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Brain Edema pp 303-332 | Cite as

Distribution of Cerebral Fluids and Electrolytes In Vivo and In Vitro

  • Donald B. Tower

Abstract

Older concepts of brain edema based on gross changes of brain volume and fluid content (Elliott & Jasper; Schaltenbrand & Bailey; Weed, et al.), have been modified by recognition that some forms of edema affect cerebral cortex primarily while others involve subcortical white matter rather selectively. Recognition of swelling of cerebral cortex may be credited to Elliott, and the phenomenon has been subsequently investigated in detail by Leaf; by Pappius, et al. (1956, 1958, 1962); and by Varon and McIlwain among others. Selective edema of white matter was demonstrated in the classic study by Stewart-Wallace and has more recently been studied experimentally by Aleu, et al., and by Pappius and Gulati, among others. Much of the current morphological and biochemical work in these fields is represented by contributions to this conference and need not be reviewed here.

Keywords

Cerebral Cortex Circulatory Arrest Cortical Slice Fluid Space Indicator Solute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ames, A., J. B. Isom and F. B. Nesbett: Effects of osmotic changes on water and electrolytes in nervous tissue, J. Physiol. (London), 177, 246–262 (1965).Google Scholar
  2. Aleu, F. P., R. Katzman and R. D. Terry: Structure and electrolyte analyses of cerebral edema induced by alkyl tin intoxication, J. Neuropath. Exp. Neurol., 22, 403–413 (1963).PubMedCrossRefGoogle Scholar
  3. Bahr, G. F., G. Bloom and U. Friberg: Volume changes of tissue in physiological fluids during fixation in osmium tetroxide or for-maldehyde and during subsequent treatment, Exp. Cell Res., 12, 342–355 (1957).CrossRefGoogle Scholar
  4. Aleu, F. P., R. Katzman, R. D., and E. Johannisson: Further studies on fixation with osmium tetroxide, Histochemie, J., 113–118 (1958).Google Scholar
  5. Berl, S.: Compartmentation of glutamic acid metabolism in developing cerebral cortex, J. Biol. Chem., 240, 2047–2054 (1965).PubMedGoogle Scholar
  6. Berl, S. and D. P. Purpura: Postnatal changes in amino acid content of kitten cerebral cortex, J. Neurochem., 10, 237–240 (1963).PubMedCrossRefGoogle Scholar
  7. Birks, R. I.: The effects of a cardiac glycoside on subcellular structures within nerve cells and their processes in sympathetic ganglia and skeletal muscle, Canad. J. Biochem. Physiol., 40, 303–315 (1962).PubMedCrossRefGoogle Scholar
  8. Brizee, K. R. and L. A. Jacobs: Postnatal changes in volumetric and density relationships of neurons in cerebral cortex of cat, Acta Anat., 38, 291–303 (1959).CrossRefGoogle Scholar
  9. Brizee, K. R. and L. A. Jacobs: The glia/neuron index in the submolecular layers of motor cortex in the cat, Anat. Record, 134, 97–105 (1959).Google Scholar
  10. Bourke, R. S., E. S. Greenberg and D. B. Tower: Variation of cerebral cortex fluid spaces in vivo as a function of species brain size, Am. J. Physiol., 208, 682–692 (1965).PubMedGoogle Scholar
  11. Bourke, R. S., E. S. Greenberg and D. B. Tower: Fluid compartmentation and electrolytes of cat cerebral cortex in vitro. I. Swelling and solute distribution in mature cerebral cortex. J. Neurochem., 13, 1071–1097 (1966).PubMedCrossRefGoogle Scholar
  12. Brightman, M. W.: The distribution within brain of ferritin injected into cerebrospinal fluid compartments. I. Ependymal distribution, J. Cell Biol., 26, 99–123 (1965).PubMedCrossRefGoogle Scholar
