Brain Edema pp 128-151 | Cite as

Sequence of Pathological Changes in Brain Edema

  • Irwin Feigin


This paper will describe observations on the characteristics, course and sequelae of cerebral edema in man, and will attempt to draw some inferences from these observations as to the nature of the process and the mechanisms involved. In general, these observations are in accord with many earlier reports (Greenfield, Perret and Kernohan; Scheinker) and the interpretations drawn are classical, including that which considers cerebral edema to be an increment of fluid in an extracellular space, as is true in other organs.


White Matter Gray Matter Cerebral Edema Myelinated Fiber Deep White Matter 
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  1. Adachi, M. and I. Feigin: Cerebral edema and the water content of normal white matter, J.Neurol. Neurosurg. Psychiat., 29, 446 (1966).CrossRefGoogle Scholar
  2. Aleu, F. P., R. Katzman and R. D. Terry: Fine structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication, J. Neuropath. Exper. Neurol., 344 (1963a).Google Scholar
  3. Aleu, F. P., R. Katzman and R. D. Terry: Fine structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication, Ibid., 403–413 (1963 b).Google Scholar
  4. Bahr, G. F., G. Bloom and V. Friberg: Volume changes of tissues in physiological fluids during fixation in osmium tetroxide or formaldehyde and during subsequent treatment, Exper. Cell Res., 12, 342–355 (1957).CrossRefGoogle Scholar
  5. Blackwood, W.: in Greenfield’s Neuropathology, 2nd ed., Baltimore: Williams & Wilkins Co., 126 (1963).Google Scholar
  6. Binswanger, O.: Die Abgrenzung der allgemeinen progressiven Paralyse. Berl. Klin. Wschr.. 31. 1103–1105, 1137–1139, 1180–1186 (1894).Google Scholar
  7. Byrom, F. B.: The pathogenesis of hypertensive encephalopathy and its relation to the malignant phase of hypertension: Experimental evidence from the hypertensive rat. Lancet. 2. 201–211 (1954).CrossRefGoogle Scholar
  8. Feigin, I. and N. Popoff: Neuropathological observations on cerebral edema: The acute phase, Arch. Neurol.. 6, 151–160 (1962).Google Scholar
  9. Feigin, I. and N. Popoff: Neuropathological changes late in cerebral edema: The relationship to trauma, hypertensive disease and Binswangens encephalopathy, J. Neuropath. Exper. Neurol., 22, 500–511 (1963).CrossRefGoogle Scholar
  10. Flatau, E.: Beitrag zur technischen Bearbeitung des Centralnerven systems, Anat. Anzeiger, 13, 323–329 (1897).Google Scholar
  11. Folchi-Pi, J. and F. N. LeBaron: Chemical composition of the mammalian nervous system, in: Metabolism of the nervous system (ed. by D. Richter). New York: Pergamon Press, 68 (1957).Google Scholar
  12. Gerschenfeld, H. M., F. Wald, J. A. Zadunaisky and E. P. D. De Robertis: Function of astroglia in the water-ion metabolism of the central nervous system, Neurology, 9, 412–425 (1959).PubMedGoogle Scholar
  13. Gonatas, N. K., H. M. Zimmerman,and S. Levine: Ultrastructure of inflammation with edema in the rat brain, Am. J. Path.. 42, 455–469 (1963).PubMedGoogle Scholar
  14. Greenfield, J. G.: The histology of cerebral edema associated with intracranial tumors (with special reference to changes in the nerve fibers of the centrum ovale). Brain, 62, 129–152 (1939).CrossRefGoogle Scholar
  15. Gross, W. and H. Lohaus: Untersuchungen über die Wirkung von Härtungsflüssigkeiten auf tierische Gewebe, Ztchr. f. Wiss. Mi-kroskop., 49, 168–190 (1932).Google Scholar
