Fundus autofluorescence mapping using a confocal scanning laser ophthalmoscope
Visualization of the retinal pigment epithelium (RPE) in vivo has proven difficult in the past for various reasons, including the optical properties of the eye and the small size of the cellular elements, forming a single layer between the neurosensory retina and Bruch’s membrane. With the advent of scanning laser ophthalmoscopy it is now possible to image topographic distribution and intensity of fundus autofluorescence (AF) derived from accumulations of lipofuscin (LF) in the lysosomal compartment of RPE cells. Excessive lipofuscin storage in the RPE cytoplasm occurs not only in association with age but also with many hereditary and degenerative retinal diseases including age-related macular degeneration (AMD), Stargardt disease, Best disease, and pattern dystrophies. It represents a common pathogenetic downstream pathway for various heterogenous etiologies.
KeywordsRetinal Pigment Epithelium Macular Hole Geographic Atrophy Fundus Autofluorescence Stargardt Disease
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