Skip to main content
SpringerLink
Log in

Neurologische Komplikationen nach Herztransplantation

  • Chapter
Transplantation

Part of the book series: Intensivmedizinisches Seminar ((INTENSIVM.SEM.,volume 8))

  • 52 Accesses

Zusammenfassung

Neurologische Folgekrankheiten sind schwerwiegende Komplikationen der Transplantationsmedizin. Die vorliegende Übersicht beschäftigt sich mit häufigen und intensivmedizinisch relevanten neurologischen Problemen der Herztransplantation (HTX); einerseits mit cerebralen Komplikationen der immunsuppressiven und medikamentösen Therapie, insbesondere des Cyclosporin A, andererseits mit Folgen des cardiopulmonalen Bypass (CPB) und des zunehmend als Bridging-to-transplantation eingesetzten mechanischen Ventrikelassist und -ersatz. Kenntnis der potentiellen neurologischen Komplikationen kombiniert mit einer pathophysiologisch und funktionell orientierten Diagnostik ist in der Behandlung dieser Patienten erforderlich.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.95
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Adair JC, Woodley SL, O’Cormell JB, Call GK, Baringer JR (1991) Aseptic meningitis following cardiac transplantation. Neurology 41: 249–252

    PubMed  CAS  Google Scholar 

  2. Anstadt MP, Stonnington MJ, Tedder M, et al (1991) Pulsatile reperfusion after cardiac arrest improves neurological outcome. Ann Surg 214: 478–490

    Article  PubMed  CAS  Google Scholar 

  3. Bolton CF (1994) The polyneuropathy of critical illness. J Int Care Med 9: 132–138

    Google Scholar 

  4. Burcar PJ, Norenberg MD, Yarnell PR (1977) Hyponatremia and central pontine myelinolysis. Neurology 27: 223

    PubMed  CAS  Google Scholar 

  5. Carella F, Travaini G, Contri P, Guzzetti S, Botta M, Pieri E, Mangoni A (1988) Cerebral complications of coronary bypass surgery. A prospective study. Acta Neurol Scand 77: 158–163

    Google Scholar 

  6. Cooper DK, Novitzky D, Davis L, Huff JE, Parker D, Schlesinger R, Sholer C, Zuhdi N (1989) Does central nervous system toxicity occur in transplant patients with hypocholesterolemia receiving cyclosporine? J Heart Transplant 8: 221–214

    PubMed  CAS  Google Scholar 

  7. Deverall PB, Padayachee TS, Parsons S, Theobold R, Battistessa SA (1988) Ultrasound detection of micro-emboli in the middle cerebral artery during cardiopulmonary bypass surgery. Eur J Cardiothorac Surg 2: 256–260

    Article  PubMed  CAS  Google Scholar 

  8. Flomenbaum MA, Jarcho JA, Schoen FJ (1991) Progressive multifocal leukencephalopathy fifty-seven months after heart transplantation. J Heart Lung Transplant 10: 888–893

    PubMed  CAS  Google Scholar 

  9. Gilman S (1990) Neurological complications of open heart surgery [editorial]. Ann Neurol 28: 475–476

    Article  PubMed  CAS  Google Scholar 

  10. Grimm G, Madl Ch, Oder W, et al (1991) Evoked potentials in severe herpes simplex encephalitis. Intensive Care Med 17: 94–97

    Article  PubMed  CAS  Google Scholar 

  11. De Groen PC, Aksamit AJ, Rakela J, Krom RAF (1988) Cyclosporine-associated central nervous system toxicity. N Engl J Med 318: 798

    Google Scholar 

  12. Harris DNF, Bailey SM, Smith PLC, Taylor KM, Oatridge A, Bydder GM (1994) Brain swelling in first hour after cardiac surgery. Lancet 342: 586–587

    Article  Google Scholar 

  13. Heikkinen L (1985) Clinically significant neurological disorders following open heart surgery. Thorac Cardiovasc Surg 33: 201–206

    Article  PubMed  CAS  Google Scholar 

  14. Hoefnagels WAJ, Gerritsen EJA, Brouwer OF, Souverijn JHM (1988) Cyclosporin encephalopathy induced by the drug’s solvent (letter). Lancet 1988: 901

    Article  Google Scholar 

  15. Hotson JR, Pedley TA (1976) The neurological complications of cardiac transplantation. Brain 99: 673–694

    Article  PubMed  CAS  Google Scholar 

  16. Lick S, Copeland JG, Smith RG, et al (1993) Use of the symbion biventricular assist device in bridging to transplantation. Ann Thorac Surg 55: 283–271

    Article  PubMed  CAS  Google Scholar 

  17. Loire R, Tabib A, Bastien O (1993) Fatal aspergillosis after cardiac transplantation. About 26 cases. Ann Pathol 13: 157–163

    PubMed  CAS  Google Scholar 

  18. Madl C, Grimm G, Kramer L, et al (1993) Early prediction of individual outcome following cardiopulmonary resuscitation. Lancet 341: 855–858