  13. Cotlove, E.: Mechanism and extent of distribution of inulin and sucrose in chloride space of tissues, Am. J. Physiol., 176, 364–410 (1954).Google Scholar
  14. Davson, H. and E. Spaziani: The blood-brain barrier and the extra-cellular space of brain, J. Physiol. (London), 149, 135–143 (1959).Google Scholar
  15. Elliott, K. A. C.: Swelling of brain slices and the permeability of brain cells to glucose, Proc. Soc. Exp. Biol. Med., 63, 234236 (1946).Google Scholar
  16. Elliott, K. A. C. and H. H. Jasper: Measurement of experimentally induced brain swelling and shrinkage, Am. J. Physiol., 157, 122–129 (1949).PubMedGoogle Scholar
  17. Farquhar, M. G. and J. F. Hartmann: Neuroglial structure and relationships as revealed by electron microscopy, J. Neuropath. Exp. Neurol, 16, 18–39 (1957).PubMedCrossRefGoogle Scholar
  18. Flexner, L. B. and J. B. Flexner: Biochemical and physiological differentiation during morphogenesis. IX. The extracellular and intracellular phases of the liver and cerebral cortex of the fetal guinea pig as estimated from distribution of chloride and radio-sodium, J. Cell. Comp. Physiol., 34, 115–127 (1949).CrossRefGoogle Scholar
  19. Freygang, W. H. and W. M. Landau: Some relations between resistivity and electrical activity in the cerebral cortex of the cat, J. Cell Comp. Physiol., 45, 377–392 (1955).CrossRefGoogle Scholar
  20. Friede, R.: Der quantitative Anteil der Glia an der Cortexentwicklung, Acta Anat., 20, 290–296 (1954).PubMedCrossRefGoogle Scholar
  21. Gerschenfeld, H. M., F.Wald, J. A. Zadunaisky and E. D. P. De Robertis: Funtion of astroglia in the water-ion metabolism of the central nervous system, Neurology, 9, 412–425 (1959).PubMedGoogle Scholar
  22. Gibson, I. M. and H. Mcllwain: Continuous recording of changes in membrane potential in mammalian cerebral tissues in vitro; recovery after depolarization by added substances, J. Physiol. (London), 176, 261–263 (1965).Google Scholar
  23. Hawkins, A, and J. Olszewski: Glia/nerve index for cortex of the whale, Science, 126, 76–77 (1957).PubMedCrossRefGoogle Scholar
  24. Horstmann, E. and H. Meves: Die Feinstruktur des molecularen Rindengraues und ihre physiologische Bedeutung, Z. Zellforsch u. mikroskop. Anat. 49, 569–604 (1959).Google Scholar
  25. Katzman, R.: Electrolyte distribution in mammalian central nervous system, Neurology, U, 27–36 (1961).Google Scholar
  26. Keesey, J. C., H. Wallgren and H. Mcllwain: The sodium, potassium and chloride of cerebral tissues: maintenance, change on stimulation and subsequent recovery, Biochem. J., 95, 289–300 (1965).PubMedGoogle Scholar
  27. Klatzo, I., A. Piraux and E. J. Laskowski: The relationship between edema, blood-brain barrier and tissue elements in a local brain injury, J. Neuropath. Exp. Neurol., 17, 548–564 (1958).PubMedCrossRefGoogle Scholar
  28. Koch, A., J. B. Ranck and B. L. Newman: Ionic content of the neuroglia, Expleurol., 6, 186–200 (1962).Google Scholar
  29. Koechlin, B. A.: On the chemical composition of the axoplasm of squid giant nerve fibers with particular reference to its ion pattern, J:Biophys. Biochem.Cytol., 511–529 (1955).Google Scholar
  30. Kuffler, S. W. and D. D. Potter: Glia in the leech central nervous system: physiological properties and neuron-glia relationship, J. Neurophysiol., 27, 290–320 (1964).PubMedGoogle Scholar
  31. Leaf, A.: On the mechanism of fluid exchange of tissues in vitro, Biochem. J., 62, 241–248 (1956).PubMedGoogle Scholar
