Skip to main content

Brain Edema

Some Clinical and Experimental Correlations

  • Conference paper
Brain Edema

Abstract

When the neurological surgeon has occasion to expose the brain in the presence of increased intracranial pressure, he indeed opens a Pandora’s box. Cushing in his Cameron Lectures of 1925 succinctly summarized his understanding of the problems of cerebrospinal fluid circulation as he and his contemporaries faced them (1). In the intervening forty years, particularly with the advent of more elaborate physiological recording techniques, with the development of experimental models simulating clinical conditions, and with the introduction of the electron microscope, a fuller, though even yet an incomplete, understanding of pressure problems has evolved.

Aided in part by a grant from U. S. Public Health Service, No. NB 04686-02, and in part by the Junior Auxiliary of the University of Chicago Cancer Research Foundation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cushing, H.: The third circulation and its channels: Studies in intracranial physiology, London: Oxford University Press, pp. 1–51.

    Google Scholar 

  2. Ryder, H. W., F. F. Espey, F. D. Kimball, E. J. Penka, A. Rosenauer,B.Podolsky and J. P.Evans: The mechanism of the change in cerebrospinal fluid pressure following an induced change in the volume of the fluid space, J. Lab, and Clin. Med., 41, 428–435 (1953).

    CAS  Google Scholar 

  3. Evans, J. P., F. F. Espey, F. D. Kristoff, F. D. Kimball and H. W. Ryder: Experimental and clinical observation on rising intracranial pressure, Arch. Surg., 63, 107–114 (1951).

    CAS  Google Scholar 

  4. Weinstein, J. D., T. W. Langfitt and N. F. Kassel: Vasopressor response to increased intracranial pressure, Neurology, 14, 1118–1131 (1964).

    PubMed  CAS  Google Scholar 

  5. Lundberg, N., H. Troop and H. Lorin: Continuous recording of the ventricular fluid pressure in patients with severe acute traumatic brain injury, J. of Neurosurg., 22, 581–591 (1965).

    Article  CAS  Google Scholar 

  6. Langfitt, T. W.: Possible mechanisms of action of hypertonic urea in reducing intracranial pressure, Neurology, 11, 196–209, (1961).

    PubMed  CAS  Google Scholar 

  7. Ishii, S., R. Hayner, W. A. Kelly and J. P. Evans: Studies of cerebral swelling, II: Experimental cerebral swelling produced by supra-tentorial extradural compression, J. Neurosurg., 16, 152–166 (1959).

    Article  PubMed  CAS  Google Scholar 

  8. and E. Tani: Electron microscope studies in blood-brain barrier in cerebral swelling, Acta Neuropath. (Berlin), 1, 474–488 (1962).

    Google Scholar 

  9. Tani, E. and J. P. Evans: Electron microscope studies of cerebral swelling, I: Studies on the permeability of brain capillaries using ferritin molecules as tracers, Acta Neuropath., 4, 507–526 (1965).

    Article  Google Scholar 

  10. Tani, E. and J. P. Evans: Electron microscope studies of cerebral swelling, II: Alterations of myelinated nerve fibers, Ibid., 604–623.

    Google Scholar 

  11. Tani, E. and J. P. Evans: Electron microscope studies of cerebral swelling, III: Alterations in the neuroglia and the blood vessels of the white matter, Ibid., 624–639.

    Google Scholar 

  12. Ziilch, K.: Proc. Symp. on Brain Edema (ed. by I. Klatzo and F. Seiteiberger ). Springer-Verlag New York (1967).

    Google Scholar 

  13. Schroeder, J. M. and W. Wechsler: Ödem und Nekrose in der grauen und weissen Substanz beim experimentällen Hirntrauma (Licht-und elekronen microskopische Untersuchungen), Acta Neuropath., 5, 82–111 (1965).

    Article  Google Scholar 

  14. Langfitt, T. W., J. D. Weinstein and N. F. Kassel: Cerebral vasomotor paralysis produced by intracranial hypertension, Transact, of Am. Neurol. Assoc., pp. 214–215 (1964).

    Google Scholar 

  15. Wolff, H. G. and H. S. Forbes: The cerebral circulation, V: Observations of the pial circulation during changes in intracranial pressure, Arch. Neurol. Psychiat., 20, 1035–1047 (1928).

    Google Scholar 

  16. Evans, J. P. and I. M. Scheinker: Histologic studies of the brain following head trauma. VI: Posttraumatic central nervvous system changes interpreted in terms of circulatory disturbances, Research Publ., J. Nerv, and Ment. Diseases, 24, 254–273 (1945).

    Google Scholar 

  17. Reichard, M.: Das Hirnödem (appendix section Die Hirnschwellung), in the series: “Handbuch der Speziellen pathologischen Anatomie und Histologie,” Vol. 13, Part 1B, p. 1229. Berlin, Göttingen, Heidelberg: Springer-Verlag (1957).

