Brain Edema pp 388-405 | Cite as

Carbon Dioxide and Acid-Base Equilibria in Brain Tissue

  • B. K. Siesjö
  • J. Brzeziński
  • Å. Kjällquist
  • U. Pontén


In discussions of brain swelling or brain edema, terms like “tissue hypercapnia” and “tissue pH” are often used. Work in our laboratory has dealt more with relations covered by these terms than with the actual conditions of tissue swelling or edema. However, it is felt that a discussion of some basic principles related to the normal acid-base regulation of brain tissue will be helpful when considering the even more intricate problems of a tissue with disturbed water and electrolyte metabolism.


Carbonic Anhydrase Tissue Water Bicarbonate Concentration Carbonic Anhydrase Inhibition Tissue Tension 
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Copyright information

© Springer-Verlag New York Inc. 1967

Authors and Affiliations

  • B. K. Siesjö
  • J. Brzeziński
  • Å. Kjällquist
  • U. Pontén

There are no affiliations available

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