Abstract
In discussions of brain swelling or brain edema, terms like “tissue hypercapnia” and “tissue pH” are often used. Work in our laboratory has dealt more with relations covered by these terms than with the actual conditions of tissue swelling or edema. However, it is felt that a discussion of some basic principles related to the normal acid-base regulation of brain tissue will be helpful when considering the even more intricate problems of a tissue with disturbed water and electrolyte metabolism.
Supported by contract N62558-4288 between the Office of Naval Research, Department of the U.S. Navy; the University of Lund; and by the Swedish Medical Research Council.
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References
Albaum, H. G., J. Tepperman and O. Bodansky: The in vivo inactivation by cyanide of brain cytochrome oxidase and its effect on glycolysis and on the high energy phosphorus compounds in brain, J. Biol. Chem., 165, 45–51 (1946).
Bourke, R. S., E. S. Greenberg and D. B. Tower: Variation of cerebral cortex fluid spaces in vivo as a function of species brain size, Amer, J. Physiol., 208, 682–692 (1965).
Brzezinski, J., A. Kjallquist and B. Siesjo: Mean carbon dioxide tension in the brain after carbonic ¡anhydrase inhibition, J. Physiol. 188, 13–23 (1967).
Cain, S. M. and A. B. Otis: C02 retention in anesthetized dogs after inhibition of carbonic anhydrase, Proc. Soc. Exp. Biol, and Med, 103, 439–441 (1960).
Cain, S. M. and A. B. Otis: Effect of carbonic anhydrase inhibition on mixed venous C02 tension in anesthetized dogs, J. Appl. Physiol., 15, 390–392 (1960).
Carter, E. T. and R. T. Clark, Jr.: Respiratory effects of carbonic anhydrase inhibition in the trained unanesthetized dog, Ibid., 13, 42–46 (1958).
Conway, E.J. and P. J. Fearon: The acid-labile C02 in mammalian muscle and the pH of the muscle fibre, J. Physiol., 103, 274–289 (1944).
Danielson, I. S., H. I. Chu and A. B. Hastings: The pKí of carbonic acid in concentrated protein solutions and muscle, J. Biol. Chem., 131, 243–257 (1939).
Davson, H. and C. P. Luck: The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of 24Na in these fluids, J. Physiol., 137, 279–293 (1957).
Diemer, K.: Eine verbesserte Modellvorstellung zur Sauerstoffversorgung des Gehirns, Naturwissenschaften, 19, 617–618 (1963).
Giacobini, E.: A cytochemical study of the localisation of carbonic anhydrase in the nervous system, J. Neurochem., 9, 169–177 (1962).
Gleichmann, U., D. H. Ingvar, D. Lubbers, B. K. Siesjö and G. Thews: Tissue pO2 and pCO2 of the cerebral cortex, related to blood gas tensions, Acta Physiol. Scand., 55, 127–138 (1962).
Kety, S. S.: Determinants of tissue oxygen tension, Fed. Proc., 16, 666–670 (1957).
Koch, A. and D. M. Woodbury: Carbonic anhydrase inhibition and brain electrolyte composition, Amer. J. Physiol., 198, 434–440 (1960).
Krogh, A.: The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue, J. Physiol., 52, 409–415 (1918-19).
Kjallquist, Å. and B, K. Siesjö: Increase in the intracellular bicarbonate concentration in the brain after acetazolamide, Acta Physiol. Scand., 68, 255–256 (1966).
Lubbers, D. W.: Capillary pattern and oxygen tension of the cerebral cortex, in: Regional Cerebral Blood Flow (ed. by D. H. Ingvar and N. Lassen, Acta Neurol. Scand., suppl. 14, 92–93 (1965).
Maren, T. H. and B. Robinson: The pharmacology of acetazolamide as related to cerebrospinal fluid and the treatment of hydrocephalus, Bull. Johns Hopkins Hosp., 106, 1–24 (1960).
Mithoefer, J. C.: Inhibition of carbonic anhydrase: its effect on carbon dioxide elimination by the lungs, J. Appl. Physiol., 14, 109–115 (1959).
Mithoefer, J. C. and J. S. Davis: Inhibition of carbonic anhydrase: Effect on tissue gas tensions in the rat, Proc. Soc. Exper. Biol. & Med., 98, 797–801 (1958).
Olsen, N. S. and J. R. Klein: Effect of cyanide on the concentration of lactate and phosphates in brain, J. Biol. Chem., 167, 739–746 (1947).
Oppelt, W. W., C. S. Patlak and D. P. Rail: Effect of certain drugs on cerebrospinal fluid production in the dog, Amer. J. Physiol., 206, 247–250 (1964).
Pappenheimer, J. R., V. Fencl, S. R. Heisey and D. Held: Role of cerebral fluids in control of respiration as studied in unanesthetized goats, Ibid., 208, 436–450 (1965).
Ponton, U.: The CO2-binding capacity of rat brain tissue in vivo, Experientia, 20, 287–288 (1964).
Ponton, U.: Acid-base changes in rat brain tissue during acute respiratory acidosis and baseosis, Acta Physiol. Scand., 68, 152–163 (1966).
Ponton, U. and B. K. Siesjo: Gradients of CO2 tension in the brain, (to be published).
Rail, D. P., W. W. Oppelt and C. S. Patlak: Extracellular space of brain as determined by diffusion of inulin from the ventricular system, Life Sciences, 2, 43–48 (1962).
Roos, A.: Intracellular pH and intracellular buffering power of the cat brain, Amer. J. Physiol., 209, 1233–1246 (1965).
Siesjö, B. K.: The solubility of carbon dioxide in cerebral cortical tissue from the cat at 37.5°C. With a note on the solubility of carbon dioxide in water, 0.16 M NaCl and in cerebrospinal fluid, Acta Physiol. Scand., 55, 325–341 (1962).
Siesjö, B. K.: The bicarbonate/carbonic acid buffer system of the cerebral cortex of the cat, as studied on tissue homogenates. II. The pKí of carbonic acid and the relation between carbon dioxide tension and pH, Acta Neurol. Scand., 38, 121–141 (1962).
Siesjö, B. K. and U. Ponten: Tissue pH — true parameter or misnomer?, Annals-N. Y. Acad. Sci., 133, 78–86 (1966).
Siesjö, B. K. and U. Ponten:: The CO2 buffer capacity of brain tissue and of equivalent systems, Annals N. Y. Acad. Sci., 133, 180–194 (1966).
Siesjö, B. K., U. Ponten, G. Thews: Ein Verfahren zur Bestimmung der CO2-Leitfähigkeit der CO2-Diffusionskoeffizienten und des scheinbaren CO2-Löslichkeitskoeffizienten im Gehirngewebe, Pflüg. Arch., 276, 192–210 (1962).
van Slyke, D. D., J. Sendroy, Jr., A. B. Hastings and J. M. Neill: Studies of gas and electrolyte equilibria in blood. X. The solubility of carbon dioxide at 38°C in water, salt solution, serum and bloody cells, J. Biol. Chem., 78, 765–799 (1928).
Thews, G.: Über die Mathematische Behandlung Physiologischer Diffuzionsprozesse in Zylinderförmigen Objekten, Acta Biotheoretica, 10, 105–137 (1953).
Thews, G.: Die Sauerstoffdiffusion im Gehirn. Ein Beitrag zur Frage der Sauerstoffversorgung der Organe, Pflüg. Arch., 271, 197–226 (1960).
Waddell, W. J. and T. C. Butler: Calculation of intracellular pH from the distribution of 5.5-dimethyl-2.4 oxazolidinedione (DMO). Application to skeletal muscle of the dog, J. Clin. Invest., 38, 720–729 (1959).
Wistrand, P., B. R. Nechay and T. H. Maren: Effects of carbonic anhydrase inhibition on cerebrospinal and intraocular fluids in the dog, Acta Pharmacol Toxicol., 17, 315–336 (1961).
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Siesjö, B.K., Brzeziński, J., Kjällquist, Å., Pontén, U. (1967). Carbon Dioxide and Acid-Base Equilibria in Brain Tissue. In: Klatzo, I., Seitelberger, F. (eds) Brain Edema. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7545-3_29
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DOI: https://doi.org/10.1007/978-3-7091-7545-3_29
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