Abstract
Rauwolfia plants contain alkaloids and constitute one of the important series of drugs of vegetable origin. In recent years, Rauwolfia has been the subject of considerable scientific research, particularly for its applications in medicine. It is an important genus of the family Apocynaceae which is characterized by the presence of toxic alkaloids, cardiac glycosides, coumarins and other bitter principles, some of which possess therapeutic value. The most important species of this family which are used in therapy are: Holarrherta antidysenterica Wall (5, 6, 7, 48, 57, 92, 93), commonly known as “kurchi” in India, applied in cases of dysentery; Alstonia scholaris R. Br. (40, 41, 62a, 50) as an antipyretic (73), Apocynum androsaemifolium L. and A. cannabium L. (1, 100) as substitutes for digitalis and as combined tonic diuretics for the treatment of cardiac dropsy; Strophanthus courmontii Franch (61) and Str. kombé Oliv (97) used in cases of cardiac weakness etc.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Allport, N.L.: Chemistry and Pharmacy of Vegetable Drugs. London: Newnes, Ltd. 1943, p. 102.
Allport, N.L. and S.K. Crews: Spectrographic Absorption of Ergometrine in Relation to the British Pharmacopeia Color Test. Quart. J. Pharm. Pharmacol. 8, 447 (1935)
Bader, F. und H. Schwarz: Zur Konstitution des Serpentins. Helv. chim. Acta 35, 1594 (1952).
Bader, F. E.: Die Lage der Doppelbindung im Ring E des Alstonins. Hely. chim. Acta 36, 215 (1953)
Barger, G. und C. Scholz: Über Yohimbin. Helv. chim. Acta 16, 1343 (1933)
Bein, H. J.: Zur Pharmakologie des Reserpins, eines neuen Alkaloides aus Rauwolfia serpentines BENTH. Experientia 9, 107 (1953).
Bertho, A.: Kurchi-Alkaloide. II. Über die Gewinnung von Conessin und dessen Nebenbasen. Arch. Pharmaz. u. Ber. dtsch. pharmaz. Ges. 277, 237 (1939)
Bertho, A.: Kurchi-Alkaloide. III. Über das wirksame Hauptalkaloid Conkurchin. Liebigs Ann. Chem. 555, 214 (1944).
Bertho, A.: Kurchi-Alkaloide. V. Über die Aminobasen Conkurchin und Holarrhimin. Ber. dtsch. chem. Ges. 80, 316 (1947)
Bhatia, B.B. and R.D. Kapur: Pharmacological Action of Alkaloids of R. serpentina BENTH. I. Neo-ajmaline and Iso-amaline J Indian med. Res. 32, 177 (1944).
Bose, S.: Rauwolfinine, the New Alkaloid of the Root of Rauwolfia serpentina BENTH. Science and Culture (India) 48, 98 (1952).
Bose, S.: Rauwolfinine, the New Alkaloid of the Root of Rauwolfia serpentina BENTH. Science and Culture (India) 48, 98 (1952).
Bose, S., Chakravarti, M.D.: A Note on the Pharmacological Action of Rauwolscine. Science and Culture (India) 7, 458 (1942).
Chatterjee(née Mookerjee), A. (in the original papers Nos. II-14, and 17: MoOKERJEE): The Alkaloid of Rauwolfia canescens LINN. I. J. Indian chem. Soc. 18, 33 (1941).
Chatterjee (née Mookerjee), A. (in the original papers Nos. II-14, and 17: MoOKERJEE): The Alkaloid of Rauwolfia canescens Lime. II. J. Indian chem. Soc. 18, 485 (1941).
Chatterjee(née Mookerjee), A. (in the original papers Nos. II-14, and 17: MoOKERJEE): The Alkaloid of Rauwolfia canescens LINN. III. Some Degradation Products of Rauwolscine. J. Indian chem. Soc. 20, 11 (1943).
Chatterjee(née Mookerjee), A. (in the original papers Nos. II-14, and 17: MoOKERJEE): The Alkaloid of Rauwolfia canescens LINN. IV. On the Constitution of Rauwolscine. J. Indian chem. Soc. 23, 6 (1946).
