Brain Edema pp 360-366 | Cite as

Model of the Blood-Brain Barrier System

  • T. Broman
  • O. Steinwall
Conference paper


The term blood-brain barrier (BBB) denotes the fact that in the brain there is an extraordinary impediment to blood-tissue passage of most plasma solutes, in comparison with such passage in other organs. We know today that this simple definition covers a very intricate biological mechanism and the rapidly increasing literature has provided a very large amount of observations and also many controversial hypotheses. The old idea of a structurally and functionally unitary barrier is now generally abandoned, but the BBB concept is still useful as a heading for the various factors that contribute to the restricted permeation from blood to brain. Among these factors biological transport mechanisms have attracted particular interest in the last years. In the following we will sketch a necessarily much simplified picture of the interrelationship between such transport and certain blood-brain barrier phenomena. (For extensive reviews of recent trends in this field, see, e.g., Tschirgi, 1960; Lajtha, 1962; Davson, 1963; Dobbing, 1963; Edström, 1964; Broman & Steinwall, in press.)


Brain Edema Barrier Effect Sodium Fluorescein Plasma Solute Specific Transfer 
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  1. Becker, H. and G. Quadbeck: Tierexperimentelle Untersuchungen über die Funktionsweise der Blut-Hirnschranke, Z. Naturforsch. Vol. 7, 493–497 (1952).Google Scholar
  2. Brodie, B. B., H. Kurz and L. S. Schanker: The importance of dis-sociation constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid, J. Pharmacol, exp. Ther., 130, 20–25 (1960).Google Scholar
  3. Broman, T.: Supravital analysis of disorders in the cerebral vas-cular permeability in man, Acta med. scand., 118, 79–83 (1944).CrossRefGoogle Scholar
  4. Broman, T., S. I. Branemark, B. Johansson and O. Steinwall: Intravital and postmortem studies on air embolism damage of the blood- brain barrier tested with trypan blue, Acta Neurol. Scand. (in press) (1965).Google Scholar
  5. Broman, T., O. Grontoft and O. Steinwall: Comparative intravital and post-mortem studies on chemically induced blood-brain barrier damage tested with trypan blue, Ibid.Google Scholar
  6. Broman, T., and O. Steinwall: Blood-brain barrier, in: Neuropathology, (ed. by J. Minckler), New York: McGraw-Hill, Ch. 33 (in press).Google Scholar
  7. Crone, C.: Om diffusionen af nogle organiske non-elektrolyter fra blod til hjernevaev, Ejnar Munksgaard (1961).Google Scholar
  8. Davson, H.: The cerebrospinal fluid, Ergebn. Physiol., 52, 20–73 (1963).Google Scholar
  9. Dobbing, J.: The blood-brain barrier: Some recent developments, Guy Hosp. Rep., 112, 267–286 (1963).Google Scholar
  10. Edström, R. F. S.: An explanation of the blood-brain barrier phenomenon, Acta. Biochem 33, 403–416 (1958).Google Scholar
  11. Edström, R.: Recent developments of the blood-brain barrier concept, Int. Rev. Neurobiol 153–190 (1964).Google Scholar
  12. Flodmark, S. and O. Steinwall: Differentiated Effects on Certain Blood-Brain Barrier Phenomena and on the EEG Produced by Means of Intracarotidally Applied Mercuric Dichloride, Acta physiol. scand., 57, 446–453 (1963)PubMedCrossRefGoogle Scholar
  13. Hager, H.: Elekronenmikroskopische Untersuchungen über die Feinstruktur der Blutgefässe und perivasculären Räume im Säugetier gehirn, Acta Neuropath., 1, 9–33 (1961).PubMedCrossRefGoogle Scholar
  14. Klatzo, I., J. Miquel, P. J. Ferris, J. D. Prokop and D. E. Smith: Observations on the passage of the fluorescein labeled serum proteins (FLSP) from the cerebrospinal fluid, J. Neuropath. Exp. Neurol., 23, 18 (1964).PubMedCrossRefGoogle Scholar
  15. Krogh, A.: The active and passive exchange of inorganic ions through the surfaces of living cells and through living membranes generally, Proc. roy. Soc. B, 133, 140–200 (1946).Google Scholar
  16. Rodriguez, L. O.: Experiments on the histologic locus of the hematoencephalic barrier, J. comp. Neurol., 102, 27–39 (1955).PubMedCrossRefGoogle Scholar
  17. Steinwall, O.: An improved technique for testing the effect of contrast media and other substances on the blood-brain barrier, Acta Radiol., 49, 281–284 (1958).PubMedCrossRefGoogle Scholar
  18. Steinwall, O.: Transport mechanisms in certain blood-brain barrier phenomena — a hypothesis, Acta Psychiat. Neurol. Scand., 36, suppl. 150, 314–318 (1961).Google Scholar
  19. Steinwall, O., and I. Klatzo: Double tracer methods in studies on blood-brain barrier dysfunction and brain edema, Acta Neurol. Scand., 41, suppl. 13, 591–595 (1965).Google Scholar
  20. Steinwall, O., and I. Klatzo: Selective vulnerability of the blood-brain barrier in chemically induced lesions, J. Neuropath. Exp. Neurol., 25, 542–559 (1966).PubMedCrossRefGoogle Scholar
  21. Tower, D. B.: Molecular transport across neural membranes, in: Properties of membranes and diseases of the nervous system, New York: Springer, 1–40 (1962).Google Scholar
  22. Tschirgi, R. D.: Chemical environment of the central nervous system, in: Handbook of Physiology, vol. III, 1865–1890 (ed. by Field, Magoun, and Hall), Baltimore: Amer. Physiol. Soc. (1960).Google Scholar

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© Springer-Verlag New York Inc. 1967

Authors and Affiliations

  • T. Broman
  • O. Steinwall

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