Biology of erythropoietin

  • Catherine Lacombe
  • P. Mayeux


Patients undergoing chemotherapy for cancer are at risk of developing anemia, and recombinant human erythropoietin (Epo) is an alternative to replace transfusions of allogenic red blood cells in this setting. This article will review the regulation of the Epo gene, the structure of the Epo receptor (EpoR) and the Epo-induced intracellular signaling events. Finally, we will describe other compounds and mechanisms which mimic Epo action, thereby also leading to intracellular signalling albeit with a decreased efficiency when compared to Epo.


Erythropoietin Receptor Human Erythropoietin Gene EpoR Molecule Thropoietin Receptor 
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Copyright information

© Springer-Verlag/Wien 2002

Authors and Affiliations

  1. 1.Institut National de la Santé et de la Recherche Médicale, ICGMUniversité René DescartesFrance
  2. 2.Service d’Hématologie, AP-HPHôpital CochinParisFrance

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