  32. Nichols, J. G. and S. W. Kuffler: Extracellular space as a pathway for exchange between blood and neurons in the central nervous system of the leech: ionic composition of glial cells and neurons, J. Neurophysiol., 27, 645–671 (1964).Google Scholar
  33. Noback, C. R., E. M. Housepian and D. P. Purpura: Development of cat neocortex, Anat. Ree., 139, 260 (1961).Google Scholar
  34. Noback, C. R., E. M. Housepian and D. P. Purpura: Postnatal ontogenesis of neurons in cat neocortex, J. Comp. Neurol., 117, 291–307 (1961).PubMedCrossRefGoogle Scholar
  35. Pappius, H. M. and K. A. C. Elliott: Water distribution in incubated slices of brain and other tissues, Canad. J. Biochem. Physiol., 34, 1007–1022 (1956).PubMedCrossRefGoogle Scholar
  36. Pappius, H. M. and D. R. Gulati: Water and electrolyte content of cerebral tissues in experimentally induced edema, Acta Neuropath., 2, 451–460 (1963).CrossRefGoogle Scholar
  37. Pappius, H. M., I. Klatzo and K. A. C. Elliott: Further studies on swelling of brain slices, Canad. J. Biochem. Physiol., 40, 886–898 (1962).CrossRefGoogle Scholar
  38. Pappius, H. M., M. Rosenfeld, D. M. Johnson and K. A. C. Elliott: Effects of sodium-free media upon the metabolism and the potassium and water contents of brain slices, Canad. J. Biochem. Physiol., 36, 217–226 (1958).PubMedCrossRefGoogle Scholar
  39. Pascal, B.: [Cited by C. Stern: Thoughts on research, Science, 148, 772–773 (1965).]Google Scholar
  40. Phelps, C. F.: The physical properties of inulin solutions, Biochem. J, 95, 41–47 (1965).PubMedGoogle Scholar
  41. Rail, D. P., W. W. Oppelt and C. S. Patlack: Extracellular space of brain as determined by diffusion of inulin from the ventricular system, Life Sci., 1: 2, 42–48 (1962).Google Scholar
  42. Reed, D. J. and D. M. Woodbury: Kinetics of movement of iodide, sucrose, inulin and radio-iodinated albumin in the central nervous system and cerebrospinal fluid of the rat, J. Physiol. (London), 169, 816–850 (1963).Google Scholar
  43. Pappius, H. M., and L. Holtzer: Brain edema, electrolytes and extracellular space, Arch. Neurol., 10, 604–614 (1964).Google Scholar
  44. Schaltenbrand, G. and P. Bailey: Die perivaskuläre Piagliamembran des Gehirns, J. f. Psychol, u. Neurol., 35, 199–278 (1928).Google Scholar
  45. Schultz, R. L., E. A. Maynard and D. C. Pease: Electron microscopy of neurons and neuroglia of cerebral cortex and corpus callosum, Am. J. Path., 100, 369–408 (1957).Google Scholar
  46. Schariff, G. A.: Cell counts in the primate cerebral cortex, J. Comp. Neurol., 98, 381–400 (1953).CrossRefGoogle Scholar
  47. Siekevitz, P.: On the meaning of intracellular structure for metabolic regulation, in: Ciba Symposium on Regulation of Cell Metabolism (ed. by G. E. W. Wolstenholme and C. M. O’Connor) Boston: Little, Brown, pp. 17–45 (1959).Google Scholar
  48. Stern, J. R., L. V. Eggleston, R. Hems and H. A. Krebs: Accumulation of glutamic acid in isolated brain tissue, Biochem. J. 44, 410–418 (1949).Google Scholar
  49. Stewart-Wallace, A. M.: Biochemical study of cerebral tissue, and changes in cerebral edema, Brain, 62, 426–438 (1939).CrossRefGoogle Scholar
  50. Streicher, E.: The thiocyanate space of rat brain in experimental cerebral edema, J. Neuropath. Exp. Neurol., 21, 437–441 (1962).PubMedCrossRefGoogle Scholar
  51. Thomas, J. and H. Mcllwain: Chloride content and metabolism of cerebral tissues in fluids low in chlorides, J. Neurochem., J., 1–7 (1956).Google Scholar
  52. Tobias, J. M.: A chemically specified molecular mechanism underlying excitation in nerve: a hypothesis, Nature (London), 203, 13–17 (1964).CrossRefGoogle Scholar
