The Macula pp 139-147 | Cite as

Photodynamic therapy (PDT) in eyes with pathologic myopia

  • Ilse Krebs
  • Susanne Binder
  • U. Stolba
  • A. Abri


Pathologic Myopia has been reported to be a major cause of blindness, especially in younger patients [1]. Pathologic myopia is characterized by excessive axial length and secondary degenerative changes in the periphery and in the posterior pole. Choroidal neovascularisation (CNV) occurs in 5–10% [2, 3] of these patients and extends under the centre of the foveal avascular zone in about 50% [4, 5]. Thermal photocoagulation of subfoveal CNV results in an immediate permanent decrease of vision with an absolute scotoma in the centre [6, 7]. Two multicenter, double-masked, placebo-controlled, randomised clinical trials-the Verteporfin in Photodynamic Therapy Study (VIP-study) [8] and the Treatment of Age-related Macular Degeneration With Photodynamic Therapy Study (TAP-study) [9] showed a better outcome for distance acuity in cases of pathologic myopia than in cases with age-related macular degeneration (AMD). The purpose of our study was to examine more precisely a series of eyes with pathologic myopia and sCNV treated with PDT and work out characteristics of the myopic membranes.


Optical Coherence Tomography Photodynamic Therapy Retinal Thickness Choroidal Neovascularization Distance Acuity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Krumpaszky HG, Haas A, Klauss V, Selbmann HK (1997) New blindness incidents in Wurttemberg-Hohenzollern. Ophthalmologe 94 (3): 234–6PubMedCrossRefGoogle Scholar
  2. 2.
    Curtin BJ, Karlin DB (1971) Axial length measurements and fundus changes of the myopic eye. Am J Ophthalmol 1 (1 Part 1): 42–53Google Scholar
  3. 3.
    Curtin BJ (1979) Physiologic vs pathologic myopia: genetics vs environment. Ophthalmology 86 (5): 681–91PubMedGoogle Scholar
  4. 4.
    Tabandeh H, Flynn HW Jr, Scott IU, Lewis ML, Rosenfeld PJ, Rodriguez F, Rodriguez A, Singer-man LJ, Schiffman J (1999) Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization. Ophthalmology 106 (11): 2063–7PubMedCrossRefGoogle Scholar
  5. 5.
    Avila MP, Weiter JJ, Jalkh AE, Trempe CL, Pruett RC, Schepens CL (1984) Natural history of choroidal neovascularization in degenerative myopia. Ophthalmology 91 (12): 1573–81PubMedGoogle Scholar
  6. 6.
    Soubrane G, Pison J, Bornert P, Perrenoud F, Coscas G (1986) Subretinal neovessels in degenerative myopia: results of photocoagulation. Bull Soc Ophtalmol Fr 86 (3): 269–72PubMedGoogle Scholar
  7. 7.
    Macular Photocoagulation Study Group (1991) Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the macular photocoagulation study. Arch Ophthalmol 109 (9): 1242–57CrossRefGoogle Scholar
  8. 8.
    Verteporfin in Photodynamic Therapy (VIP) Study Group (2001) Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin. 1-year results of a randomized clinical trial—VIP report no. 1. Ophthalmology 108 (5): 841–52CrossRefGoogle Scholar
  9. 9.
    Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials—TAP report. Arch Ophthalmol 117 (10): 1329–45Google Scholar
  10. 10.
    Hotchkiss ML, Fine SL (1981) Pathologic myopia and choroidal neovascularization. Am J Ophthalmol 91 (2): 177–83PubMedGoogle Scholar
  11. 11.
    Secretan M, Kuhn D, Soubrane G, Coscas G (1997) Long-term visual outcome of choroidal neovascularization in pathologic myopia: natural history and laser treatment. Eur J Ophthalmol 7 (4): 307–16PubMedGoogle Scholar
  12. 12.
    Ferris Fld, Kassoff A, Bresnick Gh, et al (1982) New visual acuity charts for clinical research. Am J Ophthalmol 94: 91–6Google Scholar
  13. 13.
