Effects of X-Irradiation on Guinea Pig Brain
Our previous studies have shown that X-irradiation of guinea pig brain results in an initials increase of pinocytosis in capillary endothelium and brain edema during the first hours and days (Franke & Lierse, 1995). The purpose of this study was to ascertain whether this edema persists and/or other changes develop in the capillaries in the next six months. Klatzo, et al. (1961, 1962), Miquel, et al. (1963), have demonstrated that the permeability of the rat brain capillaries increases and that at the same time the metabolism of carbohydrates is disturbed. We found accumulation of glycogen as well as mucopolysaccharides in the brain of guinea pigs.
KeywordsBrain Edema Capillary Endothelium Adjacent Endothelial Cell Lead Hydroxide Brain Glycogen
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- Brownson, R. H., D. B. Suter, J. L. Oliver and D. A. Diller: Acute brain damage induced by x-irradiation with special reference to rate and recovery rates, Neurology (Minneapolis), 13, 1011–1020 (1963).Google Scholar
- Klatzo, I., J. Miquel, W. Haymaker, C. Tobias and L. S. Wolfe: Observations on appearance of histochemically-demonstrable glycogen in the rat brain as effect of alpha-particle irradiation, Proc. Sympos. Effects Ioniz. Rad, on the Nerv. Syst., Vienna: Internat. Atomic Energy Agency, 285–296 (1962).Google Scholar