Chatterjee(née Mookerjee), A. (in the original papers Nos. II-14, and 17: MoOKERJEE): The Alkaloid of Rauwolfia canescens LINN. V. J. Indian chem. Soc. 28, 29 ( 1950.
Chatterjee, A. and A. Bhattacharya: On the Active Principles Isolated from the Leaves and Bark of Skimmia laureola HooK. Current Sci. (India) 16, 222 (1947).
Chatterjee, A. and P.K. Bose: On the Constitution of the Alkaloid Isolated from the Bark of Chloroxylon swietenia D. C. J. Indian chem. Soc. 23, 1 (1946).
Chatterjee, A. and S. Bose: Rauwolfinine, the New Alkaloid from the Root of Rauwolfia serpentina BENTH. Science and Culture (India) 17, 139 (1951).
Chatterjee, A. and S. Bose: Studies on the Active Principles Isolated from the Leaves of Aegis marmelos CORREA. J. Indian chem. Soc. 29, 425 (1952).
Chatterjee, A. and S. Bose: Studies on the Active Principles Isolated from the Leaves of Aegis marmelos CORREA. J. Indian chem. Soc. 29, 425 (1952).
Chatterjee, A. and S. Bose: Studies on the Active Principles Isolated from the Leaves of Aegis marmelos CORREA. J. Indian chem. Soc. 29, 425 (1952).
Chatterjee, A., M.D. Chakravartiand I.N. Tayal: Fate of Rauwolscine - an Alkaloid of R. canescens - in the Body (Concentration of Rauwolscine in Blood). Proc. Indian sci. Congr. (33rd) Part III, 187 (1946).
Chatterjee, A. und P. Karrer: Untersuchung über Corynanthein. II. Hely. chim Acta 33, 802 (1950).
Chatterjee, A. and S. Gosh Mazumdar: Alkaloid from Glycosmis pentaphylla CORREA. Science and Culture (India) 17, 306 (1952).
Chatterjee, A. and S. Pakrashi: Yobyrine, the Selenium Dehydrogenation Product of Rauwolscine. Proc. Indian Sci. Congr. (4oth) Part III, p. 355 (1953).
Chatterjee, A. and S. Pakrashi: Yobyrine, the Selenium Dehydrogenation Product of Rauwolscine. Science and Culture (India) 18, 443 (1953).
Chatterjee, A. and S. Pakrashi: Yobyrine, the Selenium Dehydrogenation Product of Rauwolscine. Science and Culture (India) 18, 443 (1953).
Chatterjee, A. and S. Pakrashi: Studies on the Infra-red Spectra of Rauwolscine and its Acetyl Derivative. VII. J. Indian chem. Soc. (1953) (1n press).
Chatterjee, A. and S. Pakrashi: Selenium Di-oxide Oxidation of Yobyrine, the Selenium Dehydrogenation Product of Rauwolscine. VIII. J. Indian chem. Soc. (1953) (in press).
Chaudhuri, R.N., M.N. RAI Chaudhuriand N.K. Chakravorty: Rauwolfia serpentina in Essential Hypertension. Indian med. Gaz. 86, 348 (1951).
Chopra, R.N., B.C. Bose, J.C. Guptaand I.C. Chopra: Alkaloids of Rauwolfia serpentina: A Comparative Study of Their Pharmacological Action and Their Role in Experimental Hypertension. J. Indian med. Res. 30, 319 (1942).
Chopra, R.N. and M.D. Chakravarti: A Preliminary Note on the Pharmacological Action of the Alkaloids of Rauwolfia serpentine BENTH. J. Indian med. Res. 29, 763 (1941)
Chopra, R.N., N.N. Das and S.N. Mukherjee: The Action of Ajmaline on Nerve Impulses. J. Indian med. Res. 24, 1125 (1937).
Chopra, R.N., J.C. Gupta, B.C. Bose and I.C. Chopra: Hypnotic Effect of Rauwolfia serpentine: The Principle Underlying this Action, its Probable Nature. J. Indian med. Res. 31, 71 (1943).
