Advertisement

Brain Edema pp 187-194 | Cite as

Chemical Aspects of Edematous Brain

  • J. N. Cumings
Conference paper

Abstract

Some biochemical aspects of human cerebral edema associated with tumor, abscess and vascular disorders have already been described (Cumings, 1961, 1962). These examinations demonstrated that the soluble cerebral proteins, extracted from the brain tissue by 0.3 M sucrose, contained numerous proteins but only included albumin from the area of the edema, which was most frequently in the white matter. The proteins present were at that time visualized following starch gel electrophoresis, while the patterns of a number of different enzymes associated with the various protein fractions were also studied. There were some slight changes in enzyme pattern between the normal and the edematous areas, more especially in the white matter and it was then concluded that when cerebral edema occurred in the white matter in association with either a tumor or an abscess, much of the fluid could be extracellular. Nevertheless, when the edema was associated with a cerebrovascular lesion the findings were equally compatible with some or possibly most of the edema fluid being within the myelin sheath and the myelin cell.

Keywords

White Matter Edematous Brain Myelin Sheath Chemical Aspect Cerebral Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cumings, J. N.: Soluble cerebral proteins in normal and oedematous brain, J. Clin. Path.. 14. 289–294 (1961).PubMedCrossRefGoogle Scholar
  2. Cumings, J. N.: Water soluble proteins and enzymes in normal and in oedematous brain tissue, Proceedings of IV. International Congress of Neuropathology, München, Thema I, Vol. I, (1961), (ed. by H. Jacob), Stuttgart: Georg Thieme Verlag, 157–161 (1962).Google Scholar
  3. Elliott, K. A. C. and H. Jasper: Measurement of experimentally induced brain swelling and shrinkage, Amer. J. Physiol., 157, 122–129 (1949).Google Scholar
  4. Herschkowitz, N., B. B. MacGillivray and J. N. Cumings: Biochemical and electrophysiological studies in experimental cerebral oedema, Brain, 88, 557–584 (1965).PubMedCrossRefGoogle Scholar
  5. Kaisbeck, J. E. and J. N. Cumings: Experimental edema in the rat and cat brain, J. Neuropath, exp. Neurol., 22, 237–247 (1963).CrossRefGoogle Scholar
  6. Monseu, G. and J. N. Cumings: Polyacrylamide disc electrophoresis of the proteins of cerebrospinal fluid and brain, J. Neurol. Neurosurg. Psychiat., 28, 56–60 (1965).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1967

Authors and Affiliations

  • J. N. Cumings

There are no affiliations available

Personalised recommendations