  16. Herzog, I., W. A. Levy and L. C. Scheinberg: Biochemical and mor-phologic studies of cerebral edema associated with intracerebral tumors in rabbits, J. Neuropath. Exper. Neurol., 24, 244–255 (1965).CrossRefGoogle Scholar
  17. Hirano, A., H. M. Zimmerman and S. Levine: The fine structure of cerebral fluid accumulation. III. Extracellular spread of cryp- tococcal polysaccharides in the acute stage, Amer. J. Path.. 45, 1–19 (1964).PubMedGoogle Scholar
  18. Hrdlicka, A.: Brains and brain preservatives. Part I. Physical changes in human and other brains collected under different conditions and preserved in various formalin preparations, Proc. U. S. Nat’l. Museum. 30, 245-276 (1906).Google Scholar
  19. Lagerlof, H. and T. Torgersrund: Zur Kenntnis der Gewichts und Volumen Veränderungen bei Formalin Fixation von Gehirngewebe und der Einwirkung von NaCl-Zusatz darauf, J. f. Psychol, u. Neurol., 46, 178–188 (1934).Google Scholar
  20. Long, D. M. and J. F. Hartmann: The ultrastructure of human cerebral edema, J. Neuropath. Exper. Neurol., 24, 150–151 (1965).Google Scholar
  21. Luse, S. A. and B. Harris: Electron microscopy of the brain in ex-perimental edema, J. Neurosurg., 17, 439–446 (1960).Google Scholar
  22. Mackay, R. P.: Year Book of Neurology, Psychiatry and Neurosurgery, 1962–1963, Chicago Year Book Publishing Co., p. 7.Google Scholar
  23. Naoumenko, J. and I. Feigin: A modification for paraffin sections of the Cajal gold-sublimate stain for astrocytes, J. Neuropath. Exper. Neurol., 20, 602–604 (1961).CrossRefGoogle Scholar
  24. Naoumenko, J. and A modification for paraffin section of silver carbonate impregnation for microglia, Acta Neuropath., 2, 402–406 (1963).Google Scholar
  25. Perret, G. E. and J. W. Kernohan: Histopathologic changes of the brain caused by intracranial tumors (so-called edema or swelling of the brain), J. Neuropath. Exper. Neurol., 2, 341–352 (1943).CrossRefGoogle Scholar
  26. Raimondi, A. J., J. P. Evans and S. Mullan: Studies of cerebral edema, III, Alterations in the white matter: An electron microscopic study using Ferritin as a labeling compound, Acta Neuropath., 2, 177–197 (1962).Google Scholar
  27. Scheinker, I. M.: Cerebral swelling: Histopathology, classification and clinical significance of brain edema, J. Neurosurg., 4, 255–275 (1947).PubMedCrossRefGoogle Scholar
  28. Stewart-Wallace, A. M.: A biochemical study of cerebral tissue and the changes in cerebral oedema, Brain. 62, 426–438 (1939).CrossRefGoogle Scholar
  29. Taylor, J. M., W. A. Levy, I. Herzog and L. C. Scheinberg: Prevention of experimental cerebral edema by cortico-steroids. Biochemical and ultrastructural studies, Neurology (Minn.), 15, 667–674 (1965).Google Scholar
  30. Torack, R. M., R. D. Terry and H. M. Zimmerman: The fine structure of cerebral fluid accumulation: I. Swelling secondary to cold injury, Amer. J. Path., 35, 1135–1147 (1959).Google Scholar
  31. Zimmerman, H. M.: Some contributions of electron microscopy to problems in pathology, The 24th Middleton Goldsmith Lecture, Bull. N. Y. Acad. Med.. 40. 831–862 (1964).Google Scholar
  32. Zülch, K. J.: Hirnödem und Hirnschwellung, Virchow Archiv Path. Anat., 310, 1–58 (1943).Google Scholar

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© Springer-Verlag New York Inc. 1967

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  • Irwin Feigin

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