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Tolerance is a condition sine qua non in life: its relation to transplantation

  • S. Panzer
Part of the Intensivmedizinisches Seminar book series (INTENSIVM.SEM., volume 8)

Abstract

The shortage of human donor organs for transplantation has induced a resurgence of interest in xenotransplantation. For this approach vascularized transplants (heart, kidney, liver) and tissue (islet cells) are considered [1]. Moreover, it became clear that HIV infection cannot be controlled by classical ways of treatment modalities. Hematopoiesis from animal donors resistent to HIV, which would allow human survival, is a fascinating indication for xenotransplantation to humans [8].

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References

  1. 1.
    Auchincloss H (1988) Xenogeneic transplantation. A review. Transplantation 45: 1–20CrossRefGoogle Scholar
  2. 2.
    Bach FH, Blakely ML, Van der Werft WJ, Vanhove B, Stuhlmeier K, de Martin R, Winkler H (1994) Xenotransplantation: problems posed by endothelial cell activation. Transplant Proc 26: 1029–1030Google Scholar
  3. 3.
    Langford GA, Yannoutsos N, Cozzi E, Lancaster R, Elsome K, Chen P, Richards A, White DJG (1994) Production of pigs transgenic for human decay accelarating factor. Transplant Proc 26: 1400–1401PubMedGoogle Scholar
  4. 4.
    Loveland BE, Syokolai K, Johnstone RW, McKenzie IFC (1994) Coordinate functions of multiple complement regulating molcules, CD46, CD5 5, and CD59-Transplant Proc 26: 1070–1071Google Scholar
  5. 5.
    Panzer S, Geller RL, Bach FH (1990) Purified human T cells stimulated with cross-linked anti-CD3 monoclonal antibody OKT/3:rIL-l is a co-stimulatory factor for CD4+CD29+CD45RA-T cells. Scand J Immunol 32: 359–371PubMedCrossRefGoogle Scholar
  6. 6.
    Panzer S, Madden M, Matsuki K (1993) Interaction of IL-l(3, IL-6 and tumor necrosis factor-alpha ( TNF-OC) in human T cells activated by murine antigens. Clin Exp Immunol 93: 471–478Google Scholar
  7. 7.
    Piatt JL, Vercerlotti GM, Dalmasso AP, Mata AJ, Bolman RM, Najarian JS, Bach FH (1990) Transplantation of discordant xenografts: a review of progress. Immunology today 11: 450–57CrossRefGoogle Scholar
  8. 8.
    Ricordi C, Tzakis AG, Rybka WB, Fontes P, Ball ED, Trucco M, Kocova M, Triulzi D, McMichael J, Dozle H, Gupta P, Fung JJ, Starzl TE (1994) Xenotransplantation of hematopietic cells resistent to HIV as a potential treatment for patients with AIDS. Transplant Proc 26: 1302–1303PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1995

Authors and Affiliations

  • S. Panzer
    • 1
  1. 1.Klinische Abteilung für BlutgruppenserologieUniversität WienWienÖsterreich

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