    Google Scholar 

  18. Lebeau, J.: L’oedeme aigu du cerveau par lesiones experimentales du tronc cerebral: Ses rapports avec Phypertension arterielle, Rev. Canadienne de Biol., 7, 254–293 (1948).

    CAS  Google Scholar 

  19. Evans, J. P. and F. F. Espey: Unpublished observations from the Laboratory of Physiology, Yale University (1948).

    Google Scholar 

  20. Johnson, R. T. and P. O. Yates: Brain stem hemorrhages in expanding sup r atento rial conditions, Acta Radiológica (Stock-holm), 46, 250–256 (1956).

    Article  CAS  Google Scholar 

  21. Thompson, R. K. and S. Malina: Dynamic axial brain-stem distortion as a mechanism explaining the cardio-respiratory changes in increased intracranial pressure, J. Neurosurg., 16, 664–667 (1959).

    Article  PubMed  CAS  Google Scholar 

  22. Kabat, H., H. W. Magoun and S. W. Ranson: Electrical stimulation of points in the forebrain and midbrain, Arch of Neurol. and Psychiat., 34, 931–955 (1935).

    Google Scholar 

  23. Raimondi, A. J., J. P. Evans and S. Mullan: Studies of cerebral edema, EI: Alterations in the white matter: An electron microscopic study using ferritin as a labelling compound, Acta Neuropath. (Berlin), 2, 177–197 (1962).

    Google Scholar 

  24. Basford, R. E. and D. E. Green: Studies on the terminal electron transport system, XXI: On the properties of a soluable lipoprotein dissociated from succinic dehydrogenase complex, Biochem. Biophys. Acta, 33, 185–194 (1959).

    Article  CAS  Google Scholar 

  25. Basford, R. E.: Studies on the terminal electron transport system, XXII: The lipid composition of coenzyme Q lipoprotein, Ibid., 195–201 (1959).

    Google Scholar 

  26. Schneider, W. C.: Phosphorus compounds in animal tissue: extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid, J. Biol. Chem., 161, 293–303 (1945).

    PubMed  CAS  Google Scholar 

  27. Lowry, O. H. and E. J. Robins: Micro determinations of phospholipids and sphingolipids in brain, Ibid., 220, 661–675 (1956).

    Google Scholar 

  28. Folch, J., M. Lees and G. H. Sloane Stanley: A simple method for the isolation and purification of total lipids from animal tissue, Ibid., 226, 497–509 (1957).

    CAS  Google Scholar 

  29. Dische, Z.: Über charakteristische Farbreaktionen der Milchsäure, des Methylglyoxals und der Kohlehydrate mit Carbazol und Schwefelsäure, Biochem. Zeitschrift., 189, 77–80 (1927).

    CAS  Google Scholar 

  30. Warren, L. J.: The thiobarbituric acid assay of sialic acids, J. Biol. Chem., 234, 1971–1975 (1959).

    PubMed  CAS  Google Scholar 

  31. Mcllwain, H.: Characterization of naturally occurring materials which restore excitability to isolated cerebral tissue, Biochem., J. 78, 24–32 (1961).

    Google Scholar 

  32. Wolf, L. S. and H. Mcllwain: Migration of histones from the nuclei of isolated cerebral tissues kept in cold media, Ibid., 33–40 (1961).

    Google Scholar 

  33. Thompson, C. G. and H. Mcllwain: An attachment of protamine to cerebral tissue, studied in relation to gangliosides, suramin and tissue excitability, Ibid., 79, 342–347 (1961).

    Google Scholar 

  34. Deul, D. H. and H. Mcllwain: Activation and inhibition of adenosine triphosphatase of subcellular particles from the brain, J. Neurochem., 8, 246–256 (1961).

    Article  PubMed  CAS  Google Scholar 

  35. Kennedy, E. P.: Biosynthesis of Phospholipids, Fed. Proc., JL6, 847–853 (1957).

    Google Scholar 

  36. Burton, R. M.: Uridine nucleotides and the metabilism of nerve tissue, in: The Neurochemistry of Nucleotides and Amino Acids (ed. by R. O. Brady and D. B. Tower). New York, London: John Wiley & Sons, Inc., pp. 51–69 (1960).

    Google Scholar 

  37. Elliot, K. A. C.: Measurement of experimentally induced brain swelling and shrinkage, Am. J. Physiol., 157, 122–129 (1949).

    Google Scholar 

  38. Polis, B. D.: Studies on rate controlling factors in oxydative phosphorylation, Regional Neurochemistry, Pergamon Press, pp. 37–48 (1961).

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1967 Springer-Verlag New York Inc.

About this paper

Cite this paper

Ishii, S., Tsuji, H., Ozawa, K., Kondo, Y., Evans, J.P. (1967). Brain Edema. In: Klatzo, I., Seitelberger, F. (eds) Brain Edema. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7545-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-7545-3_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7547-7

  • Online ISBN: 978-3-7091-7545-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics