Brain Edema pp 639-644 | Cite as

Effects of X-Irradiation on Guinea Pig Brain

An Electronmicroscopical and Histochemical Study
  • Werner Lierse
  • Herbert D. Franke


Our previous studies have shown that X-irradiation of guinea pig brain results in an initials increase of pinocytosis in capillary endothelium and brain edema during the first hours and days (Franke & Lierse, 1995). The purpose of this study was to ascertain whether this edema persists and/or other changes develop in the capillaries in the next six months. Klatzo, et al. (1961, 1962), Miquel, et al. (1963), have demonstrated that the permeability of the rat brain capillaries increases and that at the same time the metabolism of carbohydrates is disturbed. We found accumulation of glycogen as well as mucopolysaccharides in the brain of guinea pigs.


Brain Edema Capillary Endothelium Adjacent Endothelial Cell Lead Hydroxide Brain Glycogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brownson, R. H., D. B. Suter, J. L. Oliver and D. A. Diller: Acute brain damage induced by x-irradiation with special reference to rate and recovery rates, Neurology (Minneapolis), 13, 1011–1020 (1963).Google Scholar
  2. Franke, H. and W. Lierser: Elekronenmikroskopische Untersuchungen über Hirn Veränderungen des Meerschweinchens nach Röntgenbestrahlung, Fortschr. Röntgenstr., 102, 78–87 (1965).CrossRefGoogle Scholar
  3. Klatzo, I., J. Miquel, W. Haymaker, C. Tobias and L. S. Wolfe: Observations on appearance of histochemically-demonstrable glycogen in the rat brain as effect of alpha-particle irradiation, Proc. Sympos. Effects Ioniz. Rad, on the Nerv. Syst., Vienna: Internat. Atomic Energy Agency, 285–296 (1962).Google Scholar
  4. Klatzo, I., C. Tobias and W. Haymaker: Effects of alpha particle radiation on the rat brain, including vascular permeability and glycogen studies, J. Neuropath, exper. Neurol., 20, 459–483 (1961).CrossRefGoogle Scholar
  5. Maxwell, D. S. and L. Kruger: The fine structure of astrocytes in the cerebral cortex and their response to focal injury produced by heavy ionizing radiation, J. cell Biol., 25, (May), 141–157 (1965).PubMedCrossRefGoogle Scholar
  6. Miquel, J., I. Klatzo, D. B. Menzel and W. Haymaker: Glycogen changes in x-irradiated rat brain, Acta neuropath., 2, 482–490 (1963).CrossRefGoogle Scholar
  7. Wolfe, L. S., I. Klatzo, J. Miquel, C. Tobias and W. Haymaker: Effect of alpha-particle irradiation on brain glycogen in the rat, J. Neurochem., 9, 213–218 (1962).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1967

Authors and Affiliations

  • Werner Lierse
  • Herbert D. Franke

There are no affiliations available

Personalised recommendations