Asthma pp 12-22 | Cite as

IgE mediated antigen presentation

  • G. C. Mudde
  • L. C. Santamaria
  • F. C. v. Reijsen
  • R. Beekkha
  • C. A. F. M. Bruijnzeel-Koomen
Conference paper


Immune responses depend on the efficiency of antigen capture by antigen presenting cells (APC’s). Three mechanisms of antigen capture are generally accepted: Phagocytosis, pinocytosis and specific surface immunoglobulin (B cells). Recent observations by several groups point in the direction of a fourth mechanism for antigen capture: IgE bound to FcεR’s on APC’s may permit binding of antigens to APC’s prior to their processing and presentation. The unique characteristics of IgE serological responses, together with the distribution of (high and low) affinity IgE receptors (FcεRI resp. CD23) on APC’s, provides clues to this novel function for IgE. The concept of IgE involvement in antigen capture, both in vivo and in vitro, is discussed in relation to Langerhans’ cells, B cells, and follicular dendritic cells.


Atopic Dermatitis High Affinity Receptor Follicular Dendritic Cell Antigen Uptake Antigen Capture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

IgE — mediierte Antigenpräsentation


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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • G. C. Mudde
    • 4
  • L. C. Santamaria
    • 2
  • F. C. v. Reijsen
    • 3
  • R. Beekkha
    • 1
  • C. A. F. M. Bruijnzeel-Koomen
    • 3
  1. 1.Department of Dermatology, ID2Sandoz Forschungs Institut GmbHAustria
  2. 2.Swiss Institute of Allergy and Asthma Research (SIAF)DavosSwitzerland
  3. 3.Department of DermatologyDermato-Allergology Unit University HospitalUtrechtThe Netherlands
  4. 4.Department of Dermatology, ID2Sandoz Forschungs Institut GmBHViennaAustria

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