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The Macula pp 17-25 | Cite as

The importance of maintaining the RPE phenotype in retinal transplantation

  • Mike Boulton

Abstract

Retinal degeneration is a major cause of visual loss and is associated with a variety of conditions (e.g. age-related macular degeneration (AMD), retinitis pigmentosa, macular dystrophy). Morphologically, such degeneration can occur in the neural retina (e.g. retinitis pigmentosa) or retinal pigment epithelium (e.g. AMD). While a number of therapies have been proposed for the treatment of retinal degeneration, transplantation of cells or tissue has received considerable attention in the last decade [18, 20]. Of particular interest is retinal pigment epithelium (RPE) transplantation which has the advantage over neural retinal transplantation that it only involves one cell type, does not require neural networking and is a reasonably straightforward procedure, although not without complications as will be discussed later.

Keywords

Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Retinal Degeneration Photoreceptor Outer Segment Human Retinal Pigment Epithelium Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  1. 1.School of Optometry and Vision SciencesCardiff UniversityCardiffUK

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