Chopra, R.N., J.C. Gupta and B. Mukherjee: The Pharmacological Action of an Alkaloid Obtained from Rauwolfia serpentine BENTH. J. Indian med. Res. 21, 261 (1933).
Clemo, G.R. and G.A. Swan: The Constitution of Yohimbine. I. J. chem. Soc. ( London ) 1946, 617.
Deger, E.C.: Allgemeine Untersuchung einer von den Indianern gegen Schlangengift und Malaria verwandten Pflanze. Arch. Pharmaz. u. Ber. dtsch. pharmaz. Ges. 275, 496 (1937).
Dewar, M.J.S. and F.E. King: Constitution of Yohimbine. Nature (London) 148, 25 (1941).
Durand, T.H. and B.D. Jackson: Index Kewensis. Oxford: Clarendon Press. Suppl. 1, 358 (1886–1895).
Elderfield, R.C. and A.P. Gray: Alstonia Alkaloids. III. Further Investigation of Alstonine, Reduction, Ozonolysis, and Spectrographic Studies. The Structure of Alstonine. J. org. Chemistry 16, 506 (1951).
Gellert, E. und B. Witkop: Die Identität des Alkaloids Kamassin mit Quebrachamin. Helv. chim. Acta 35, 114 (1952).
Goodson, J. A.: Echitamine in Alstonia Barks. J. chem. Soc. ( London ) 1932, 2626.
Goutarel, R., M.-M. Janot und V. Prelog: Über die Konstitution des Sempervirins. Experientia 4, 24 (1948).
Greshoff, M.: Mittheilungen aus dem chemisch-pharmakologischen Laboratorium des Botanischen Gartens zu Buitenzorg (Java). Ber. dtsch. chem. Ges. 23, 3537 (1890).
Gupta, J.C., S. Ghosh, A.T. Duttaand B.S. Kahali: A Note on the Hypnotic Principle of Rauwolfia serpentine. J. Amer. pharmac. Assoc., Sci. Ed. 36, 416 (1947) •
Gupta, J.C., B.S. Kahaliand A. Dutt: The Hypnotic Effect of a Resin Fraction Isolated from the Root of Rauwolfia serpentine BENTH. Obtained from Dehra Dun. J. Indian med. Res. 32, 183 (1944).
Hahn, G. und A. Hansel: Synthese von 5: 6: 3: 14-Tetrahydro-yobyrinen. Ber. dtsch. chem. Ges. 71, 2192 (1938).
Hahn, G. und H. Werner: Synthese von Tetrahydro-harman (4-Carbolin)Systemen unter physiologischen Bedingungen. III. Synthese des YohimbinGerüstes. Liebigs Ann. Chem. 520, 123 (1935).
Harmsma, A.: Determination of the Absorption Power of Ergot Alkaloids in the Ultraviolet and its Practical Application. Pharmac. Weekbl. 65, 1114 (1928).
Harvey, D.G., E.J. Miller and W. Ronson: The Adamkiewicz, Hopkins and Cole, and Rosenheim Tests for Tryptophan An Investigation of the Configuration of the Organic Molecule Responsible for the Colour Formation and its Bearing on the Constitution of Yohimbine, with a Note on the Action of Formaldehyde on Tryptophan. J. chem. Soc. ( London ) 1941, 153.
Haworth, R.D.: A New Alkaloid from Holarrhena antidysenterica Seeds. J. chem. Soc. ( London ) 1932, 631.
Henry, T.A.: The Plant Alkaloids. 4th ed. Philadelphia and Toronto Blakiston Co. 1949
Hesse, O.: Über die Alkaloide der Ditarine. Liebigs Ann. Chem. 203, 144 (1880).
Hesse, O.: Beitrag zur Kenntnis der australischen Alstoniarinde. Liebigs Ann. Chem. 205, 360 (1880).
Hill, A.W.: Index Kewensis. Oxford: Clarendon Press. Suppl. VI, 172 (1916–1920).
Hill, A.W.: Index Kewensis. Suppl. VII, 205 (1921–1925).
Hill, A.W.: Index Kewensis. Suppl. VIII, 202 (1926–193o).
Hill, A.W.: Index Kewensis. Suppl. IX, 232 (1931–1935).
Hill, A.W. and E.J. Salisbury: Index Kewensis. Suppl. X, 191 (1936–1940).
Hooker, J.D. and B.D. Jacxson: Index Kewensis. 2, 692 (1895).
Irani (Miss), R.J.: Chemistry of Kurchi Seeds. IV. Isolation of Galactose From the Picric Acid Hydrolysis of the Glycoalkaloid. Current Sci. (India) 15, 229 (1946).
Itallie, L. Van and A.J. Steenhauer: Rauwolfia serpentina BENTH. Arch. Pharmaz. u. Ber. dtsch. pharmaz. Ges. 270, 313 (1932).
Jacobs, W.A. and E.L. Gustus: Strophanthin. XVII. Dehydration and Lactone Cleavage in Isostrophanthic Acid Derivatives. J. biol. Chemistry 84, 183 (1929).
Jacobs, W.A. and E.L. Gustus: Strophanthin. XI. The. Hydroxyl Groups of Strophanthidin. J. biol. Chemistry 74, 795 (1927).
Jacoas, W.A. and A. Hoffmann: Strophanthin IX. On Crystalline Kombe Strophanthin. J. biol. Chemistry 67, 609 (1926).
Janot, M.-M., R. Goutarel et J. Massonneau: Structure de la mayumbine. C. R. hebd. Séances Acad. Sci. 234, 850 (1952).
Janot, M.-M., R. Goutarel und V. Prelog: Über die Konstitution des Corynantheins. Heiv. chim Acta 34, 2207 (1951).
Jobst, J. und O. Hesse: Über die Ditarinde. Liebigs Ann. Chem. 178, 49 (1875).
Julian, P.L., W.J. Karpel, A. Magnaniand E.W. Meyer: Studies in the Indole Series. X. Yohimbine, Part 2. The Synthesis of Yobyrine, Yobyrone and “Tetrahydroyobyrine”. J. Amer. chem. Soc. 70, 180 (1948).
Karrer, P. und P. Enslin: Die Konstitution des „Alstyrins“. Hely. chim. Acta 33, 100 (1950).
Karrer, P. und P. Enslin: Untersuchungen übèr Corynanthein. Rely. chim. Acta 32, 1390 (1949).
Karrer, P., R. Schwyzerund A. Flam: Die Konstitution des Corynantheins und Dihydro-corynantheins. Heiv. chim. Acta 35, 851 (1952).
Karrer, P., R. Schwyzer, A. Flamund R. Saemann: Dehydrierung von Yohimbylalkohol mit Selen und Palladium-Kohle. Heir. chim. Acta 35, 865 (1952).
Karschulin, M.: Spectrographic Investigation of Yohimbine. Arch. Hemiju i. Farm. (Yougosl.) 5, 227 (1931).
Kharasch, M.S., D.W. Stanger, M.A. Bloodgoodand R. R. Legault: Spectroscopic Similarity Between Ergot (Lysergic Acid) and the Yohimbine Alkaloids. Science (New York) 83, 36 (1936).
Kirtikar, R.K. and B.D. Basu: Indian Medicinal Plants. II. Bahadurganj, Allahabad (India). 1918, p. 777 (in English).
Koepfli, J.B.: Chemical Investigation of Rauwolfia caftra. I. Rauwolfine. J. Amer. chem. Soc. 54, 2412 (1932).
Leonard, N.J. and R.C. Elderfield: Alstonia Alkaloids. I. Degradation of Alstonine to ß-Carboline Bases and the Reduction of Tetrahydroalstonine with Sodium and Butyl Alcohol. J. org. Chemistry 7, 556 (1942).
Levy, P.R. and R. Robinson: Calycanthidine. Festschrift KARRER, S. 39 (1949)
Mendlik, F. und J.P. Wibaut: Die Dehydrierung des Yohimbins. (Vorl. Mitt.). Recueil Tray. chim Pays-Bas 48, 191 (1929).
Mendlik, F. und J.P. Wibaut: Über Yohimbin (2. Mitt.). Recueil Tray. chim. Pays-Bas 50, 91 (1931).
Merrill, D.E.: The Upper Burma Plants Collected by Captain F Kingdon Ward on the Vernay-Cutting Expedition, 1938–1939. Brittonia 4, 20 (1941).
Müller, JM, E. Schlittler und H.J. Bein: Reserpin, der sedative Wirkstoff aus Rauwolfia serpentina BENTH. Experientia 8, 338 (1952).
Mukerji, B., B.K. Ghosh and L.B. Siddons: Search for Antimalarial Drug in the Indigenous Materia Medica. I. Alstonia scholaris F. BR. Indian med. Gaz. 77, 723 (1942).
Mukherji, D., R. Robinson and E. Schlittler: Chemistry of Ajmaline. Rauwolfine of van Itallie and Steenhauer. Experientia 5, 215 (1949).
Mukherjee, J.: Studies on the Pharmacology of Rauwolscine, the Alkaloid of Rauwolfia canescens LINN. Science and Culture (India) 18, 6 (1952).
Mukherjee, J.: Studies on the Action of Rauwolscine Hydrochloride, the Alkaloid of Rauwolfia canescens LINN., on the Amphibian and Heart Muscles. Indian J. Physiol. and allied Sci. 6, 4 (1953)
Prain, D.: Index Kewensis. Oxford: Clarendon Press. Suppl. III, 149 (i9or1905).
Prain, D.: Index Kewensis. Suppl. IV. 198 (1906–1910).
Prain, D.: Index Kewensis Suppl. V, 214 (1911–1915).
Prelog, V.: Über das Sempervirin. Hely. chim. Acta 31, 588 (1948).
Raymond-Hamet: Ajmalinine, the Alkaloid from Ophioxylum serpentanum WILLD. of Selective Paralyzing Action on Vasoconstrictors Reactive to Adrenaline. Bull. Sci. pharmacol. 43, 364 (1936).
Raymond-Hamet: Sur un nouveau faux Iboga pharmacologiquement actif. C. R. hébd. Séances Acad. Sci. 210, 789 (194o).
Raymond-Hamet: Sur quelques propriétés pharmacologiques d’une drogue alexitère et antimalarique du Guatemala: le chalchupa. C. R. Séances Soc. biol. 129, 462 (1938).
Rindl, M. and P.W.G. Groenewoud: The Chemistry of Rauwolfianatalensis. Trans. Roy. Soc. South Africa 21, 55 (1932).
Robinson, R. and H. Suginome: Experiments on the Synthesis of Physostigmine (Eserine). Part II. Synthesis of a Base which is Believed to be dl-• Noreserethole. J. Chem. Soc. ( London ) 1932, 304.
Rossi, L., A. Del Boca and R. Lobo: Analytical Studies of Yohimbine. IV. A New Colour Reaction for the Recognition of Yohimbine. Anal. farm. bioquim. (Buenos Aires) 3, 51 (1932).
Schlemmer, F. und, H. Schmitt: Spektrographische Untersuchungen über Mutterkorn. I. Die wirksamen Inhaltsstoffe des Mutterkorns. Arch. Pharmaz. u. Ber. dtsch. pharmaz. Ges. 270, 15 (1932).
Schlittler, E. und H. Schwarz: Über das Alkaloid Serpentin aus Rauwolfia serpentina Benth. Helv. chim. Acta 33, 1463 (1950).
Schlittler, E., H. Schwarzund F. Bader: IsolieIung VOn AlstOnin aus afrikanischen Rauwolfia-Arten. Helv. chim. Acta 35, 271 (1952).
Schömer, A.: Estimation of Yohimbine in Corynanthe yohimbi. Pharm. Zentralh. 63, 385 (1922).