    Article  PubMed  CAS  Google Scholar 

  19. McManus RP, O’Hair DP, Schweiger J, Beitzinger J, Siegel R (1992) Cyclosporine-associated central neurotoxicity after heart transplantation. Ann Thorac Surg 53: 326–327

    Article  PubMed  CAS  Google Scholar 

  20. Montero CG, Martinez AJ (1986) Neuropathology of heart transplantation: 23 cases. Neurology 36: 1149–1157

    PubMed  CAS  Google Scholar 

  21. Moody DM, Bell MA, Challa VR, Johnston WE, Prough DS (1990) Brain microemboli during cardiac surgery or aortography. Ann Neurol 28: 477–486

    Article  PubMed  CAS  Google Scholar 

  22. Nevin M, Colchester AC, Adams S, Pepper JR (1987) Evidence for involvement of hypocapnia and hypoperfusion in aetiology of neurological deficit after cardiopulmonary bypass. Lancet ii: 1493–1495

    Google Scholar 

  23. Nuver MR (1988) Use of somatosensory evoked potentials for intraoperative monitoring of cerebral and spinal cord function. Neurol Clin 4: 881–897

    Google Scholar 

  24. Pavie A, Muneretto C, Aupart M, et al (1991) Prognostic indices of survival in patients supported with temporary devices ( TAH, Vad). Int J Artif Org 14: 280–285

    CAS  Google Scholar 

  25. Sander KM, Stern TA, O’Gara PT, et al (1992) Medical and neuropsychiatric complications associated with use of the intraaortic balloon pump. J Int Care Med 7: 154–164

    Google Scholar 

  26. Sanderson JM, Wright G, Sims FW (1972) Brain damage in dogs immediately following pulsatile and non-pulsatile blood flows in extracorporeal circulation. Thorax 27: 275–286

    Article  PubMed  CAS  Google Scholar 

  27. Sila CA (1989) Spectrum of neurologic events following cardiac transplantation. Stroke 20: 1586–1589

    Article  PubMed  CAS  Google Scholar 

  28. Smith PL (1988) The cerebral complications of coronary artery bypass surgery. Ann R Coll Surg Engl 70: 212–216

    PubMed  CAS  Google Scholar 

  29. Stephan H, Weyland A, Kazmaier S, Henze T, Menck S, Sonntag H (1992) Acid-base management during hypothermic cardiopulmonary bypass does not affect cerebral metabolism but does affect blood flow and neurological outcome. Br J Anaesth 69: 51–57

    Article  PubMed  CAS  Google Scholar 

  30. Thompson CB, June CH, Sullivan KM, Thomas ED (1988) Association between cyclosporin neurotoxicity and hypomagnesemia. Lancet ii: 1116–1120

    Google Scholar 

  31. Toung TJ, Bunke FJ, Grayson RF, et al (1992) Effects of cyclosporine on cerebral blood flow and metabolism in dogs. Transplantation 53: 1082–1088

    Article  PubMed  CAS  Google Scholar 

  32. Vazquez de Prada J A, Martin Duran R, Garcia Monco C, Calvo JR, Olalla JJ, Gonzalez Vilchez F, Gutierrez JA (1990) Cyclosporine neurotoxicity in heart transplantation. J Heart Transplant 9: 581–583

    Google Scholar 

  33. Wagner WR, Johnson PC, Kormos RL, Griffith BP (1993) Evaluation of bio-prosthetic valve-associated thrombus in ventricular assist device patients. Circulation 88: 2023–2029

    PubMed  CAS  Google Scholar 

  34. Witt NJ, Zochodne DW, Bolton CF, et al (1991) Peripheral nerve function in sepsis and multiorgan failure. Chest 99: 176–194

    Article  PubMed  CAS  Google Scholar 

  35. Wong BI, McLean RF, Naylor CD, (1992) Central-nervous-system dysfunction after warm or hypothermic cardiopulmonary bypass. Lancet: 1383–1384

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Intensivstation, Universitätsklinik für Innere Medizin IV, AKH, Wien, Österreich

    Dr. L. Kramer, C. Madl, C. Zauner & K. Lenz

  2. Notfallaufnahme, AKH, Wien, Österreich

    W. Hödl

  3. Klinische Abteilung für Herz-Thoraxchirurgie, Universitätsklinik für Chirurgie, AKH, Wien, Österreich

    G. Laufer

Authors
  1. Dr. L. Kramer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Madl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Hödl
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Zauner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Laufer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Lenz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Steyr, Austria

    Gunther Kleinberger

  2. Wien, Austria

    Kurt Lenz  & F. Stockenhuber  & 

  3. Basel, Switzerland

    Rudolf Ritz

  4. Hildesheim, Deutschland

    Hans-Peter Schuster

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag/Wien

About this chapter

Cite this chapter

Kramer, L., Madl, C., Hödl, W., Zauner, C., Laufer, G., Lenz, K. (1995). Neurologische Komplikationen nach Herztransplantation. In: Kleinberger, G., Lenz, K., Ritz, R., Schuster, HP., Stockenhuber, F. (eds) Transplantation. Intensivmedizinisches Seminar, vol 8. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7678-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-7678-8_10

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82648-5

  • Online ISBN: 978-3-7091-7678-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation