Use of recombinant human erythropoietin in the treatment of myelodysplastic syndromes

  • Mario Cazzola


Myelodysplastic syndromes (MDSs) are clonal proliferations of multipotent bone marrow stem cells which retain their capacity to differentiate but do so in an inefficient manner, so that mature blood cells are variably reduced (Gallagher et al. 1997; Aul et al. 1998; Vallespí et al. 1998). With time there is a progressive impairment in the capacity of stem cells to differentiate and an increasingly high risk of evolution to overt acute myeloid leukemia. Although the clinical course of these disorders is highly variable from patient to patient, the International Prognostic Scoring System (Greenberg et al. 1997) provides an improved method for evaluating prognosis in individual MDS patients (Sanz et al. 1998).


Myelodysplastic Syndrome International Prognostic Scoring System Serum Erythropoietin Erythroid Response Mature Blood Cell 
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© Springer-Verlag/Wien 2002

Authors and Affiliations

  1. 1.Department of HematologyUniversity of Pavia School of Medicine, IRCCS Policlinico S. MatteoPaviaItaly

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