Schwarz, H. und E. Schlittler: Über die Konstitution natürlicher und synthetischer quaternärer ß-Carboline, ihre Absorptionsspektren und die Konstitutionsermittlung ihrer Hydrierungsprodukte. Helv. chim Acta 34, 629 (1951).
Sharp, T.M.: The Alkaloids of Alstonia Barks. I. A. constricta F. MUELL. J. chem. Soc. ( London ) 1934, 287.
Sharp, T.M.: The Alkaloids of Alstonia Barks. III. Alstonine. J. chem. Soc. ( London ) 1938, 1353.
Siddiqui, S.: A Note on the Alkaloids of Rauwolfia serpentine BENTH. J. Indian chem. Soc. 16, 421 (1939).
Siddiqui, S. and P.P. Pillay: The Alkaloids of Holarrhena antidysenterica. I. Three New Alkaloids from the Bark of Indian Holarrhena and New Methods of Isolation and Further Purification of Conessine. J. Indian chem. Soc. 9, 553 (1932).
Siddiqui, S. and R.H. Siddiqui: The Alkaloids of Holarrhena antidysenterica. III. Studies in the Action of BrCN on Conessine and its N-Demethylation to iso-Conessimine and Conimine. J. Indian chem. Soc. 11, 787 (1934)
Siddiqui, S. and R.H. Siddiqui: Chemical Examination of the Roots of Rauwolfia serpentine BENTH. J. Indian chem. Soc. 8, 667 (1931).
Siddiqui, S. and R.H. Siddiqui: The Alkaloids of Rauwolfia serpentins BENTH. I. J. Indian chem. Soc. 9, 539 (1932)
Siddiqui, S. and R.H. Siddiqui: The Alkaloids of Rauwolfia serpentins BENTH. II. Studies in the Ajmaline Series. J. Indian chem. Soc. 12, 37 (1935)
Stoll, A., J. Renz und W. Kreis: k-Strophanthosid, das Hauptglucosid der Samen von Strophanthus hombé. Hely. chim. Acta 20, 1484 (1937).
Thiselton-Dyer, W.T.: Index Kewensis. Oxford: Clarendon Press. Suppl. III, 156 (1901–1905).
Webb, L.J.: Guide to the Medicinal and Poisonous Plants of Queensland. Council for sci. and ind. Res., Australia, Bull. No. 232, 19 (1948).
Wehmer, C.: Die Pflanzenstoffe. II. Jena: G. Fischer. 1931, p. 99o.
Wehmer, C.: Die Pflanzenstoffe. II. Jena: G. Fischer. 1931, p. 99o.
Wibaut, J.P. und A.J.P. Van Gastel: Über Yohimbin (3. Mitt.). Recueil Tray. chim. Pays-Bas 54, 85 (1935).
Witkop, B.: Zur Konstitution des Yohimbins und seiner Abbauprodukte. Liebigs Ann. Chem. 654, 83 (1943).
Witkop, B.: On the Stereochemistry of Yohimbine. J. Amer. chem. Soc. 71, 2559 (1949).
Wokes, F. and H. Crocker: Biological and Spectroscopic Tests on Ergot Alkaloids with Notes on the Maurice Smith Colour Test. Quart. J. Pharmac. Pharmacol. 4, 420 (1931).
Woodward, R.B.: Biogenesis of Strychnos Alkaloids. Nature (London) 162, 155 (1948)
Woooward, R.B. and W.M. Mclamore: The Synthesis of Sempervirine Methochloride. J. Amer. chem. Soc. 71, 379 (1949)
Woodward, R.B. and B. Witkop: The Structure of Sempervirine. J. Amer. chem. Soc. 71, 379 (1949)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1953 Springer-Verlag Wien
About this chapter
Cite this chapter
Chatterjee, A. (1953). Rauwolfia Alkaloids. In: Ƶechmeister, L. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progres dans La Chimie des Substances Organiques Naturelles. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progres dans La Chimie des Substances Organiques Naturelles, vol 10. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8003-7_5
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8003-7_5
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8005-1
Online ISBN: 978-3-7091-8003-7
eBook Packages: Springer Book Archive