The Macula pp 57-65 | Cite as

Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration — long term results

  • A. Lappas
  • A. M. H. Foerster
  • A. W. A. Weinberger
  • S. Coburger
  • N. Schrage
  • Bernd Kirchhof


Objectives: To report practicability and efficacy of autologous iris pigment epithelium (IPE) translocation in exudative age-related macular degeneration (ARMD) over one year The consecutive interventional case series included 56 patients with exudative ARMD. During vitrectomy the submacular neovascular membrane (CNV) was removed and IPE cells, harvested from a peripheral iridectomy, were injected into the submacular space. Included were patients with subfoveal occult CNV (11 eyes), classic CNV (10 eyes), mixed CNV (18 eyes), CNV with a pigment epithelial detachment (13 eyes) or with a hemorrhage (5 eyes). Outcome measures were visual acuity, foveal fixation, size of CNV and rate of recurrence based on fluorescence angiographic imaging.

Results: All patients underwent successful surgical removal of the CNV with consecutive subretinal IPE injection. Mean preoperative visual acuity (1.0 +/− 0.3 IogMAR units) did not change significantly after one year (1.0 +/− 0.3 IogMAR units). Ten eyes (17.8%) developed a recurrence. Fixation within the surgically denuded area could be demonstrated in 25 eyes (45%).

Conclusions: Autologous IPE translocation for ARMD over one year can preserve foveal function on a low level, but cannot improve visual acuity. IPE translocation is technically feasible with a low rate of complication. Continued research seems justified to improve functional outcome.


Visual Acuity Retinal Pigment Epithelium Cell Disc Area Postoperative Visual Acuity Preoperative Visual Acuity 
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Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • A. Lappas
    • 1
  • A. M. H. Foerster
    • 2
  • A. W. A. Weinberger
    • 1
  • S. Coburger
    • 3
  • N. Schrage
    • 1
  • Bernd Kirchhof
    • 1
  1. 1.Department of OphthalmologyUniversity of AachenAachenGermany
  2. 2.Department of OphthalmologyUniversity of CologneCologneGermany
  3. 3.Department of Medical Statistics, Informatics and EpidemiologyUniversity of CologneCologneGermany

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