The Macula pp 293-298 | Cite as

Epi-retinal prosthesis

  • Eugene de JuanJr
  • J. D. Weiland
  • M. S. Humayun
  • G. Y. Fujii


Retinitis pigmentosa (RP) and age-related macula degeneration (AMD) lead to the degeneration of photoreceptors, resulting in a significant visual deficit for the afflicted individual [1]. Research is proceeding to investigate the feasibility of replacing the function of the photoreceptors with an electronic device [2, 3]. The photoreceptors initiate a neural signal in response to light. The experiments to be discussed investigate the possibility of using electrical signals (generated by a retinal prosthesis) to initiate a neural response in the remaining cells of the retina. Results from both animal and human research conducted over the past decade have established the following: Intraocular stimulating electrodes can evoke focal responses that correlate with the stimulus position and timing [4–6], the inner retina in RP and AMD is relatively unharmed even when the outer retina is severely degenerated [7–9], and a device can be implanted on the surface of the retina without causing significant damage to the retina [10, 11]. Based on these preliminary trials, an FDA approved clinical trial was intiated to assess safety of implantation of an epiretinal device in humans blind from retinitis pigmentosa. 2 human volunteers have used permanently implanted devices to detect ambient light and sense motion. Based on these encouraging results, the current focus is being shifted from feasibility studies to the development of an implantable, electronic device, which will be capable of stimulating the retina at hundreds of individual points.


Retinitis Pigmentosa Cochlear Implant Electrode Array Pattern Recognition Task Retinal Prosthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Heckenlively JR, Boughman J, Friedman L (1988) Diagnosis and classification of retinitis pigmentosa. In: Heckenlively JR (ed) Retinitis pigmentosa. Philadelphia, PA: JB Lippincott, 21Google Scholar
  2. 2.
    Zrenner E (2002) Will retinal implants restore vision? Science 295 (5557): 1022–5PubMedCrossRefGoogle Scholar
  3. 3.
    Margalit E, Maia M, Weiland JD, Greenberg RJ, Fujii GY, Torres G, et al (2002) Retinal prosthesis for the blind. Sury Ophthalmol 47 (4): 335–56CrossRefGoogle Scholar
  4. 4.
    Humayun MS,, de Juan EJ, Weiland JD, Dagnelie G, Katona S, Greenberg RJ et al (1999) Pattern electrical stimulation of the human retina. Vision Research 39: 2569–76PubMedCrossRefGoogle Scholar
  5. 5.
    Weiland JD, Humayun MS, Dagnelie G, de Juan JE, Jr., Greenberg RJ, Iliff NT (1999) Understanding the origin of visual percepts elicited by electrical stimulation of the human retina. Graefes Arch Clin Exp Ophthalmol 237 (12): 1007–13PubMedCrossRefGoogle Scholar
  6. 6.
    Rizzo J, Wyatt J, Loewenstein J, Kelly S (2000) Acute intraocular retinal stimulation in normal and blind humans. ARVO abstracts [532]Google Scholar
  7. 7.
    Stone JL, Barlow WE, Humayun MS, de Juan EJ, Milam AH (1992) Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa. Arch Ophthalmol 110(111: 1634–9Google Scholar
  8. 8.
    Santos A, Humayun MS,, de Juan EJ, Greenburg RJ, Marsh MJ, Klock IB et al (1997) Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch Ophthalmol 115 (4): 511–15PubMedCrossRefGoogle Scholar
  9. 9.
    Kim S, Sadda S, Pearlman J, Humayun M, de Juan EJ, Melia M, et al (2001) Morphometric analysis of the macula in eyes with disciform age-related macular degeneration. Arch Ophthalmol (Submitted )Google Scholar
  10. 10.
    Majji AB, Humayun MS, Weiland JD, Suzuki S, D’Anna SA, de Juan JE Jr (1999) Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs. Invest Ophthalmol Vis Sci 40 (9): 2073–81PubMedGoogle Scholar
  11. 11.
    Margalit E, Fujii G, Lai J, Gupta P, Chen S, Shyu J, et al (2000) Bioadhesives for intraocular use. Retina 20: 469–77PubMedGoogle Scholar
  12. 12.
    House WF (1976) Cochlear implants. Ann Otol Rhino! Laryngol 85 [Suppl 271 (3Pt2): 1–93Google Scholar
  13. 13.
    Cha K, Horch K, Normann RA (1992) Simulation of a phosphene-based visual field: visual acuity in a pixelized vision system. Ann Biomed Eng 20 (4): 439–49PubMedCrossRefGoogle Scholar
  14. 14.
    Veraart C, Raftopoulos C, Mortimer JT, Delbeke J, Pins D, Michaux G, et al (1998) Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode. Brain Res 813 (1): 181–6PubMedCrossRefGoogle Scholar
  15. 15.
    Schmidt EM, Bak MJ, Hambrecht FT, Kufta CV, O’Rourke DK, Vallabhanath P (1996) Feasibility of a visual prosthesis for the blind based on intracortical microstimulation of the visual cortex. Brain 119 (Pt 2): 507–22PubMedCrossRefGoogle Scholar
  16. 16.
    Butler LD, Stieglitz TL (1993) Contagion in schizophrenia: a critique of Crow and Done (1986). Schizophr Bull 19 (3): 449–54PubMedGoogle Scholar
  17. 17.
    Blau A, Ziegler C, Heyer M, Endres F, Schwitzgebel G, Matthies T, et al (1997) Characterization and optimization of microelectrode arrays for in vivo nerve signal recording and stimulation. Biosens Bioelectron 12 (9–10): 883–92PubMedCrossRefGoogle Scholar
  18. 18.
    Thielecke H, Stieglitz T, Beutel H, Matthies T, Ruf HH, Meyer JU (1999) Fast and precise positioning of single cells on planar electrode substrates. IEEE Eng Med Biol Mag 18 (6): 48–52PubMedCrossRefGoogle Scholar
  19. 19.
    Rizzo J, Wyatt J (1997) Prospects for a visual prosthesis. Neuroscientist 3: 251–62CrossRefGoogle Scholar
  20. 20.
    Zrenner E, Miliczek KD, Gabel VP, Graf HG, Guenther E, Haemmerle H, et al (1997) The development of subretinal microphotodiodes for replacement of degenerated photoreceptors [see comments]. Ophthalmic Res 29 (5): 269–80PubMedCrossRefGoogle Scholar
  21. 21.
    Eckmiller R (1997) Learning retina implants with epiretinal contacts. Ophthalmic Res 29 (5): 281–9PubMedCrossRefGoogle Scholar
  22. 22.
    Chow AY, Chow VY (1997) Subretinal electrical stimulation of the rabbit retina. Neurosci Lett 225 (1): 13–16PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • Eugene de JuanJr
    • 1
  • J. D. Weiland
    • 1
  • M. S. Humayun
    • 1
  • G. Y. Fujii
    • 1
  1. 1.The Retina Institute, Doheny Eye InstituteUniversity of Southern CaliforniaLos AngelesUSA

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