Brain Edema pp 303-332 | Cite as

Distribution of Cerebral Fluids and Electrolytes In Vivo and In Vitro

  • Donald B. Tower


Older concepts of brain edema based on gross changes of brain volume and fluid content (Elliott & Jasper; Schaltenbrand & Bailey; Weed, et al.), have been modified by recognition that some forms of edema affect cerebral cortex primarily while others involve subcortical white matter rather selectively. Recognition of swelling of cerebral cortex may be credited to Elliott, and the phenomenon has been subsequently investigated in detail by Leaf; by Pappius, et al. (1956, 1958, 1962); and by Varon and McIlwain among others. Selective edema of white matter was demonstrated in the classic study by Stewart-Wallace and has more recently been studied experimentally by Aleu, et al., and by Pappius and Gulati, among others. Much of the current morphological and biochemical work in these fields is represented by contributions to this conference and need not be reviewed here.


Cerebral Cortex Circulatory Arrest Cortical Slice Fluid Space Indicator Solute 
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© Springer-Verlag New York Inc. 1967

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  • Donald B. Tower

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