Development of bambuterol; a long acting, orally active beta-agonist prodrug

  • Leif-Ake Svensson
Conference paper


Bambuterol, Bambec®, is a novel, orally active, long-acting bronchodilator with 24 hours duration of action and a lower incidence of adverse advents as compared with other oral bronchodilators [1]. Bambuterol, dimethylcarbamic acid 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester, is a prodrug to the β2-adrenoceptor agonist terbutaline. It was developed by Astra Draco AB, and is currently approved for the treatment of bronchial asthma, chronic bronchitis and other lung diseases, where bronchospasm is a complicating factor.

This paper reviews how bambuterol was developed from terbutaline by use of the prodrug technique.


Hydrolytic Stability Plasma Cholinesterase Lung Uptake Ester Prodrug Pivalic Acid 


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Copyright information

© Springer-Verlag/Wien 1998

Authors and Affiliations

  • Leif-Ake Svensson
    • 1
  1. 1.Department of Medicinal ChemistryAstra Draco ABLundSweden

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