rasmussen: Intracarotid amobarbital in epilepsy. Arch. Neurol. 5, 606–626 (1961).
Stevens, J. R.: Focal abnormality in petit mal epilepsy. Neurol. 20, 1069–1076 (1970).
Weir, B.: Spike-wave from stimulation of reticular core. Arch. Neurol. 11, 209–218 (1964).
Weir, B.: The morphology of the spike-wave complex. Electroenceph. clin. Neurophysiol. 19, 284–290 (1965).
Weir, B. and P. G. Sie: Extracellular unit activity in cat cortex during the spike-wave complex. Epilepsia 7, 30–43 (1966).
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Gloor, P. (1972). Generalized Spike and Wave Discharges: A Consideration of Cortical and Subcortical Mechanisms of Their Genesis and Synchronization. In: Petsche, H., Brazier, M.A.B. (eds) Synchronization of EEG Activity in Epilepsies. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8306-9_24
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DOI: https://doi.org/10.1007/978-3-7091-8306-9_24
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