  53. Tooze, J.: Measurement of some cellular changes during fixation of amphibian erythrocytes with osmium tetroxide, J. Cell Biol., 22, 551–563 (1964).PubMedCrossRefGoogle Scholar
  54. Torack, R. M., R. D. Terry and H. M. Zimmerman: Fine structure of cerebral fluid accumulation. II. Swelling produced by triethyltin poisoning compared with that in human brain, Am. J. Path., 36, 273–287 (1960).PubMedGoogle Scholar
  55. Tower, D. B.: Structural and functional organization of mammalian cerebral cortex: The correlation of neurone density with brain size. Cortical neurone density in the fin whale (Balaenoptera physalus L.) with a note on the cortical neurone density in the Indian elephant, J. Comp. Neurol., 101, 19–52 (1954).PubMedCrossRefGoogle Scholar
  56. Tower, D. B.: The effects of 2-deoxy-D-glucose on metabolism of slices of cerebral cortex incubated in vitro, J. Neurochem., 3, 185–205 (1958).PubMedCrossRefGoogle Scholar
  57. Tower, D. B.: Problems associated with studies of electrolyte metabolism in normal and epileptogenic cerebral cortex, Epilepsia, 6, 183–197 (1965).PubMedCrossRefGoogle Scholar
  58. Tower, D. B. and R. S. Bourke: Fluid compartmentation and electrolytes of cat cerebral cortex in vitro.III. Ontogenetic and comparative aspects, J. Neurochem., 13, 1119–1137 (1966).PubMedCrossRefGoogle Scholar
  59. Tower, D. B. and K. A. C. Elliott: Activity of acetylcholine system in cere¬bral cortex of various unanesthetized mammals, Am. J. Physiol., 168, 747–759 (1952).PubMedGoogle Scholar
  60. Van Harreveld, A., J. Crowell and S. K. Malhotra: A study of extra-cellular space in central nervous tissue by freeze-substitution. J. Cell Biol., 25, 117–137 (1965).CrossRefGoogle Scholar
  61. Tower, D. B. and J. P. Schade: On distribution and movements of water and electrolytes in cerebral cortex, in: Structure and Function of the Cerebral Cortex (ed. by D. B. Tower and J. P. Schadfe), Amsterdam: Elsevier, pp. 239–254 (1960).Google Scholar
  62. Varon, S. and H. Mcllwain: Fluid content and compartments in iso¬lated cerebral tissues, J. Neurochem., 8, 262–275 (1961).PubMedCrossRefGoogle Scholar
  63. Vernadakis, A. and D. M. Woodbury: Electrolyte and amino acid changes in rat brain during maturation, Am. J. Physiol., 203, 748–752 (1962).PubMedGoogle Scholar
  64. Voeller, K., G. D. Pappas, and D. P. Purpura: Electron microscope study of development of cat superficial neocortex, Exp. Neurol. 7, 107–130 (1963).Google Scholar
  65. Wanko, T. and D. B. Tower: Combined morphological and biochemical studies of incubated slices of cerebral cortex, in: Morphological and Biochemical Correlates of Neural Activity (ed. by M. M. Cohen and R. S. Snider), New York: Hoeber-Harper, pp. 75–97 (1964)Google Scholar
  66. Weed,L. H. and W. Hughson: Intracranial venous pressure and cerebrospinal fluid pressure as affected by the intravenous injection of solutions of various concentrations, Am. J. Physiol., 58, 101–130 (1921).Google Scholar
  67. Weed,L. H. and P. S. McKibben: Experimental alteration of brain bulk, Am. J. Physiol., 48, 531–558 (1919).Google Scholar
  68. Welty, J. D., W. O. Reed and E. H. Shaw: Isolation of 2-hydroxy- ethane-sulfonic acid (isethionic acid) from dog heart, J. Biol. Chem., 237, 1160–1161 (1962).PubMedGoogle Scholar

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© Springer-Verlag New York Inc. 1967

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  • Donald B. Tower

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