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Photodynamic therapy (PDT) in eyes with pathologic myopia

  • Chapter
The Macula

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Abstract

Pathologic Myopia has been reported to be a major cause of blindness, especially in younger patients [1]. Pathologic myopia is characterized by excessive axial length and secondary degenerative changes in the periphery and in the posterior pole. Choroidal neovascularisation (CNV) occurs in 5–10% [2, 3] of these patients and extends under the centre of the foveal avascular zone in about 50% [4, 5]. Thermal photocoagulation of subfoveal CNV results in an immediate permanent decrease of vision with an absolute scotoma in the centre [6, 7]. Two multicenter, double-masked, placebo-controlled, randomised clinical trials-the Verteporfin in Photodynamic Therapy Study (VIP-study) [8] and the Treatment of Age-related Macular Degeneration With Photodynamic Therapy Study (TAP-study) [9] showed a better outcome for distance acuity in cases of pathologic myopia than in cases with age-related macular degeneration (AMD). The purpose of our study was to examine more precisely a series of eyes with pathologic myopia and sCNV treated with PDT and work out characteristics of the myopic membranes.

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References

  1. Krumpaszky HG, Haas A, Klauss V, Selbmann HK (1997) New blindness incidents in Wurttemberg-Hohenzollern. Ophthalmologe 94 (3): 234–6

    Article  PubMed  CAS  Google Scholar 

  2. Curtin BJ, Karlin DB (1971) Axial length measurements and fundus changes of the myopic eye. Am J Ophthalmol 1 (1 Part 1): 42–53

    Google Scholar 

  3. Curtin BJ (1979) Physiologic vs pathologic myopia: genetics vs environment. Ophthalmology 86 (5): 681–91

    PubMed  CAS  Google Scholar 

  4. Tabandeh H, Flynn HW Jr, Scott IU, Lewis ML, Rosenfeld PJ, Rodriguez F, Rodriguez A, Singer-man LJ, Schiffman J (1999) Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization. Ophthalmology 106 (11): 2063–7

    Article  PubMed  CAS  Google Scholar 

  5. Avila MP, Weiter JJ, Jalkh AE, Trempe CL, Pruett RC, Schepens CL (1984) Natural history of choroidal neovascularization in degenerative myopia. Ophthalmology 91 (12): 1573–81

    PubMed  CAS  Google Scholar 

  6. Soubrane G, Pison J, Bornert P, Perrenoud F, Coscas G (1986) Subretinal neovessels in degenerative myopia: results of photocoagulation. Bull Soc Ophtalmol Fr 86 (3): 269–72

    PubMed  CAS  Google Scholar 

  7. Macular Photocoagulation Study Group (1991) Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the macular photocoagulation study. Arch Ophthalmol 109 (9): 1242–57

    Article  Google Scholar 

  8. Verteporfin in Photodynamic Therapy (VIP) Study Group (2001) Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin. 1-year results of a randomized clinical trial—VIP report no. 1. Ophthalmology 108 (5): 841–52

    Article  Google Scholar 

  9. Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials—TAP report. Arch Ophthalmol 117 (10): 1329–45

    Google Scholar 

  10. Hotchkiss ML, Fine SL (1981) Pathologic myopia and choroidal neovascularization. Am J Ophthalmol 91 (2): 177–83

    PubMed  CAS  Google Scholar 

  11. Secretan M, Kuhn D, Soubrane G, Coscas G (1997) Long-term visual outcome of choroidal neovascularization in pathologic myopia: natural history and laser treatment. Eur J Ophthalmol 7 (4): 307–16

    PubMed  CAS  Google Scholar 

  12. Ferris Fld, Kassoff A, Bresnick Gh, et al (1982) New visual acuity charts for clinical research. Am J Ophthalmol 94: 91–6

    Google Scholar 

  13. Jaakkola A, Vesti E, Immonen I (1998) Correlation between Octopus perimetry and fluorescein angiography after strontium-90 plaque brachytherapy for subfoveal exudative age related macular degeneration. Br J Ophthalmol 82 (7): 763–8

    Article  PubMed  CAS  Google Scholar 

  14. Ito A, Kawabata H, Fujimoto N, Adachi-Usami E (2001) Effect of myopia on frequency-doubling perimetry. Invest Ophthalmol Vis Sci 42 (5): 1107–10

    PubMed  CAS  Google Scholar 

  15. Sunness JS, Applegate CA, Haselwood D, Rubin GS (1996) Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. Ophthalmology 103 (9): 1458–66

