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Brain Edema pp 615-631 | Cite as

Brain Edema Induced by Particle and Ultraviolet Radiation

  • Jaime Miquel
  • Webb Haymaker

Abstract

Interest in the study of experimental brain edema has stimulated the development of a variety of edema-producing techniques. Among others, extradurally inflated balloons (Ishii, et al.), and freezing of the cortex (Bakay & Haque; Clasen, et al., 1957, 1962; Klatzo, et al., 1958; Pappius & Gulatti), have been used in an effort to elucidate the pathogenesis of traumatic brain edema. Although, since Rachmanov’s observations in 1926 radiation has been known to produce brain permeability disturbances, and although an edematous process following irradiation has been demonstrated, there has been no study directed at utilizing radiation-induced injury as a “model” for the study of pathogenesis of brain edema or of the effectiveness of therapy. This is rather surprising since radiation offers unsurpassed versatility in the production of brain lesions in any area or depth desired. Brain edema reproducible with great uniformity should be easily achieved by the simple expedient of exposing the brain of a series of animals to identical radiation dosage. These considerations prompted us to undertake the present study on rat and cat brain edema induced by particle and ultraviolet (UV) radiation.

Keywords

White Matter Brain Edema Alpha Particle Evans Blue Surface Dose 
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References

  1. Bakay, L. and I. U. Haque: Morphological and chemical studies in cerebral edema. I. Cold induced edema, J. Neuropath, exp. Neurol., 23, 393–418 (1964).CrossRefGoogle Scholar
  2. Clasen, R. A., P. M. Cooke, S. Pandolfi, D. Boyd and A. J. Raimondi: Experimental cerebral edema produced by focal freezing. I. An anatomic study utilizing vital dye techniques, Ibid., 21, 579–596 (1962).Google Scholar
  3. Clasen, R. A., R. R. Prouty, W. G. Gingham, F. A. Martin, and G. M. Hass: Treatment of experimental cerebral edema with intravenous hypertonic glucose, albumin and dextran, Surg. Gyn. Obst., 104, 591 - 606 (1957).Google Scholar
  4. Clemente, C. D. and E. A. Hoist: Pathological changes in the blood brain barrier, neuroglia and EEG induced by X-irradiation of the heads of monkeys, Proc. 19th Internat. Physiol. Congr. Montreal, pp. 273–274 (1953).Google Scholar
  5. Clemente, C. D. and E. A. Hoists: Pathological changes in neurons, neuroglia, and blood-brain barrier induced by X-irradiation of heads of monkeys, A.M.A. Arch. Neurol. & Psychiat., 71, 66–79 (1954).Google Scholar
  6. Daniels, F., D. Brophy and W. C. Lobitz: Histochemical responses of human skin following ultraviolet irradiation, J. Invest. Dermatol., 37, 351–357 (1961).PubMedGoogle Scholar
  7. Friede, R.: Die Bedeutung der Glia fur den zentralen Kohlenhydratstoffwechsel, Zbl. allg. path. Anat., 92, 65–74 (1954).Google Scholar
  8. Greenfield, J. G.: The histology of cerebral edema associated with intracranial tumours (with special reference to changes in the nerve fibers of the centrum ovale), Brain, 62, 129 - 151 (1939).CrossRefGoogle Scholar
  9. Hager, H., W. Hirschberger and A. Breit: Electron microscope observations on the X-irradiated central nervous system in the Syrian hamster. In: Response of the Nervous System to Ionizing Radiation (ed. by T. J. Haley and R. S. Snider), New York: Academic Press, 261–275 (1962).Google Scholar
  10. Ishii, S., R. Hayner, W. A. Kelly, and J. P. Evans: Studies of cerebral swelling. II. Experimental cerebral swelling produced by supratentorial extradural compression, J. Neurosurg., 16, 152–166 (1959).PubMedCrossRefGoogle Scholar
  11. Janssen, P., I. Klatzo, J. Miquel, T. Brustad, A. Behar, W. Haymaker, J. Lyman, J. Henry and C. Tobias: Pathologic changes in the brain from exposure to alpha particles from a 60-inch cyclotron. In: Response of the Nervous System to Ionizing Radiation (ed. by T. J. Haley and R. S. Snider), New York: Academic Press, 383–409 (1962).Google Scholar
  12. Klatzo, I., J. Miquel, C. Tobias,and W. Haymaker: Effects of alpha particle radiation on the rat brain including vascular permeability and glycogen studies, J. Neuropath, exp. Neurol., 20, 459 - 483 (1961).CrossRefGoogle Scholar
  13. Klatzo, I., A. Piraux and E. J. Laskowsky: The relationship between edema, blood-brain barrier and tissue elements in a local brain injury, Ibid., 17, 548–564 (1958).Google Scholar
  14. Larsson, B.: Blood vessel changes following local irradiation of the brain with high-energy protons, Acta Soc. med, upsal., 65, 61–71 (1960).Google Scholar
  15. Miquel, J.: Unpublished observation.Google Scholar
  16. Miquel, J., and W. Haymaker: Astroglial reactions to ionizing radiation, Progr. in Brain Res, 15, 87–114 (1965).Google Scholar
  17. Miquel, J., I. Klatzo, D. B. Menzel,and W. Haymaker: Glycogen changes in X-irradiated brain, Acta neuropath., 2, 482–490 (1963).CrossRefGoogle Scholar
  18. Mogilnitzsky, B. and L. D. Podljalschuk: Röntgenstrahlen und sogen, “hämatoenzephalische Barrière, Fortschr.” Röntgenstr., 41, 66–75 (1930).Google Scholar
  19. Pappius, H. M. and D. R. Gulati: Water and electrolyte content of cerebral tissues in experimentally induced edema, Acta neuropath., 2, 451–460 (1963).CrossRefGoogle Scholar
  20. Rachmanov, A.: Zur Frage über die Wirkung der Röntgenstrahlen auf des Zentralnervensystem, Strahlentherapie, 23, 318–329 (1926).Google Scholar
  21. Schümmelfeder, N., K. J. Ebschner, H. D. Bergeder, and E. Krogh: Strahlennekrose am Kleinhirn nach einzeitiger, hochdosierter Röntgenbestrahlung, Virchows Arch, path. Anat., 334, 32–55 (1961).Google Scholar
  22. Van Dyke, D. C., P. Janssen,and C. A. Tobias: Fluorescein as a sensitive, semiquantitative indicator of injury following alpha particle irradiation of the brain. In: Response of the Nervous Sys-tem to Ionizing Radiation, (ed. by T. J. Haley and R. S. Snider) New York: Academic Press, 369–382 (1962).Google Scholar

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© Springer-Verlag New York Inc. 1967

Authors and Affiliations

  • Jaime Miquel
  • Webb Haymaker

There are no affiliations available

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