    Jaakkola A, Vesti E, Immonen I (1998) Correlation between Octopus perimetry and fluorescein angiography after strontium-90 plaque brachytherapy for subfoveal exudative age related macular degeneration. Br J Ophthalmol 82 (7): 763–8PubMedCrossRefGoogle Scholar
  14. 14.
    Ito A, Kawabata H, Fujimoto N, Adachi-Usami E (2001) Effect of myopia on frequency-doubling perimetry. Invest Ophthalmol Vis Sci 42 (5): 1107–10PubMedGoogle Scholar
  15. 15.
    Sunness JS, Applegate CA, Haselwood D, Rubin GS (1996) Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. Ophthalmology 103 (9): 1458–66PubMedGoogle Scholar
  16. 16.
    Trauzettel-Klosinski S, Tornow RP (1996) Fixation behavior and reading ability in macular Scotoma Neuro-ophthalmology 16 (4): 241–53Google Scholar
  17. 17.
    Guez JE, Le Gargasson JF, Rigaudiere F, O’Regan JK (1993) Is there a systematic location for the pseudo-fovea in patients with central scotoma? Vision Res 33 (9): 1271–9PubMedCrossRefGoogle Scholar
  18. 18.
    Hee MR, Baumal CR, Puliafito CA, Duker JS, Reichel E, Wilkins JR, Coker JG, Schuman JS, Swanson EA, Fujimoto JG (1996) Optical coherence tomography of age-related macular degeneration and choroidal neovascularization. Ophthalmology 103 (8): 1260–70PubMedGoogle Scholar
  19. 19.
    Hee MR, Izatt JA, Swanson EA, Huang D, Schuman JS, Lin CP, Puliafito CA, Fujimoto JG (1995) Optical coherence tomography of the human retina. Arch Ophthalmol 113 (3): 325–32PubMedCrossRefGoogle Scholar
  20. 20.
    Hee MR, Puliafito CA, Wong C, Duker JS, Reichel E, Rutledge B, Schuman JS, Swanson EA, Fujimoto JG (1995) Quantitative assessment of macular edema with optical coherence tomography. Arch Ophthalmol 113 (8): 1019–29PubMedCrossRefGoogle Scholar
  21. 21.
    Puliafito CA, Hee MR, Lin CP, Reichel E, Schuman JS, Duker JS, Izatt JA, Swanson EA, Fujimoto JG (1995) Imaging of macular diseases with optical coherence tomography. Ophthalmology 102 (2): 217–29PubMedGoogle Scholar
  22. 22.
    Zolf R, Glacet-Bernard A, Benhamou N, Mimoun G, Coscas G, Soubrane G (2002) Imaging analysis with optical coherence tomography: relevance for submacular surgery in high myopia and in multifocal choroiditis. Retina 22 (2): 192–201PubMedCrossRefGoogle Scholar
  23. 23.
    Jurklies B, Weismann M, Husing J, Sutter EE, Bornfeld N (2002) Monitoring retinal function in neovascular maculopathy using multifocal electroretinography — early and long-term correlation with clinical findings. Graefes Arch Clin Exp Ophthalmol 240 (4): 244–64PubMedCrossRefGoogle Scholar
  24. 24.
    Kawabata H, Adachi-Usami E (1997) Multifocal electroretinogram in myopia. Invest Ophthalmol Vis Sci 38 (13): 2844–51PubMedGoogle Scholar
  25. 25.
    Seeliger MW, Jurklies B, Kellner U, Palmowski A, Bach M, Kretschmann U (2001) Multifocal electroretinography (mfERG). Ophthalmologe 98 (11): 1112–27PubMedCrossRefGoogle Scholar
  26. 26.
    Terasaki H, Miyake Y, Niwa T, Ito Y, Suzuki T, Kikuchi M, Kondo M (2002) Focal macular electroretinograms before and after removal of choroidal neovascular lesions. Invest Ophthalmol Vis Sci 43 (5): 1540–5PubMedGoogle Scholar
  27. 27.
    Thölen A, Bernasconi P, Fierz A, Messmer E (2001) Lesefähigkeit nach photodynamischer Therapie ( PDT) für altersabhängige Makuladegeneration and für hohe Myopie. Der Ophthalmologe [Suppl l]Google Scholar

Copyright information

© Springer-Verlag/Wien 2004

Authors and Affiliations

  • Ilse Krebs
    • 1
  • Susanne Binder
    • 1
  • U. Stolba
    • 1
  • A. Abri
    • 1
  1. 1.Department of Ophthalmology, The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser SurgeryRudolf Foundation HospitalViennaAustria

Personalised recommendations