Brain Edema pp 207-222 | Cite as

Lead Encephalopathy in Suckling Rats

An Electron Microscopic Study
  • P. Lampert
  • F. Garro
  • A. Pentschew


The morphology of lead encephalopathy in infants and children is well documented by light microscopy (Blackman, 1937; Pentschew, 1958; Smith, et al., 1960; Popoff, et al., 1963; Pentschew, 1965). Vascular damage and serous exudation followed by endothelial, microglial and astrocytic proliferation are prominent features. The cerebellum is most frequently affected. Similar morphological alterations develop in the brains of suckling rats when their mothers are fed a diet containing lead carbonate (Pentschew, et al., 1966). The purpose of this paper is to present some electron microscopic observations on this lead encephalopathy in suckling rats together with an account on the vascular permeability to Trypan Blue and Thorotrast, an electron dense tracer.


White Matter Trypan Blue Microglial Cell Intercellular Space Myelin Sheath 
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  1. Ashton, N. and J. G. Cunha-Vaz: Effect of histamine on the permeability of the ocular vessels, Arch. Ophthal., 73, 211–223 (1965).Google Scholar
  2. Blackman, S. S.: The lesions of lead encephalitis in children. Bull. Johns Hopkins Hosp., 61, 1–62 (1937).Google Scholar
  3. Casley-Smith, J. R.: Endothelial permeability, II, The passage of particles through the lymphatic endothelium of normal and injured ears, British J. Exp. Path., 46, 35–49 (1965).Google Scholar
  4. Dalton, A. J.: A chromeosmium fixative for electron microscopy, AnaL. Rec., 121, 281 (1955).Google Scholar
  5. Herzog, I., W. A. Levy and L. C. Scheinberg: Biochemical and morphologic studies of cerebral edema associated with intracerebral tumors in rabbits, J. Neuropath. & Exp. Neurol., 24, 224–255 (1965).Google Scholar
  6. Hirano, A., H. M. Zimmerman and S. Levine: The fine structure of cerebral fluid accumulation, III: Extracellular spread of cryptococcal polysaccharides in the acute stage, Am. J. Path.. 45, 1–19 (1964).PubMedGoogle Scholar
  7. Klatzo, I. and J. Miquel: Observations on pinocytosis in nervous tissue, J. Neuropath. & Exp. Neurol., 19, 475–487 (1960).CrossRefGoogle Scholar
  8. Lampert, P. and S. Carpenter: Electron microscopic studies on the vascular permeability and the mechanism of demyelination in experimental allergic encephalomyelitis, J. Neuropath. & Exp. Neurol.. 24. 11–24 (1965).CrossRefGoogle Scholar
  9. Lampert, P. and M. Cressman: Axonal regeneration in the dorsal columns of the spinal cord of adult rats: an electron microscopic study, Lab. Invest.. 13. 825–839 (1964).Google Scholar
  10. Levine, S., H. M. Zimmerman, E.J. Wenk and N. K. Gonatas: Experimental leukoencephalopathies due to implantation of foreign substances, Am. J. Path.. 42, 97–117 (1963).PubMedGoogle Scholar
  11. Luft, J. M.: Improvement in epoxy resin embedding methods, J. Biophys. Biochem. Cytol., 9, 409–414 (1961).PubMedCrossRefGoogle Scholar
  12. Majno, G. and G. E. Palade: Studies on inflammation, I, The effect of histamine and serotonin on vascular permeability. An electron microscopic study, J. Biophys. Biochem. Cytol., 11, 571–605 (1961).PubMedCrossRefGoogle Scholar
  13. Movat, H. Z. and N. V. Fernando: Acute inflammation. The earliest fine structural changes at the blood-tissue barrier, Lab. Invest.. 12, 895–910 (1963a).Google Scholar
  14. Movat, H. Z. and: Allergic inflammation, I: The earliest fine structural changes at the blood-tissue barrier during antigen- antibody interaction. Am. J. Path., 42. 41–50 (1963b).PubMedGoogle Scholar
  15. Palay, S. L., S. M. McGee Russell, S. Gordon and M. A. Grillo: Fixation of neural tissue for electron microscopy by perfusion with solutions of osmium tetroxide, J. Cell Biol., 12. 385–419 (1962).PubMedCrossRefGoogle Scholar
  16. Pentschew, A.: Intoxikationen; in Handbuch der speziellen pathologischen Anatomie und Histologie (ed. by W. Scholz), Vol. XIII, 2, 1929–1971 (1958).Google Scholar
  17. Pentschew, A.: Morphology and morphogenesis of lead encephalopathy. Acta Neuropathology, 5, 133–160 (1965).CrossRefGoogle Scholar
  18. Pentschew, A., F. Garro and P. Schweda: Systemized dysoric encephalopathy in the suckling rat produced by lead, Proceedings Vth Intern. Congress Neuropath., Excerpta Medica, 730–733 (1966).Google Scholar
  19. Popoff, N., S. Weinberg and I. Feigin: Pathologic observations in lead encephalopathy with special reference to the vascular changes, Neurology, 13, 101–102 (1963).PubMedGoogle Scholar
  20. Rowley, D. S.: Mast cell damage and vascular injury in the rat. An electron microscopic study of a reaction produced by Thorotrast, British J. Exp. Path., 44, 284–290 (1963).Google Scholar
  21. Smith, J. F., R. L. Laurin, J. B. Nichols and A. Ashbury: Studies in cerebral edema and cerebral swelling. The changes in lead encephalopathy in children compared with those in alkyl tin poisoning in animals, Brain, 83, 411–429 (1960).CrossRefGoogle Scholar
  22. Struck, G. and W. Umbach: Vergleichende elektronenoptische Untersuchungen an der menschlichen Hirnrinde vor und nach Odemtherapie, Virtfu. 317–327 (1964).Google Scholar
  23. Tani, E. and J. P. Evans: Electron microscopic studies of cerebral swelling. I. Studies on the permeability of brain capillaries, using Ferritin molecules as tracers, Acta Neuropath., 4, 507–526 (1965).CrossRefGoogle Scholar

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© Springer-Verlag New York Inc. 1967

Authors and Affiliations

  • P. Lampert
  • F. Garro
  • A. Pentschew

There are no affiliations available

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