Zusammenfassung
Unter Wechselwirkungen von Arzneimitteln werden erwünschte und unerwünschte Wirkungen verstanden, die nur bei gleichzeitiger Gabe zweier oder mehrerer Arzneimittel auftreten. Bisweilen wird der Begriff Arzneimittelinteraktion allein auf die unerwünschten Wirkungen begrenzt, die aus Kombinationen resultieren. Allgemein und insbesondere in der Psychopharmakotherapie sind jedoch erwünschte und unerwünschte klinische Wirkungen nicht absolut definierbar. So können zum Beispiel sedierende Pharmakowirkungen je nach therapeutischer Zielsetzung erwünscht oder unerwünscht sein. Deshalb erscheint es uns sinnvoll, Wechselwirkungen unter dem Aspekt der Psychopharmakotherapie etwas weiter zu definieren. Unter Arzneimittelinteraktionen sollen hier alle klinisch bedeutsamen Wirkungen verstanden werden, die sich aus einer Kombinationsbehandlung mit Psychopharmaka ergeben, die entweder auf eine verbesserte therapeutische Wirkung oder auf eine Verminderung von unerwünschten Wirkungen abzielt. Wesentlich für die Begriffsdefinition ist, daß unter Interaktionen nicht nur Verstärkungen oder Abschwächungen des ursprünglich oder zusätzlich verabreichten Medikaments verstanden werden, sondern auch das Auftreten von neuen Wirkungen.
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Klein, H.E., Rüther, E. (1983). Klinisch bedeutsame Wechselwirkungen der Psychopharmaka. In: Langer, G., Heimann, H. (eds) Psychopharmaka. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7645-0_21
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