Asthma pp 71-79 | Cite as

Similarities of exogenous and endogenous allergens; IgE-autoreactivity in atopic patients

  • Rudolf Valenta
  • M. Duchêne
  • K. Pettenburger
  • Ch. Sillaber
  • P. Valent
  • D. Kraft
  • O. Scheiner
Conference paper


Using serum-IgE from a birch pollen allergic patient we isolated a pollen cDNA encoding for birch profilin. Profilins are ubiquitous cytoskeletal proteins which also participate in the phosphoinositol pathway and in signal transduction. Despite the low degree of sequence homology between plant and mammalian profilins we could demonstrate a distinct IgE-autoreactivity against human profilin in sensitized patients. This phenomenon lead us to investigate the role of autoimmune mechanisms in the maintenance and aggravation of allergic diseases. Endogenous booster mechanisms could be responsible for the elevated anti-birch profilin IgE-titers in sensitized individuals. In addition we demonstrated IgE autoreactivity against a number of human proteins in atopic patients, most pronounced in patients suffering from atopic dermatitis and intrinsic asthma bronchiale suggesting a relevant role of IgE-autoimmunity in the pathogenesis of these diseases.


Histamine Release Pollen Season Acrosomal Reaction Birch Pollen Atopic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Ähnlichkeiten zwischen exogenen und endogenen Allergenen; IgE-Autoreaktivität bei atopischen Patienten


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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • Rudolf Valenta
    • 1
  • M. Duchêne
    • 1
  • K. Pettenburger
    • 1
  • Ch. Sillaber
    • 2
  • P. Valent
    • 2
  • D. Kraft
    • 1
  • O. Scheiner
    • 1
  1. 1.Institute of General and Experimental Pathology, AKHUniversity of ViennaAustria
  2. 2.Department of Internal Medicine, AKHUniversity of ViennaAustria

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