    PubMed  CAS  Google Scholar 

  16. Trauzettel-Klosinski S, Tornow RP (1996) Fixation behavior and reading ability in macular Scotoma Neuro-ophthalmology 16 (4): 241–53

    Google Scholar 

  17. Guez JE, Le Gargasson JF, Rigaudiere F, O’Regan JK (1993) Is there a systematic location for the pseudo-fovea in patients with central scotoma? Vision Res 33 (9): 1271–9

    Article  PubMed  CAS  Google Scholar 

  18. Hee MR, Baumal CR, Puliafito CA, Duker JS, Reichel E, Wilkins JR, Coker JG, Schuman JS, Swanson EA, Fujimoto JG (1996) Optical coherence tomography of age-related macular degeneration and choroidal neovascularization. Ophthalmology 103 (8): 1260–70

    PubMed  CAS  Google Scholar 

  19. Hee MR, Izatt JA, Swanson EA, Huang D, Schuman JS, Lin CP, Puliafito CA, Fujimoto JG (1995) Optical coherence tomography of the human retina. Arch Ophthalmol 113 (3): 325–32

    Article  PubMed  CAS  Google Scholar 

  20. Hee MR, Puliafito CA, Wong C, Duker JS, Reichel E, Rutledge B, Schuman JS, Swanson EA, Fujimoto JG (1995) Quantitative assessment of macular edema with optical coherence tomography. Arch Ophthalmol 113 (8): 1019–29

    Article  PubMed  CAS  Google Scholar 

  21. Puliafito CA, Hee MR, Lin CP, Reichel E, Schuman JS, Duker JS, Izatt JA, Swanson EA, Fujimoto JG (1995) Imaging of macular diseases with optical coherence tomography. Ophthalmology 102 (2): 217–29

    PubMed  CAS  Google Scholar 

  22. Zolf R, Glacet-Bernard A, Benhamou N, Mimoun G, Coscas G, Soubrane G (2002) Imaging analysis with optical coherence tomography: relevance for submacular surgery in high myopia and in multifocal choroiditis. Retina 22 (2): 192–201

    Article  PubMed  Google Scholar 

  23. Jurklies B, Weismann M, Husing J, Sutter EE, Bornfeld N (2002) Monitoring retinal function in neovascular maculopathy using multifocal electroretinography — early and long-term correlation with clinical findings. Graefes Arch Clin Exp Ophthalmol 240 (4): 244–64

    Article  PubMed  CAS  Google Scholar 

  24. Kawabata H, Adachi-Usami E (1997) Multifocal electroretinogram in myopia. Invest Ophthalmol Vis Sci 38 (13): 2844–51

    PubMed  CAS  Google Scholar 

  25. Seeliger MW, Jurklies B, Kellner U, Palmowski A, Bach M, Kretschmann U (2001) Multifocal electroretinography (mfERG). Ophthalmologe 98 (11): 1112–27

    Article  PubMed  CAS  Google Scholar 

  26. Terasaki H, Miyake Y, Niwa T, Ito Y, Suzuki T, Kikuchi M, Kondo M (2002) Focal macular electroretinograms before and after removal of choroidal neovascular lesions. Invest Ophthalmol Vis Sci 43 (5): 1540–5

    PubMed  Google Scholar 

  27. Thölen A, Bernasconi P, Fierz A, Messmer E (2001) Lesefähigkeit nach photodynamischer Therapie ( PDT) für altersabhängige Makuladegeneration and für hohe Myopie. Der Ophthalmologe [Suppl l]

    Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery, Rudolf Foundation Hospital, Juchgasse 25, A-1030, Vienna, Austria

    Ilse Krebs M.D., Prof. Dr. Susanne Binder, U. Stolba & A. Abri

Authors
  1. Ilse Krebs M.D.
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  2. Prof. Dr. Susanne Binder
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  3. U. Stolba
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  4. A. Abri
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Editor information

Editors and Affiliations

  1. The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery, Department of Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria

    Susanne Binder

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© 2004 Springer-Verlag/Wien

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Krebs, I., Binder, S., Stolba, U., Abri, A. (2004). Photodynamic therapy (PDT) in eyes with pathologic myopia. In: Binder, S. (eds) The Macula. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7985-7_17

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  • DOI: https://doi.org/10.1007/978-3-7091-7985-7_17

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7987-1

  • Online ISBN: 978-3-7091-7985-7

  • eBook Packages: Springer Book Archive

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