The prognosis of mild cognitive impairment in the elderly

  • H. Wolf
  • M. Grunwald
  • G. M. Ecke
  • D. Zedlick
  • S. Bettin
  • C. Dannenberg
  • J. Dietrich
  • K. Eschrich
  • T. Arendt
  • H.-J. Gertz
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 54)


Purpose: To determine whether or not subtypes of intellectual functioning are suitable to predict further cognitive decline in individuals with mild cognitive impairment. Design: naturalistic longitudinal study (mean interval 2.7 years). Patients: 41 subjects with mild cognitive impairment who attended a memory clinic. Methods: SID AM, CT, SPECT, and ApoE genotype. Results: At follow-up, 8 out of 41 patients (19.5%) with MCI had progressed to dementia, 8 patients (19.5%) had improved to normal levels of cognitive functioning, 25 patients (61%) had remained stable within the MCI group. At baseline the two prognostic groups differed significantly with regard to age, memory functions, orientation, and the degree of atrophy of the left medial temporal lobe on CT scan. Conclusion: The majority of MCI patients in this study remained cognitively stable within the observation period. Patients with older age, poorer test performance on memory tasks and orientation deficits are at higher risk of progressive decline to dementia. CT measures of medial temporal lobe atrophy may be a sensitive parameter of group discrimination.


Single Photon Emission Compute Tomography Mildly Cognitively Impaired Medial Temporal Lobe ApoE Genotype Clinical Dementia Rate 
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Copyright information

© Springer-Verlag/Wien 1998

Authors and Affiliations

  • H. Wolf
    • 1
    • 6
  • M. Grunwald
    • 1
  • G. M. Ecke
    • 1
  • D. Zedlick
    • 1
  • S. Bettin
    • 2
  • C. Dannenberg
    • 2
  • J. Dietrich
    • 3
  • K. Eschrich
    • 4
  • T. Arendt
    • 5
  • H.-J. Gertz
    • 1
  1. 1.Department of PsychiatryUniversity of LeipzigFederal Republic of Germany
  2. 2.Department of Nuclear MedicineUniversity of LeipzigFederal Republic of Germany
  3. 3.Department of RadiologyUniversity of LeipzigFederal Republic of Germany
  4. 4.Department of BiochemistryUniversity of LeipzigFederal Republic of Germany
  5. 5.Paul Flechsig Institute for Brain ResearchUniversity of LeipzigFederal Republic of Germany
  6. 6.Department of PsychiatryUniversity of LeipzigLeipzigFederal Republic of Germany

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