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The Chemical Structure of the Normal Human Hemoglobins

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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrès dans la Chimie des Substances Organiques Naturelles

Abstract

The conspicuous red color of the blood has no doubt been a source of wonder, interest, and curiosity ever since it was first observed by man. It followed much later that hemoglobin, the cause of the red color, is neatly packaged in the red blood cells apart from the other constituents of the blood and that it serves as a carrier for oxygen in the body. Not only the oxygen-carrying function of hemoglobin has been the subject of much research but almost every chemical or physiological topic related to hemoglobin has received attention until, at the present time, the literature on hemoglobin is almost overwhelming in amount. No small part of this vast literature has come during the last ten years, since the discovery by Pauling, Itano, Singer, and Wells (99) of the first abnormal human hemoglobin which is now termed sickle-cell anemia hemoglobin or hemoglobin S. This discovery gave a new impetus to the study of hematological disorders for here, for the first time, was a pathological state unquestionably associated with a molecule that is slightly different in some way from the normal one. Because of this difference it is unable to function properly: a molecular disease had been detected. The detection of other abnormal hemoglobins soon followed so that today almost all the letters of the alphabet have been used to designate the various abnormal hemoglobins.

It is a pleasure to acknowledge that during the preparation of this article the author had many stimulating discussions with Dr. Richard T. Jones, Dr. Jerome Vinograd, and Dr. Norman Weliky, and that some of the ideas expressed here arose from these discussions.

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  1. Pasadena, California, USA

    W. A. Schroeder

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  1. California Institute of Technology, Pasadena, USA

    L. Zechmeister

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© 1959 Springer-Verlag in Vienna

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Schroeder, W.A. (1959). The Chemical Structure of the Normal Human Hemoglobins. In: Zechmeister, L. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrès dans la Chimie des Substances Organiques Naturelles. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrès dans la Chimie des Substances Organiques Naturelles, vol 17. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8052-5_7

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  • DOI: https://doi.org/10.1007/978-3-7091-8052-5_7

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