Summary
Experience of the use of Donepezil (Aricept™) in the UK since licencing is discussed. The results of a 30 week double blind parallel group study in the US of Donepezil 5 or 10mg versus placebo show statistically significant improvements in cognitive and clinical global assessments. Beneficial effects were demonstrated in the absence of significant adverse effects on physical or laboratory values. The guidelines for use adopted in the UK are discussed with the emphasis on identifying non-cognitive behaviours, as significant improvements in these have been found and often have more impact on quality of life than cognitive improvements alone.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
EISAI Corp (1996) Data on file. Teaneck N J., U.S.A.
Folstein MF, Folstein SE, McHugh PR (1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198
McKeith, et al (1996) Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy Bodies (DLB): report of the consortium on DLB international workshop. Neurology 47: 1113–1124
Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer’s disease. Am J Psych 141/11: 1356–1364
Wilcock G, Banergee A, Burns A, Chubb A, Jones R, Lawlor B, Rossor M, Sharp D, Wilkinson DG (1997) Setting standards in Alzheimer’s disease management in Primary and Secondary care. Geriatr Med 27 (part 3) [Suppl]
World Health Organisation (1992) The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organization, Geneva
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag/Wien
About this paper
Cite this paper
Wilkinson, D. (1998). Clinical experience with donepezil (Aricept™) in the UK. In: Gertz, HJ., Arendt, T. (eds) Alzheimer’s Disease — From Basic Research to Clinical Applications. Journal of Neural Transmission. Supplementa, vol 54. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7508-8_31
Download citation
DOI: https://doi.org/10.1007/978-3-7091-7508-8_31
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83112-0
Online ISBN: 978-3-7091-7508-8
eBook Packages: Springer Book Archive