Brain Edema pp 517-529 | Cite as

Radio-Isotopic Studies in Brain Edema

  • Louis Bakay
Conference paper


The original source of the tissue fluid of the central nervous system, whether normal or edematous, is the blood plasma. Consequently, the exchange of water and solutes between plasma and normal as well as edematous brain and their distribution within the various intracerebral compartments is of considerable importance. Data available in man in terms of molecular tissue morphology and chemistry are too few for the evaluation of the biological forces involved in the production of edema. This, at the present time, is largely limited to experimental edemas. These experimental, and consequently artificial, conditions are sometimes completely analogous with the conditions affecting man. Other experimental situations are probably similar to, but not identical with, their human equivalent. However, at the present stage of our limited knowledge about the pathophysiology of the different types of cerebral edemas, controlled investigations are indispensable. The application of radio-active and non-radioactive tracers to study the rate of exchange of various compounds between plasma and edematous brain places a heavy emphasis on experimental work.


White Matter Cerebral Edema Purify Protein Derivative Cortical Lesion Edematous Tissue 
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© Springer-Verlag New York Inc. 1967

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  • Louis Bakay

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