Abstract
Recent work in a number of laboratories has shown that the passage of metabolites into and out of the brain occurs through a mechanism that differs from the mechanism governing the passage of foreign substances, including most drugs and dyes. It seems that diffusion, which plays a major role in the passage of foreign substances, has only an insignificant role in the passage of metabolites, which enter, and perhaps leave, the brain through mediated transport. It has been emphasized that these transport mechanisms, which determine the permeability properties of the brain towards metabolites, cannot be localized in a single membrane or in a single anatomical structure, but are most likely present in all membranes, with some differences existing between the properties of these membranes (Lajtha). Therefore, metabolite transport in the nervous system is considered a part of the brain barrier system. Although quantitative differences undoubtedly exist between brain and other organs, our knowledge is not sufficient to permit us to decide whether transport mechanisms present in brain are peculiar to this organ and are not present in other organs.
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References
Abadom, P. N. and P. G. Scholefield: Amino acid transport in brain cortex slices. II. Competition between amino acids, Can. J. Biochem. Physiol., 40, 1591–1602 (1962).
Blasberg, R. G. and A. Lajtha: Substrate specificity of steady state amino acid transport in mouse brain slices, Arch. Biochem. Biophys. 112. 361–377 (1965a).
Blasberg, R. G. and A. Lajtha: Heterogeneity of the mediated transport systems of amino acid uptake in brain, Brain Research 1, 86–104 (1965b).
Christensen, H. N.: Biological Transport, W. A. Benjamin, Inc.: New York (1962).
Christensen, H. N.: A transport system serving for mono-and diamino acids, Proc. Natl. Acad. Sci. U. S., 51, 337–344 (1964).
Heinz, E. and P. M. Walsh: Exchange diffusion, transport, and intracellular level of amino acids in Ehrlich carcinoma cells, J. Biol. Chem., 233, 1488–1493 (1958).
Lajtha, A.: The brain barrier system, in: Neurochemistry (ed. by K. A. C. Elliott, I. H. Page, and J. H. Quastel), Springfield: Charles C. Thomas; pp. 399–430 (1962).
Lajtha, A., and J. Toth: The brain barrier system. II. Uptake and transport of amino acids by the brain, J. Neurochem., 8, 216–225 (1961).
Levi, G., R. G. Blasberg and A. Lajtha: Substrate specificity of amino acid exit from mouse brain slices (in preparation).
Neame, K. D.: Phenylalanine as inhibitor of transport of amino acids in brain, Nature, 192, 173–174 (1961).
Neame, K. D.: Effect of amino acids on uptake of L-histidine by rat brain slices, J. Neurochem., U, 67–76 (1964).
Oxender, D. L. and H. N. Christensen: Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell, J. Biol. Chem., 238, 3686–3699 (1963).
Rosenberg, L. E., S. J. Downing and S. Segal: Competitive inhibition of dibasic amino acid transport in rat kidney, Ibid., 237, 2265–2270 (1962).
Wilson, T. H.: Intestinal Absorption, Philadelphia: W. B. Saunders Co. (1962).
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Lajtha, A., Levi, G., Blasberg, R. (1967). Specificity of Cerebral Amino Acid Transport. In: Klatzo, I., Seitelberger, F. (eds) Brain Edema. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7545-3_27
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DOI: https://doi.org/10.1007/978-3-7091-7545-3_27
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7547-7
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